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The map label for this gene is aroB

Identifier: 148823733

GI number: 148823733

Start: 2874906

End: 2875994

Strand: Reverse

Name: aroB

Synonym: TBFG_12558

Alternate gene names: 148823733

Gene position: 2875994-2874906 (Counterclockwise)

Preceding gene: 148823734

Following gene: 148823732

Centisome position: 65.0

GC content: 68.69

Gene sequence:

>1089_bases
ATGACCGATATCGGCGCACCCGTGACCGTGCAGGTGGCCGTCGATCCGCCATACCCGGTGGTCATCGGTACCGGCCTGCT
CGACGAGCTGGAAGACCTGCTGGCCGACCGGCACAAGGTCGCCGTCGTGCATCAGCCCGGACTAGCCGAGACCGCGGAAG
AGATCCGAAAGCGCTTGGCCGGCAAGGGCGTCGACGCGCACCGCATCGAGATCCCCGACGCCGAGGCCGGCAAGGACCTG
CCCGTCGTGGGATTCATCTGGGAGGTGTTGGGCCGCATCGGAATCGGCCGCAAAGACGCCCTGGTCAGCCTCGGCGGCGG
GGCCGCCACCGACGTCGCCGGGTTCGCGGCGGCCACCTGGCTGCGCGGCGTCTCGATTGTGCACCTGCCCACCACACTGC
TGGGCATGGTCGATGCGGCCGTCGGCGGCAAGACCGGCATCAACACCGACGCCGGCAAGAACCTGGTCGGGGCGTTTCAT
CAGCCGTTGGCGGTCCTGGTGGACCTGGCGACGCTGCAAACCTTGCCACGCGACGAAATGATCTGCGGCATGGCCGAAGT
GGTCAAGGCCGGCTTCATCGCCGACCCGGTGATCCTGGATCTCATCGAAGCTGACCCGCAGGCCGCACTCGACCCGGCCG
GCGACGTGCTGCCCGAGCTGATCCGGCGCGCGATCACCGTCAAGGCCGAGGTGGTCGCCGCCGACGAAAAGGAATCCGAG
CTGCGCGAAATCCTCAACTACGGCCACACATTAGGCCACGCGATCGAGCGCCGGGAACGCTACCGGTGGCGCCACGGCGC
CGCCGTGTCGGTGGGGCTGGTGTTCGCGGCCGAGCTGGCCAGGCTTGCCGGGCGGCTCGACGACGCGACCGCGCAGCGCC
ACCGCACCATCCTGTCCTCGTTGGGATTGCCGGTCAGCTACGACCCGGACGCGCTGCCCCAGCTGCTGGAAATCATGGCC
GGCGACAAGAAGACTCGGGCGGGTGTGTTGCGGTTCGTGGTGCTCGACGGATTGGCCAAGCCGGGCCGAATGGTGGGACC
GGACCCCGGTCTGCTGGTAACCGCCTACGCCGGAGTTTGCGCCCCATGA

Upstream 100 bases:

>100_bases
TCGCGACCATGCGAGTGGACACCAATCGCCGCAACCCCGGGGCGGTGGTCCGCCATATCCTGTCGCGGCTGCAGGTTCCC
AGCCCCAGCGAGGCGGCCAC

Downstream 100 bases:

>100_bases
GCGAACTGATCGTGAACGTGATCAACGGCCCCAACCTGGGCCGGTTGGGCCGGCGCGAGCCCGCCGTCTATGGCGGCACC
ACCCACGACGAGCTGGTCGC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDL
PVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFH
QPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESE
LREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMA
GDKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP

Sequences:

>Translated_362_residues
MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDL
PVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFH
QPLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESE
LREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMA
GDKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP
>Mature_361_residues
TDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLAGKGVDAHRIEIPDAEAGKDLP
VVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATWLRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQ
PLAVLVDLATLQTLPRDEMICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESEL
REILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLGLPVSYDPDALPQLLEIMAG
DKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVCAP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=322, Percent_Identity=41.9254658385093, Blast_Score=212, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320332, Length=285, Percent_Identity=37.8947368421053, Blast_Score=176, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_MYCBO (P0A4Z5)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856213.1
- ProteinModelPortal:   P0A4Z5
- SMR:   P0A4Z5
- EnsemblBacteria:   EBMYCT00000015095
- GeneID:   1090913
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2567c
- GeneTree:   EBGT00050000016995
- HOGENOM:   HBG632303
- OMA:   FAAYQEI
- ProtClustDB:   PRK00002
- BioCyc:   MBOV233413:MB2567C-MONOMER
- BRENDA:   4.2.3.4
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 38120; Mature: 37988

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLA
CCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
GKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATW
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHHHHH
LRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEM
HHCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
ICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESE
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHH
LREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSS
HHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVC
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
AP
CC
>Mature Secondary Structure 
TDIGAPVTVQVAVDPPYPVVIGTGLLDELEDLLADRHKVAVVHQPGLAETAEEIRKRLA
CCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
GKGVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATW
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHHEEEECCCCHHHHHHHHHHHH
LRGVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEM
HHCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
ICGMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESE
HHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHH
LREILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSS
HHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLPVSYDPDALPQLLEIMAGDKKTRAGVLRFVVLDGLAKPGRMVGPDPGLLVTAYAGVC
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972