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The map label for this gene is ethA [H]

Identifier: 148824275

GI number: 148824275

Start: 3460268

End: 3461755

Strand: Direct

Name: ethA [H]

Synonym: TBFG_13100

Alternate gene names: 148824275

Gene position: 3460268-3461755 (Clockwise)

Preceding gene: 148824273

Following gene: 148824276

Centisome position: 78.21

GC content: 65.19

Gene sequence:

>1488_bases
ATGAACCAGCATTTCGACGTCCTGATCATCGGCGCCGGCCTATCCGGCATCGGGACGGCCTGTCACGTGACGGCCGAGTT
CCCCGACAAGACAATCGCCCTCCTGGAACGACGGGAGCGCCTGGGCGGCACCTGGGACTTGTTCCGCTACCCGGGAGTTC
GTTCGGACTCCGACATGTTCACCTTCGGCTACAAGTTCCGCCCGTGGCGCGACGTGAAGGTGCTCGCCGACGGCGCGTCG
ATCCGGCAGTACATCGCCGACACCGCCACGGAGTTCGGCGTCGACGAGAAGATTCACTACGGCCTGAAGGTCAACACCGC
CGAGTGGTCGAGCCGGCAGTGCCGTTGGACCGTCGCGGGCGTGCACGAGGCGACCGGCGAAACCCGGACCTACACCTGCG
ATTACCTCATCAGCTGCACCGGCTACTACAACTACGACGCGGGTTATCTGCCGGACTTCCCCGGCGTGCACCGGTTCGGC
GGCCGGTGCGTGCACCCGCAGCACTGGCCCGAAGACCTCGATTATTCCGGCAAGAAGGTCGTCGTCATCGGCAGCGGCGC
AACGGCGGTCACTTTGGTTCCGGCGATGGCCGGCTCCAACCCCGGCAGTGCCGCGCACGTGACGATGCTGCAGCGATCCC
CGTCGTACATCTTCTCGCTGCCGGCGGTCGACAAGATCTCCGAAGTCCTGGGCCGCTTCCTGCCGGATCGCTGGGTCTAC
GAGTTTGGCCGCAGGCGCAACATCGCCATCCAGCGAAAGCTCTACCAGGCCTGCCGGCGCTGGCCCAAGCTGATGCGGCG
ATTGCTGCTGTGGGAGGTACGACGCCGCCTCGGCCGCTCCGTGGACATGAGCAACTTCACCCCGAACTACCTGCCGTGGG
ACGAGCGGTTGTGCGCCGTGCCCAACGGCGATCTGTTTAAGACGCTGGCCTCGGGCGCGGCGTCGGTGGTGACCGATCAG
ATCGAGACCTTCACCGAGAAGGGCATCCTGTGCAAGTCCGGCCGGGAGATCGAGGCCGACATCATCGTCACCGCGACCGG
TCTGAACATCCAGATGCTGGGCGGGATGCGACTCATCGTGGACGGCGCCGAATACCAGCTGCCGGAGAAGATGACCTATA
AGGGTGTGCTGCTGGAAAACGCCCCCAATCTGGCCTGGATCATCGGCTACACCAACGCGTCATGGACCCTGAAGTCCGAC
ATCGCCGGCGCCTACCTGTGCCGGCTGCTGCGGCACATGGCCGACAACGGCTACACGGTGGCAACGCCGCGCGATGCGCA
GGACTGCGCGCTGGACGTTGGCATGTTCGACCAGCTGAACTCCGGCTATGTGAAGCGCGGCCAGGACATCATGCCGCGCC
AGGGCTCCAAGCATCCGTGGAGGGTGCTCATGCACTACGAGAAGGACGCCAAGATCCTGCTCGAAGACCCCATCGATGAC
GGCGTGCTGCACTTCGCCGCAGCGGCCCAAGACCACGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGATGAGGCTGCCCAGCTCCATCACCTCCTGTCGGAAAATGATAAAAGGCTGTCGCAAAGTGTCAATACGTGGCGGGGG
TCCTCCACCATGCTGGAGCC

Downstream 100 bases:

>100_bases
GCATCATGAACCTGCGCAAAAACGTCATCCGGTCCGTATTACGTGGTGCCCGGCCACTGTTCGCTTCCCGCCGGCTGGGT
ATTGCCGGCCGTCGAGTCCT

Product: monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
IRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA

Sequences:

>Translated_495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
IRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA
>Mature_495_residues
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGAS
IRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFG
GRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQ
IETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSD
IAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
GVLHFAAAAQDHAAA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=361, Percent_Identity=23.8227146814404, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55483; Mature: 55483

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF
CCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCEE
TFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAG
EEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECEEEECCCCCCCCEEEEEEE
VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV
CHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EEEECCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHH
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEC
PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV
CCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEEECCEEEEECCEEEEE
DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV
ECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCEEE
ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
ECCCCHHHHEECCCHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCC
GVLHFAAAAQDHAAA
CHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMF
CCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCEE
TFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAG
EEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECEEEECCCCCCCCEEEEEEE
VHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKV
CHHCCCCCEEEEEEEEEEEEEEECCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCCCEE
VVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVY
EEEECCCCEEEEEEHHCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHCCHHHHH
EFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEC
PNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIV
CCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEEECCEEEEECCEEEEE
DGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTV
ECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCCEEE
ATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDD
ECCCCHHHHEECCCHHHHCCCCHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCC
GVLHFAAAAQDHAAA
CHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA