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The map label for this gene is cofC

Identifier: 148824173

GI number: 148824173

Start: 3350827

End: 3351471

Strand: Direct

Name: cofC

Synonym: TBFG_12998

Alternate gene names: 148824173

Gene position: 3350827-3351471 (Clockwise)

Preceding gene: 148824170

Following gene: 148824174

Centisome position: 75.73

GC content: 69.61

Gene sequence:

>645_bases
ATGAGCGGCACACCGGACGACGGCGATATCGGCTTGATCATCGCCGTCAAGCGCTTGGCCGCGGCCAAAACCAGGCTGGC
CCCGGTGTTCTCGGCGCAGACTCGCGAGAACGTGGTGCTGGCCATGCTCGTCGACACGTTGACCGCCGCGGCGGGTGTCG
GTTCACTGCGCTCGATCACTGTTATCACCCCCGACGAAGCCGCGGCGGCTGCGGCGGCCGGGCTGGGCGCCGATGTACTG
GCCGACCCGACACCCGAAGACGATCCCGACCCACTGAACACCGCCATCACCGCTGCCGAACGCGTGGTTGCCGAAGGGGC
CTCCAACATCGTTGTGCTGCAAGGCGATTTGCCGGCATTACAGACACAGGAACTCGCCGAGGCAATCTCGGCCGCACGCC
ACCATCGGCGCAGCTTCGTCGCCGACCGGCTTGGGACCGGCACCGCGGTACTGTGTGCGTTCGGCACCGCGCTGCACCCG
CGGTTCGGGCCGGATTCGTCCGCGCGGCACCGCCGTTCGGGCGCTGTCGAGCTGACAGGAGCCTGGCCGGGCCTGCGCTG
CGATGTCGACACCCCCGCCGACCTGACGGCCGCACGCCAGCTCGGGGTAGGGCCCGCGACCGCGCGAGCGGTCGCACATC
GTTGA

Upstream 100 bases:

>100_bases
GCCGCGGTTGCCGTCGGGACCGTGCCTGGGCCCCGGCCACGACCGTGGCGGCAATGCCGTCGAAGTGTGCCGCGTGGATC
GACGCTGGCAGGATGACTTC

Downstream 100 bases:

>100_bases
CCGGGACGGGGCAACGCCGGCGAGGCATCCAGGGGGTGAACGGCAGACCAACGGCGAACGGATGCCTGCCGAGTGCTGGC
AACCCCACCCAATGATGAGC

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVL
ADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHP
RFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR

Sequences:

>Translated_214_residues
MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVL
ADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHP
RFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
>Mature_213_residues
SGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLA
DPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPR
FGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_MYCBO (Q7TXH8)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856652.1
- ProteinModelPortal:   Q7TXH8
- SMR:   Q7TXH8
- EnsemblBacteria:   EBMYCT00000016098
- GeneID:   1094088
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3007
- GeneTree:   EBGT00050000017164
- HOGENOM:   HBG699055
- OMA:   LNADLPA
- ProtClustDB:   CLSK792205
- BioCyc:   MBOV233413:MB3007-MONOMER
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 21819; Mature: 21688

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSIT
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
VITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPAL
EECCCHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
QTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFGPDSSARHRRSGAVELTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEE
AWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
CCCCCEECCCCCCHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
SGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSIT
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
VITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPAL
EECCCHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
QTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFGPDSSARHRRSGAVELTG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEE
AWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
CCCCCEECCCCCCHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972