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The map label for this gene is iclR [H]

Identifier: 148824179

GI number: 148824179

Start: 3357856

End: 3358557

Strand: Direct

Name: iclR [H]

Synonym: TBFG_13004

Alternate gene names: 148824179

Gene position: 3357856-3358557 (Clockwise)

Preceding gene: 148824175

Following gene: 148824181

Centisome position: 75.89

GC content: 71.94

Gene sequence:

>702_bases
GTGAGACAGCATAGCGGTATCGGTGTCCTCGACAAAGCCGTTGGCGTGCTGCACGCGGTCGCGGAATCTCCCTGCGGACT
GGCCGAACTCTGCGATCGAACCGACCTGCCCAGGGCCACCGCATACCGGCTGGCGGCCGCGCTGGAGGTGCATCGCCTGC
TGGGGCGCGGCCAGGATGGCCACTGGCGGCTCGGTCCGGCCATCACCGAACTCGCGACCCATGTCGACGATCCACTGCTG
GTGGCGTGCGCGGCGGTACTGCCTCAGCTGCGCGACGCCACCGGCGAAAGCGTGCAGGTATATCGCCGCGAGGGAACGTC
GCGGGTCTGCGTGGCCGCATTGGAACCAGCTGCGGGCCTTCGCGATACGGTCCCGGTCGGGGCACGGTTGCCGATGACCG
CGGGCTCGGGCGCCAAAGTGTTGCTGGCCCACACCGACGCCGCCACCCAAGCGGCCGTATTGCCAAAGGCGGTGTTCAGC
GCCCGAGCGCTGGCCGAGGTGTGCCGGCGCGGCTGGGCGCAAAGCGTGGCCGAACGCGAGCCTGGCGTGGCGAGCGTGTC
GGCGCCGGTGCGCGACGGCCGGGGCGTCGTGATCGCTGCCATCTCGGTGTCCGGCCCGATCGACCGGATGGGCCGCCGCC
CGGGGGTCCGATGGGCCGCCGACCTGCTGTCCGCGGCGGACGCGCTCACCCGACGGCTCTAG

Upstream 100 bases:

>100_bases
GTGCGTGGCTCGCCGGTCTGCAAGGCCATCTCGAAGTGCCTCTATTCATTCGTTCGCGACTCGCTGGTCATCTCAAAATA
CGAGACGCTATGATCTCTTT

Downstream 100 bases:

>100_bases
CCGCGTTGTGCTACATCGGTTCGACCGCGATCACATAGTCATTGCCGTGCCACAGACCGTCTTGCCGCTCGTTGAGCTGC
AATGCCCGAGCGCGCAGTTC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDPLL
VACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFS
ARALAEVCRRGWAQSVAEREPGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL

Sequences:

>Translated_233_residues
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDPLL
VACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFS
ARALAEVCRRGWAQSVAEREPGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL
>Mature_233_residues
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDGHWRLGPAITELATHVDDPLL
VACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGLRDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFS
ARALAEVCRRGWAQSVAEREPGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=249, Percent_Identity=25.7028112449799, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87082359, Length=241, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786715, Length=226, Percent_Identity=25.2212389380531, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788581, Length=221, Percent_Identity=26.6968325791855, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 24316; Mature: 24316

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDG
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
HWRLGPAITELATHVDDPLLVACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGL
CEECCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCC
RDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFSARALAEVCRRGWAQSVAERE
CCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL
CCCEECCCCCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQHSGIGVLDKAVGVLHAVAESPCGLAELCDRTDLPRATAYRLAAALEVHRLLGRGQDG
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
HWRLGPAITELATHVDDPLLVACAAVLPQLRDATGESVQVYRREGTSRVCVAALEPAAGL
CEECCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCC
RDTVPVGARLPMTAGSGAKVLLAHTDAATQAAVLPKAVFSARALAEVCRRGWAQSVAERE
CCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGVASVSAPVRDGRGVVIAAISVSGPIDRMGRRPGVRWAADLLSAADALTRRL
CCCEECCCCCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]