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The map label for this gene is ffh

Identifier: 148824105

GI number: 148824105

Start: 3236237

End: 3237814

Strand: Reverse

Name: ffh

Synonym: TBFG_12930

Alternate gene names: 148824105

Gene position: 3237814-3236237 (Counterclockwise)

Preceding gene: 148824107

Following gene: 148824104

Centisome position: 73.18

GC content: 66.35

Gene sequence:

>1578_bases
GTGTTTGAATCGCTGTCTGACCGTTTGACCGCCGCCCTGCAGGGGCTGCGCGGCAAGGGCCGACTGACCGATGCCGATAT
CGATGCCACTACCCGCGAAATTCGGTTGGCGCTGCTGGAAGCCGATGTTTCGCTACCGGTGGTCCGGGCATTCATCCACC
GGATCAAAGAACGCGCCCGCGGGGCCGAGGTGTCAAGTGCCCTCAACCCGGCTCAACAGGTCGTCAAGATCGTCAACGAG
GAACTGATAAGCATCCTCGGCGGCGAAACCCGCGAGTTGGCGTTTGCGAAGACCCCGCCGACCGTCGTGATGCTCGCCGG
CCTGCAGGGCTCCGGGAAGACGACACTGGCCGGCAAATTGGCCGCCCGCCTGCGTGGACAAGGACACACGCCACTGCTGG
TCGCTTGTGACCTGCAACGGCCGGCCGCGGTGAACCAGCTGCAGGTCGTCGGCGAGCGTGCCGGAGTGCCGGTGTTCGCG
CCGCATCCGGGTGCCTCGCCGGAGTCCGGCCCCGGTGACCCGGTTGCGGTGGCGGCGGCCGGGCTGGCCGAGGCCCGGGC
CAAGCACTTCGACGTCGTCATCGTCGACACCGCCGGACGACTGGGCATCGACGAGGAGCTGATGGCCCAGGCCGCGGCCA
TCCGCGACGCCATCAACCCCGACGAGGTGCTGTTCGTCCTGGACGCGATGATCGGCCAGGACGCGGTCACCACCGCTGCG
GCGTTCGGCGAGGGCGTCGGGTTCACCGGTGTGGCCTTGACCAAGCTCGACGGTGACGCCCGCGGTGGTGCCGCGTTATC
GGTGCGCGAAGTGACCGGTGTTCCAATCCTTTTCGCCTCCACCGGGGAGAAGCTGGAGGACTTCGACGTCTTCCACCCGG
ACCGGATGGCCAGTCGCATCTTGGGCATGGGCGATGTGCTGAGCCTGATCGAACAGGCCGAGCAGGTCTTCGATGCACAA
CAGGCCGAGGAGGCCGCAGCCAAGATCGGCGCCGGCGAGCTGACCCTGGAGGACTTCCTCGAGCAGATGCTCGCGGTACG
CAAGATGGGCCCGATCGGCAACCTGCTGGGCATGCTGCCCGGCGCGGCTCAGATGAAGGACGCGTTGGCCGAGGTCGACG
ACAAACAACTCGATCGTGTCCAGGCCATCATTCGCGGCATGACGCCGCAGGAACGGGCAGACCCCAAGATCATCAATGCC
TCGCGGCGGCTGCGCATCGCCAACGGCTCGGGCGTCACGGTGTCCGAGGTCAACCAGCTGGTCGAGCGCTTCTTCGAAGC
CCGCAAGATGATGTCGTCCATGCTCGGGGGCATGGGCATACCGGGCATAGGGCGCAAATCCGCGACGCGAAAGAGCAAGG
GCGCAAAAGGCAAATCCGGCAAGAAGAGTAAGAAGGGGACGCGCGGTCCGACGCCGCCGAAGGTCAAGAGCCCGTTCGGC
GTGCCCGGGATGCCGGGCTTGGCTGGGCTACCTGGGGGGCTCCCTGATCTCTCACAGATGCCCAAAGGTCTCGACGAGCT
GCCGCCCGGCCTGGCCGACTTCGACCTGTCCAAGCTGAAGTTCCCAGGCAAGAAGTAG

Upstream 100 bases:

>100_bases
TCCACCAGGCGGGTTACTCGCACTTTTGCGTGGTGGACGCAGAGTCAACGGATAACGGTGCCGCTGCGCGGCGCTCGCGA
TCACCATTAGGCTGGCGGGC

Downstream 100 bases:

>100_bases
TGGCGATCGCGAGTGCGGCGGAGCCGGGTGAAGCGGGTCGACACCATCAGGCCCCGTAGCCGCGCCGTGCGCCTGCACGT
GCGAGGTTTGGGCCTGCCCG

Product: signal recognition particle protein ffh

Products: NA

Alternate protein names: Fifty-four homolog

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNE
ELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA
AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQ
QAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG
VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Sequences:

>Translated_525_residues
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNE
ELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA
AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQ
QAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG
VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK
>Mature_525_residues
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNE
ELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFA
PHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA
AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQ
QAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINA
SRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG
VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=504, Percent_Identity=30.3571428571429, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI226371618, Length=446, Percent_Identity=30.7174887892377, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=39.5833333333333, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=29.6052631578947, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=29.6052631578947, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=51.0538641686183, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1789874, Length=271, Percent_Identity=37.2693726937269, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=410, Percent_Identity=30.9756097560976, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=300, Percent_Identity=30.3333333333333, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=496, Percent_Identity=33.0645161290323, Blast_Score=249, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6320498, Length=213, Percent_Identity=31.924882629108, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=30.4054054054054, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24641198, Length=321, Percent_Identity=27.1028037383178, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_MYCBO (P66845)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856585.1
- ProteinModelPortal:   P66845
- SMR:   P66845
- EnsemblBacteria:   EBMYCT00000016680
- GeneID:   1092166
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2940c
- GeneTree:   EBGT00050000014984
- HOGENOM:   HBG562580
- OMA:   IINGSRR
- ProtClustDB:   PRK10867
- BioCyc:   MBOV233413:MB2940C-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- PANTHER:   PTHR11564:SF7
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963
- TIGRFAMs:   TIGR00959

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 55002; Mature: 55002

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERAR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKL
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHH
AARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHH
GLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHH
AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRI
HHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHCCCCCHHHHHHHH
LGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLP
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
GAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQL
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCCHHHHHHH
VERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK
CCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERAR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKL
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCHHHHHH
AARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHH
GLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAA
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHH
AFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRI
HHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHCCCCCHHHHHHHH
LGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLP
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
GAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQL
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHCCCCEECCCCEEEEECCCCCCHHHHHHH
VERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK
CCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972