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The map label for this gene is rtcB [C]

Identifier: 148823825

GI number: 148823825

Start: 2970889

End: 2972187

Strand: Direct

Name: rtcB [C]

Synonym: TBFG_12650

Alternate gene names: 148823825

Gene position: 2970889-2972187 (Clockwise)

Preceding gene: 148823824

Following gene: 148823829

Centisome position: 67.15

GC content: 65.67

Gene sequence:

>1299_bases
ATGCAAGTGGTCAACGTGGCTACGCTGCCGGGGATTGTCCGGGCCTCGTATGCGATGCCCGATGTGCACTGGGGATATGG
TTTCCCAATCGGCGGCGTGGCCGCAACCGACGTCGACAATGATGGAGTCGTTTCCCCAGGCGGTGTCGGCTTCGATATTT
CGTGCGGCGTAAGACTCTTGGTCGGCGAAGGGCTGGACCGCGAGGAGCTGCAACCACGGTTGCCGGCGGTCATGGACCGG
CTTGATCGCGCGATACCGCGCGGAGTGGGCACGGCGGGTGTGTGGCGACTACCCGACCGGAACACGCTGCAGGAGGTGCT
CACCGGTGGTGCCCGGTTTGCGGTGGAACAGGGGCATGGCGTCGCGCTAGACCTCGAGCGGTGCGAAGACGGCGGTGTGA
TGACAGGAGCGGACGCGGCCAAAATCAGTGACCGGGCCCTCCAACGCGGGCTTGGGCAGATCGGCAGCCTTGGCTCGGGC
AACCACTTCCTGGAAGTCCAGGCCGTGGACCGCGTCTACGATCCGGTTGCGGCCGCGCCGATGGGTCTGGCGGAAGGGAC
CGTCTGCGTGATGATCCACACCGGCTCACGGGGCCTGGGCCATCAGATCTGCACGGATCACGTCCGCCAGATGGAACAAG
CCATGGGCCGATACGGAATCGCGGTGCCCGATCGCCAATTGGCTTGTGTGCCGGTGCACTCCCCCGATGGGCAGGCCTAT
CTCGCCGCGATGGCGGCGGCGGCCAACTACGGACGCGCCAACCGCCAACTGCTGACCGAGGCGACGCGTCGTGTGTTCGC
TGATGCAACCGGAACACCTCTGGACCTGCTCTACGACGTGTCGCACAACCTGGCCAAGATCGAGACGCATCCGATCGACG
GTCAGCTGCGCTCGGTGTGCGTGCACCGCAAGGGCGCCACCCGCTCGCTGCCGCCGCACCATCACGAGCTGCCGGCCGAA
CTGGCAGCGGTCGGCCAACCCGTGCTGATACCCGGGACGATGGGTACGGCGTCATATGTGCTTGCCGGGGTCACCGGCAA
CCCGGCGTTCTTTTCCACCGCGCATGGTGCTGGGCGGGTACTGAGCCGTCACCAGGCCGCCCGCCACACCAGCGGTGAAG
CGATACGCGCCAGCCTCGCAAAACGTGGCATCATCGTCCGCGGTACCTCTCGTAGGGGTATCGCCGAGGAAAAGCCGGAG
GCCTACAAAGACGTCGACGAGGTCATCGAAGCCAGCCATCAGAGTGGCCTCGCGCGCAAAGTGGCTCGCCTTGTTCCCTT
GGGCTGTGTCAAAGGATGA

Upstream 100 bases:

>100_bases
TACCGGTTCCGGATCGAACAAGAGGGCGCGATGCGGGTGCCCGGGATCGTGTTCGCGTCCAGGTCGTTGCTGCCTCGTGA
CGAAGGCGACATGGCCCTTG

Downstream 100 bases:

>100_bases
ATCAACGGCGAACATTCCAGCCGTCGCGACCGCCTTCTTCAGTGGTGCAGACCCGTGACCGGCTGATGGGTACTGGCTTC
GATATCCGACGACGTCAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDR
LDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSG
NHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAY
LAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAE
LAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPE
AYKDVDEVIEASHQSGLARKVARLVPLGCVKG

Sequences:

>Translated_432_residues
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDR
LDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSG
NHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAY
LAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAE
LAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPE
AYKDVDEVIEASHQSGLARKVARLVPLGCVKG
>Mature_432_residues
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDR
LDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSG
NHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAY
LAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAE
LAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPE
AYKDVDEVIEASHQSGLARKVARLVPLGCVKG

Specific function: Unknown

COG id: COG1690

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0027 (rtcB) family

Homologues:

Organism=Homo sapiens, GI7657015, Length=440, Percent_Identity=48.4090909090909, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI2367224, Length=446, Percent_Identity=29.1479820627803, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17506665, Length=440, Percent_Identity=47.0454545454545, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24585217, Length=440, Percent_Identity=48.1818181818182, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2631_MYCTU (P71930)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   C70963
- RefSeq:   NP_217147.2
- RefSeq:   NP_337208.1
- ProteinModelPortal:   P71930
- SMR:   P71930
- EnsemblBacteria:   EBMYCT00000000852
- EnsemblBacteria:   EBMYCT00000072233
- GeneID:   887431
- GeneID:   925603
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2707
- KEGG:   mtu:Rv2631
- TIGR:   MT2707
- TubercuList:   Rv2631
- GeneTree:   EBGT00050000018437
- HOGENOM:   HBG364447
- OMA:   AQSLFDH
- ProtClustDB:   CLSK881399
- InterPro:   IPR001233
- PANTHER:   PTHR11118

Pfam domain/function: PF01139 UPF0027; SSF103365 UPF0027

EC number: NA

Molecular weight: Translated: 45528; Mature: 45528

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS01288 UPF0027

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLL
CCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEECCCCEEEE
VGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHG
ECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCC
VALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSGNHFLEVQAVDRVYDPVAAAP
EEEEHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHCCHHHCC
MGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAY
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHH
LAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVC
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHH
VHRKGATRSLPPHHHELPAELAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRV
HHCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCEEEEECCCCCCEEECCCCHHHH
LSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPEAYKDVDEVIEASHQSGLARK
HHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VARLVPLGCVKG
HHHHHCCCCCCC
>Mature Secondary Structure
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLL
CCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEECCCCEEEE
VGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHG
ECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCC
VALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSGNHFLEVQAVDRVYDPVAAAP
EEEEHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHCCHHHCC
MGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAY
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHH
LAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVC
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHH
VHRKGATRSLPPHHHELPAELAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRV
HHCCCCCCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCEEEEECCCCCCEEECCCCHHHH
LSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPEAYKDVDEVIEASHQSGLARK
HHHHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VARLVPLGCVKG
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036