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The map label for this gene is pyrH

Identifier: 148824072

GI number: 148824072

Start: 3203902

End: 3204687

Strand: Reverse

Name: pyrH

Synonym: TBFG_12897

Alternate gene names: 148824072

Gene position: 3204687-3203902 (Counterclockwise)

Preceding gene: 148824074

Following gene: 148824071

Centisome position: 72.43

GC content: 65.01

Gene sequence:

>786_bases
ATGACAGAGCCCGATGTCGCCGGCGCGCCGGCTTCGAAGCCGGAGCCTGCGAGCACTGGCGCCGCGTCGGCGGCTCAGCT
GTCCGGGTACTCGCGAGTGTTGCTCAAGCTCGGCGGGGAAATGTTCGGCGGAGGCCAGGTCGGGCTGGATCCCGATGTCG
TCGCGCAGGTGGCCCGCCAGATCGCCGATGTGGTGCGCGGCGGCGTCCAGATCGCCGTCGTGATCGGCGGCGGCAACTTT
TTCCGGGGCGCACAGCTGCAGCAGCTCGGTATGGAGCGCACCAGGTCGGACTATATGGGAATGCTCGGCACTGTCATGAA
CAGCCTTGCACTGCAAGACTTCCTGGAGAAGGAAGGCATCGTTACCCGAGTCCAGACCGCGATCACCATGGGCCAGGTGG
CCGAACCGTACCTGCCGTTGCGGGCCGTCCGCCACCTGGAGAAGGGACGGGTGGTGATCTTCGGTGCCGGCATGGGGCTG
CCGTACTTTTCGACGGATACCACCGCAGCGCAGCGTGCGCTGGAGATCGGTGCCGACGTGGTCTTGATGGCCAAAGCGGT
CGACGGTGTGTTTGCTGAGGATCCGCGGGTGAACCCCGAGGCCGAACTGCTCACCGCCGTCAGTCATCGTGAGGTCCTCG
ACCGCGGGCTGCGAGTAGCCGACGCCACCGCGTTCAGCCTTTGCATGGACAATGGCATGCCGATCCTGGTGTTCAACCTG
CTGACCGATGGCAATATCGCCCGTGCTGTTCGGGGTGAGAAGATCGGAACGCTGGTCACCACCTAA

Upstream 100 bases:

>100_bases
TGACTAACGCACCCCGCCCACGCCGGAGCGCGGCTATTGAGGCAGGATGTGAGATGCCGTCCTGGTGGTGCCGGGATGGC
ACTGTCGTGCGAGGAGTCAG

Downstream 100 bases:

>100_bases
GGGGACTACGCGCTGCTTCGCGCCGGCGACGATGCAGAGCGCAGCGATGAGGAGGAGCGGCGCAGATGGTTGGCGCCGGC
GACGATGCAGAGCGCAGCGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNF
FRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGL
PYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNL
LTDGNIARAVRGEKIGTLVTT

Sequences:

>Translated_261_residues
MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNF
FRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGL
PYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNL
LTDGNIARAVRGEKIGTLVTT
>Mature_260_residues
TEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFF
RGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLP
YFSTDTTAAQRALEIGADVVLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLL
TDGNIARAVRGEKIGTLVTT

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=45.6896551724138, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MYCBO (P65930)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856552.1
- ProteinModelPortal:   P65930
- SMR:   P65930
- EnsemblBacteria:   EBMYCT00000015298
- GeneID:   1092201
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2907c
- GeneTree:   EBGT00050000017541
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   MBOV233413:MB2907C-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27430; Mature: 27299

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 78-78 BINDING 82-82 BINDING 97-97 BINDING 191-191 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQ
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGI
HHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADV
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
VLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNL
EEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEE
LTDGNIARAVRGEKIGTLVTT
ECCCCHHHHHCCCCCCCEECC
>Mature Secondary Structure 
TEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGI
HHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADV
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
VLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNL
EEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEE
LTDGNIARAVRGEKIGTLVTT
ECCCCHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972