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The map label for this gene is 148823877

Identifier: 148823877

GI number: 148823877

Start: 3015990

End: 3016703

Strand: Reverse

Name: 148823877

Synonym: TBFG_12702

Alternate gene names: NA

Gene position: 3016703-3015990 (Counterclockwise)

Preceding gene: 148823878

Following gene: 148823876

Centisome position: 68.18

GC content: 64.43

Gene sequence:

>714_bases
ATGACCCGGTTGGTGCCTGCGCTGCGGCTCGAGCTGACGCTACAGGTGCGGCAGAAGTTCTTGCATGCCGCCGTTTTCTC
CGGACTGATTTGGCTGGCAGTGCTGCTGCCGATGCCGGTCAGCCTGCGCCCGGTCGCCGAACCCTATGTCCTGGTGGGTG
ATATCGCGATCATCGGGTTCTTCTTCGTCGGCGGGACCGTGTTCTTCGAGAAGCAGGAGCGCACGATCGGCGCGATCGTC
TCGACGCCGCTGCGGTTCTGGGAGTACCTGGCTGCCAAACTAACTGTGCTGCTGGCGATCTCGCTGTTCGTTGCGGTTGT
CGTGGCCACCATCGTTCACGGGCTTGGTTACCACCTGCTGCCGCTGGTGGCCGGCATCGTGCTGGGCACACTGCTGATGC
TGCTGGTCGGCTTCAGTTCCTCGTTGCCGTTCGCCTCGGTGACCGATTGGTTCCTGGCGGCGGTCATCCCGCTCGCGATC
ATGCTGGCGCCGCCGGTGGTGCACTACTCCGGCCTGTGGCCCAACCCGGTGCTTTACCTCATCCCCACCCAGGGGCCGCT
GCTCTTGCTCGGCGCGGCGTTCGATCAGGTGAGCTTGGCGCCCTGGCAGGTCGGGTATGCGGTGGTCTACCCAATCGTGT
GTGCGGCGGGATTGTGCCGGGCGGCCAAGGCGCTATTCGGCCGTTATGTCGTGCAAAGATCGGGTGTGCTGTGA

Upstream 100 bases:

>100_bases
CGTTCCACTCCGTGCTGCGAAACCACCACGTCGAGACCATTCATAGCCGCGAGGCCAGCCTCGACGATGTCTTCGTCGAG
GTCACCGGCAGGCAGCTGAC

Downstream 100 bases:

>100_bases
GAGCGATATCGAGCCTTGCGGGCCCACGGGCGTTGGCCGCGTTCGGCCGCAACGACATTCGAGGCACCTACCGCGATCCG
CTGCTGGTCATGCTCGTCAT

Product: antibiotic ABC transporter integral membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGFFFVGGTVFFEKQERTIGAIV
STPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLLPLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAI
MLAPPVVHYSGLWPNPVLYLIPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL

Sequences:

>Translated_237_residues
MTRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGFFFVGGTVFFEKQERTIGAIV
STPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLLPLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAI
MLAPPVVHYSGLWPNPVLYLIPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL
>Mature_236_residues
TRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGFFFVGGTVFFEKQERTIGAIVS
TPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLLPLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAIM
LAPPVVHYSGLWPNPVLYLIPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL

Specific function: Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the sub

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLQE3_MYCTU (O07189)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   B70529
- RefSeq:   NP_217203.1
- RefSeq:   NP_337262.1
- ProteinModelPortal:   O07189
- EnsemblBacteria:   EBMYCT00000000651
- EnsemblBacteria:   EBMYCT00000072650
- GeneID:   888446
- GeneID:   925536
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2761
- KEGG:   mtu:Rv2687c
- TIGR:   MT2761
- TubercuList:   Rv2687c
- GeneTree:   EBGT00050000017711
- HOGENOM:   HBG566756
- OMA:   VGTEIFA
- ProtClustDB:   CLSK792005

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 25576; Mature: 25445

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c9c9508)-; HASH(0x1c9a169c)-; HASH(0x1c87738c)-; HASH(0x1bc7a214)-; HASH(0x1c7ed8e4)-; HASH(0x1c97748c)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
FFVGGTVFFEKQERTIGAIVSTPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLL
HHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAIMLAPPVVHYSGLWPNPVLYL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEE
IPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL
EECCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
TRLVPALRLELTLQVRQKFLHAAVFSGLIWLAVLLPMPVSLRPVAEPYVLVGDIAIIGF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
FFVGGTVFFEKQERTIGAIVSTPLRFWEYLAAKLTVLLAISLFVAVVVATIVHGLGYHLL
HHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLVAGIVLGTLLMLLVGFSSSLPFASVTDWFLAAVIPLAIMLAPPVVHYSGLWPNPVLYL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEE
IPTQGPLLLLGAAFDQVSLAPWQVGYAVVYPIVCAAGLCRAAKALFGRYVVQRSGVL
EECCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036