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The map label for this gene is echA12 [H]

Identifier: 148823869

GI number: 148823869

Start: 3007019

End: 3007849

Strand: Direct

Name: echA12 [H]

Synonym: TBFG_12694

Alternate gene names: 148823869

Gene position: 3007019-3007849 (Clockwise)

Preceding gene: 148823864

Following gene: 148823870

Centisome position: 67.96

GC content: 68.11

Gene sequence:

>831_bases
ATGCCAGTTACCTACGACGACTTCCCCAGCCTGCGCTGCGAAATCCACGACCAACCTGGTCACGAAGGCGTGCTGGAGCT
GGTGCTGGACTCCCCCGGGCTGAACTCGGTCGGGCCGCACATGCACCGCGACCTTGCCGACATCTGGCCGGTGATCGATC
GCGACCCGGCCGTGCGCGTGGTCTTGGTCCGCGGTGAAGGCAAGGCCTTTTCCTCCGGCGGCAGTTTCGACCTGATCGCC
GAAACCATCGGCGACTACCAGGGCCGGCTGCGCATCATGCGCGAGGCCCGCGACCTGGTGCTCAACCTGGTCAACTTCGA
CAAGCCGGTGGTGTCGGCGATTCGGGGCCCGGCCGTCGGTGCGGGTCTGGTTGTCGCGCTGCTCGCCGACATTTCGGTGG
CGGGCCGCGCCGCGAAGATCATCGATGGGCACACCAAACTCGGGGTCGCCGCGGGGGATCACGCGGCGATCTGCTGGCCC
CTGCTGGTCGGCATGGCCAAGGCCAAGTACTACCTGCTGACCTGCGAGCCGCTGTCCGGGGAGGAGGCCGAACGCATCGG
TCTGGTCTCCATCTGCGTCGACGACGACGATGTGCTCCCCACCGCAACACGCCTGGCGGAGCGGCTCGCCGCTGGCGCGC
AAAACGCCATCCGCTGGACCAAACGCAGCCTCAATCACTGGTATCGCATGTTCGGTCCCGCCTTCGAAACGTCGCTCGGG
CTGGAGTTCATCGGGTTCGGTGGTCCCGACGTCCGGGAAGGCCTGGCCGCGCACCGCGAAAAGCGCCCCGCGCGGTTCGG
CGCCGACCCCGATCCCGGCGCCGGCAGCTGA

Upstream 100 bases:

>100_bases
GACGGCGGCCAGATACGGCGACTGCGGAAGGTCGCGACGGGTACTCATCGAACTCAATGCTGCCACGACCGCCACCCCGC
ACCTGCGTAACATCGACCCA

Downstream 100 bases:

>100_bases
GCACAGTTCGGCGCGCCTGTGCACACGTGTCGGCGGATAGGTCTACCGTCGAAATCTGTGACCTCCGCCGGCGACGATGC
AGAGCGCAGCGATGAGGAGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIA
ETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWP
LLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLG
LEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS

Sequences:

>Translated_276_residues
MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIA
ETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWP
LLVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLG
LEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
>Mature_275_residues
PVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRVVLVRGEGKAFSSGGSFDLIAE
TIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVGAGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWPL
LVGMAKAKYYLLTCEPLSGEEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLGL
EFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=257, Percent_Identity=25.6809338521401, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1787660, Length=253, Percent_Identity=31.6205533596838, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787659, Length=251, Percent_Identity=27.4900398406374, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI221142681, Length=215, Percent_Identity=28.3720930232558, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788597, Length=233, Percent_Identity=24.4635193133047, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=27.843137254902, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=258, Percent_Identity=28.6821705426357, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=26.6129032258064, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=214, Percent_Identity=23.3644859813084, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=214, Percent_Identity=28.5046728971963, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=272, Percent_Identity=27.2058823529412, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653477, Length=272, Percent_Identity=27.2058823529412, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=25.6830601092896, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24653139, Length=251, Percent_Identity=26.2948207171315, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29635; Mature: 29504

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRV
CCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEE
VLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVG
EEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCH
AGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSG
HHHHHHHHHHHHHCCCHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCC
EEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLG
CCHHHEEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHCC
LEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVTYDDFPSLRCEIHDQPGHEGVLELVLDSPGLNSVGPHMHRDLADIWPVIDRDPAVRV
CCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCEEE
VLVRGEGKAFSSGGSFDLIAETIGDYQGRLRIMREARDLVLNLVNFDKPVVSAIRGPAVG
EEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCH
AGLVVALLADISVAGRAAKIIDGHTKLGVAAGDHAAICWPLLVGMAKAKYYLLTCEPLSG
HHHHHHHHHHHHHCCCHHHEECCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEECCCCC
EEAERIGLVSICVDDDDVLPTATRLAERLAAGAQNAIRWTKRSLNHWYRMFGPAFETSLG
CCHHHEEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHCC
LEFIGFGGPDVREGLAAHREKRPARFGADPDPGAGS
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]