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The map label for this gene is 148823819

Identifier: 148823819

GI number: 148823819

Start: 2964639

End: 2965820

Strand: Reverse

Name: 148823819

Synonym: TBFG_12644

Alternate gene names: NA

Gene position: 2965820-2964639 (Counterclockwise)

Preceding gene: 148823820

Following gene: 148823818

Centisome position: 67.03

GC content: 65.99

Gene sequence:

>1182_bases
ATGCGTGATGCGATCCCGCTTGGGCGGATCGCCGGGTTTGTGGTGAACGTCCACTGGAGCGTGTTGGTGATCCTGTGGTT
GTTCACCTGGAGTCTGGCGACCATGTTGCCGGGTACCGTCGGAGGCTACCCGGCCGTGGTCTATTGGCTTCTCGGCGCAG
GTGGCGCGGTCATGTTGCTGGCGTCGCTGTTGGCTCATGAGCTCGCGCACGCCGTCGTCGCTCGTCGCGCCGGGGTATCC
GTTGAGAGCGTGACGTTGTGGCTGTTCGGCGGGGTGACCGCGCTTGGCGGCGAGGCAAAGACGCCCAAAGCCGCTTTCCG
GATCGCGTTCGCGGGTCCGGCTACCAGCCTGGCGCTGTCGGCGACATTCGGTGCGTTGGCCATCACGCTCGCCGGCGTGC
GGACCCCGGCCATCGTGATCAGCGTTGCTTGGTGGTTGGCTACTGTCAACCTGCTGCTGGGGCTGTTCAATCTGCTGCCT
GGCGCGCCGTTGGACGGTGGGCGGTTGGTCCGGGCCTATCTGTGGCGCCGCCACGGCGATAGTGTGCGCGCCGGGATCGG
TGCGGCGCGGGCCGGACGGGTGGTTGCGCTGGTCTTGATCGCGTTGGGATTGGCCGAGTTTGTGGCTGGTGGCCTCGTCG
GTGGGGTCTGGTTAGCCTTCATTGGCTGGTTTATCTTCGCTGCCGCTCGCGAGGAGGAGACCCGGATTTCGACCCAGCAG
CTGTTTGCCGGGGTGCGTGTGGCCGATGCGATGACCGCCCAACCGCATACGGCTCCCGGATGGATCAATGTCGAGGATTT
CATCCAGCGTTACGTGCTTGGTGAACGGCACTCGGCATATCCGGTTGCCGATCGGGACGGATCGATCACGGGCCTGGTGG
CATTGCGGCAGCTGCGCGATGTTGCGCCTAGCCGGCGCAGCACTACCAGCGTAGGTGACATTGCGCTGCCGCTGCACAGC
GTGCCGACCGCCCGACCACAAGAGCCGCTGACCGCGCTCCTAGAGCGGATGGCACCGCTCGGCCCGCGCAGCCGTGCGCT
GGTCACCGAAGGGAGCGCGGTGGTCGGCATCGTCACTCCCAGCGATGTCGCGCGGCTGATTGACGTCTACCGGTTGGCCC
AGCCGGAACCGACCTTTACCACGAGTCCCCAAGATGCGGACAGGTTTTCCGATGCGGGGTGA

Upstream 100 bases:

>100_bases
TTCGTCAAGGCAATCTGCTCGCCCATGGCCCTCGCCAGCTAGCGACCTCGGATCATCCGCCGGCACGAAAGGCTTTATCC
GCCAGCATCGGAGGTACCCA

Downstream 100 bases:

>100_bases
TCGAGCATCGGGAAATGTCTGGGAGAGGAGAGCCGACGATGAAAACAATCATTGTTGGTATCGATGGTTCGCACGCGGCG
ATTACGGCCGCATTGTGGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVS
VESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLP
GAPLDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ
LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHS
VPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG

Sequences:

>Translated_393_residues
MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVS
VESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLP
GAPLDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ
LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHS
VPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG
>Mature_393_residues
MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLLASLLAHELAHAVVARRAGVS
VESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALSATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLP
GAPLDGGRLVRAYLWRRHGDSVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ
LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRDVAPSRRSTTSVGDIALPLHS
VPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTPSDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG

Specific function: Unknown

COG id: COG1994

COG function: function code R; Zn-dependent proteases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2625_MYCTU (O06187)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842580
- PIR:   H70572
- RefSeq:   NP_217141.1
- RefSeq:   NP_337202.1
- ProteinModelPortal:   O06187
- SMR:   O06187
- MEROPS:   M50.006
- EnsemblBacteria:   EBMYCT00000003635
- EnsemblBacteria:   EBMYCT00000070604
- GeneID:   887692
- GeneID:   925609
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2700
- KEGG:   mtu:Rv2625c
- TIGR:   MT2700
- TubercuList:   Rv2625c
- GeneTree:   EBGT00050000018536
- HOGENOM:   HBG688956
- OMA:   FGASQEY
- ProtClustDB:   CLSK872086
- GO:   GO:0006508
- InterPro:   IPR000644
- InterPro:   IPR008915
- InterPro:   IPR016483
- PIRSF:   PIRSF006404
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF02163 Peptidase_M50

EC number: NA

Molecular weight: Translated: 41481; Mature: 41481

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS51371 CBS; PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 67-67

Signals:

None

Transmembrane regions:

HASH(0x1c8d8f30)-; HASH(0x1b98969c)-; HASH(0x1c1ea034)-; HASH(0x1c256a14)-; HASH(0x1c080220)-; HASH(0x1b08d67c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHH
ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS
HHHHHHHHHHHHHHHHCCCCHHHHHEEEECCHHHCCCCCCCCHHHEEEEECCCCHHHHHH
ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP
HCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECH
SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG
HHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCH
>Mature Secondary Structure
MRDAIPLGRIAGFVVNVHWSVLVILWLFTWSLATMLPGTVGGYPAVVYWLLGAGGAVMLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHH
ASLLAHELAHAVVARRAGVSVESVTLWLFGGVTALGGEAKTPKAAFRIAFAGPATSLALS
HHHHHHHHHHHHHHHHCCCCHHHHHEEEECCHHHCCCCCCCCHHHEEEEECCCCHHHHHH
ATFGALAITLAGVRTPAIVISVAWWLATVNLLLGLFNLLPGAPLDGGRLVRAYLWRRHGD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
SVRAGIGAARAGRVVALVLIALGLAEFVAGGLVGGVWLAFIGWFIFAAAREEETRISTQQ
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
LFAGVRVADAMTAQPHTAPGWINVEDFIQRYVLGERHSAYPVADRDGSITGLVALRQLRD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
VAPSRRSTTSVGDIALPLHSVPTARPQEPLTALLERMAPLGPRSRALVTEGSAVVGIVTP
HCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECH
SDVARLIDVYRLAQPEPTFTTSPQDADRFSDAG
HHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036