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The map label for this gene is pgsA2

Identifier: 148823934

GI number: 148823934

Start: 3070557

End: 3071186

Strand: Reverse

Name: pgsA2

Synonym: TBFG_12759

Alternate gene names: 148823934

Gene position: 3071186-3070557 (Counterclockwise)

Preceding gene: 148823937

Following gene: 148823933

Centisome position: 69.41

GC content: 61.9

Gene sequence:

>630_bases
ATGAGCAGGTCAACCCGTTATTCTGTTGCCGTGTCGGCGCAGCCTGAAACGGGTCAGATAGCAGGCCGCGCCCGCATTGC
CAACCTCGCCAATATCCTGACGCTGTTGCGGCTGGTGATGGTCCCGGTCTTCCTGCTGGCCTTGTTCTATGGCGGCGGCC
ACCACTCCGCGGCCCGCGTAGTGGCGTGGGCGATATTTGCAACCGCCTGCATTACCGATCGATTCGACGGCCTGCTGGCT
CGCAATTACGGGATGGCAACCGAATTCGGTGCGTTTGTCGATCCGATCGCGGACAAGACTCTGATCGGCTCGGCGCTGAT
CGGATTGTCGATGCTCGGCGACTTGCCGTGGTGGGTCACGGTGCTAATCCTGACCCGCGAACTCGGAGTGACCGTTTTGA
GGTTGGCGGTTATTAGGCGCGGTGTCATTCCCGCGAGCTGGGGCGGCAAGCTGAAGACCTTTGTCCAGGCGGTGGCAATT
GGCTTATTCGTGTTGCCACTTTCGGGTCCGCTGCACGTTGCGGCGGTGGTAGTGATGGCCGCCGCGATCCTGCTCACCGT
GATCACTGGTGTCGATTACGTGGCCAGGGCTCTGCGGGACATCGGGGGGATCCGCCAGACCGCCAGCTGA

Upstream 100 bases:

>100_bases
TGATCGCGGGCACATCGGAGGTTCGCGCGCGCCGGACCACCGGCCGGCAATCCCGTGGACGTTCGGTCACGTGTGAAACA
GTATCGACATCAAGGGTCGC

Downstream 100 bases:

>100_bases
TTGCGGGAACCAACCCCACCGCCGGCGGCGTTCACCTGATGACGATTGCGAGGTGGACAAGGAGTTTTTGATGGCGGCTT
TGGTGCGTGAGGTCGTTGGT

Product: phosphatidylglycerophosphate synthase pgsA3

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARVVAWAIFATACITDRFDGLLA
RNYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVTVLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAI
GLFVLPLSGPLHVAAVVVMAAAILLTVITGVDYVARALRDIGGIRQTAS

Sequences:

>Translated_209_residues
MSRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARVVAWAIFATACITDRFDGLLA
RNYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVTVLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAI
GLFVLPLSGPLHVAAVVVMAAAILLTVITGVDYVARALRDIGGIRQTAS
>Mature_208_residues
SRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARVVAWAIFATACITDRFDGLLAR
NYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVTVLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAIG
LFVLPLSGPLHVAAVVVMAAAILLTVITGVDYVARALRDIGGIRQTAS

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family

Homologues:

Organism=Escherichia coli, GI1788220, Length=180, Percent_Identity=31.6666666666667, Blast_Score=91, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGSA2_MYCTU (O33288)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842580
- PIR:   A70879
- RefSeq:   NP_217262.1
- RefSeq:   NP_337323.1
- ProteinModelPortal:   O33288
- EnsemblBacteria:   EBMYCT00000000445
- EnsemblBacteria:   EBMYCT00000072605
- GeneID:   888375
- GeneID:   925460
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2817
- KEGG:   mtu:Rv2746c
- TIGR:   MT2817
- TubercuList:   Rv2746c
- GeneTree:   EBGT00050000016087
- HOGENOM:   HBG686655
- OMA:   AREFIIS
- ProtClustDB:   CLSK792050
- GO:   GO:0040007
- InterPro:   IPR000462
- InterPro:   IPR004570
- PIRSF:   PIRSF000847
- TIGRFAMs:   TIGR00560

Pfam domain/function: PF01066 CDP-OH_P_transf

EC number: =2.7.8.5

Molecular weight: Translated: 22137; Mature: 22005

Theoretical pI: Translated: 11.04; Mature: 11.04

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ca02db0)-; HASH(0x1c31d244)-; HASH(0x1be89c48)-; HASH(0x1c76864c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARV
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VAWAIFATACITDRFDGLLARNYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVT
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAIGLFVLPLSGPLHVAAVVVMA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AAILLTVITGVDYVARALRDIGGIRQTAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SRSTRYSVAVSAQPETGQIAGRARIANLANILTLLRLVMVPVFLLALFYGGGHHSAARV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VAWAIFATACITDRFDGLLARNYGMATEFGAFVDPIADKTLIGSALIGLSMLGDLPWWVT
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLILTRELGVTVLRLAVIRRGVIPASWGGKLKTFVQAVAIGLFVLPLSGPLHVAAVVVMA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AAILLTVITGVDYVARALRDIGGIRQTAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206