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The map label for this gene is nuoH [H]

Identifier: 148824346

GI number: 148824346

Start: 3532396

End: 3533637

Strand: Direct

Name: nuoH [H]

Synonym: TBFG_13173

Alternate gene names: 148824346

Gene position: 3532396-3533637 (Clockwise)

Preceding gene: 148824345

Following gene: 148824347

Centisome position: 79.84

GC content: 61.92

Gene sequence:

>1242_bases
GTGGCGGCCATGACCACGTTCGGCCACGACACCTGGTGGCTGGTGGCGGCCAAAGCGATCGCGGTATTCGTGTTCCTCAT
GCTGACGGTGCTGGTGGCGATCCTGGCCGAACGCAAGCTGCTGGGCCGGATGCAGTTGCGGCCCGGCCCCAACCGGGTTG
GCCCAAAAGGAGCCCTGCAGAGCCTGGCTGACGGCATCAAGCTGGCGCTCAAAGAGAGCATCACACCCGGTGGCATCGAT
CGATTCGTATATTTTGTGGCGCCGATCATTTCGGTGATTCCGGCATTCACCGCTTTCGCGTTCATCCCGTTTGGTCCCGA
GGTGTCGGTGTTTGGCCACCGGACACCGTTGCAGATAACCGACCTTCCCGTCGCCGTGCTGTTCATCCTGGGACTGTCGG
CGATCGGGGTATACGGCATCGTGCTGGGCGGTTGGGCGTCCGGGTCCACCTACCCGCTGCTGGGCGGGGTGCGCTCCACC
GCGCAGGTCATCTCCTACGAGGTCGCGATGGGCCTGTCGTTCGCGACGGTGTTCCTTATGGCCGGCACCATGTCGACGTC
GCAGATCGTGGCCGCACAAGACGGTGTCTGGTATGCCTTCCTGTTGTTGCCGTCATTCGTCATCTATCTCATTTCTATGG
TGGGTGAAACCAACCGGGCGCCGTTCGATTTGCCCGAAGCCGAGGGCGAGCTGGTCGCGGGATTCCACACCGAGTACTCG
TCGTTGAAGTTCGCGATGTTCATGCTCGCCGAGTACGTCAATATGACTACGGTTTCGGCACTGGCCGCGACCCTATTCTT
CGGTGGCTGGCATGCTCCCTGGCCGCTGAACATGTGGGCGAGCGCCAACACCGGCTGGTGGCCACTGATCTGGTTCACCG
CTAAAGTGTGGGGCTTTCTGTTCATCTATTTCTGGCTGCGGGCTACGCTGCCGCGGCTGCGCTACGACCAGTTCATGGCG
CTGGGCTGGAAGTTATTGATCCCCGTCTCGCTGGTGTGGGTGATGGTCGCCGCGATCATCCGCTCACTACGCAACCAGGG
CTACCAGTACTGGACCCCGACTCTGGTGTTTAGCAGCATTGTCGTTGCCGCTGCCATGGTGCTGTTGTTGCGAAAGCCGT
TGAGCGCTCCCGGCGCTCGCGCATCGGCACGGCAACGCGGGGACGAAGGCACCAGCCCTGAACCGGCATTTCCGACACCA
CCGCTGCTAGCCGGTGCAACCAAGGAGAATGCAGGTGGCTAA

Upstream 100 bases:

>100_bases
CCCCTTGCCGCGAGCGCGCGTGTTCCCCCGCAAGCGGGAGGTGCCCCCAGTACGCCGACACACCGATTTTGATGTACCAG
TGCGGACCCTCGCGCAAGGA

Downstream 100 bases:

>100_bases
CACTGATCGTCCGGCTCTCCCCCACAAGCGGGCGGTACCCCCATCTCGGGCTGACTCCGGCCCGCGTCGTCGCCGGACTA
AGTTACTGGACGCCGTAGCC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAAMTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGID
RFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRST
AQVISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYS
SLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMA
LGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTP
PLLAGATKENAGG

Sequences:

>Translated_413_residues
MAAMTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGID
RFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRST
AQVISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYS
SLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMA
LGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTP
PLLAGATKENAGG
>Mature_412_residues
AAMTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDR
FVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTA
QVISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSS
LKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMAL
GWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPP
LLAGATKENAGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=302, Percent_Identity=36.7549668874172, Blast_Score=198, Evalue=9e-51,
Organism=Escherichia coli, GI1788618, Length=328, Percent_Identity=39.0243902439024, Blast_Score=232, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44931; Mature: 44800

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAMTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
SLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQIT
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCEEC
DLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYS
HCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHH
SLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
FIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHH
VVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG
HHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]