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The map label for this gene is mmuM [H]

Identifier: 148823658

GI number: 148823658

Start: 2774453

End: 2775361

Strand: Direct

Name: mmuM [H]

Synonym: TBFG_12483

Alternate gene names: 148823658

Gene position: 2774453-2775361 (Clockwise)

Preceding gene: 148823652

Following gene: 148823659

Centisome position: 62.71

GC content: 68.43

Gene sequence:

>909_bases
GTGGAATTGGTCAGCGATTCCGTGCTGATCAGCGATGGCGGCCTGGCCACCGAGCTTGAGGCGCGCGGTCACGACCTGTC
CGACCCGTTGTGGTCGGCGCGGCTGCTGGTGGACGCTCCGCACGCGATCACCGCGGTGCATACCGCGTACTTTCGCGCTG
GGGCCCAGATTGCCACGACTGCCAGCTACCAGGCCTCGTTCGAGGGCTTCGCGGCGCGCGGCATAGGTCATGACGACGCC
ACCGTGCTGCTGCGCCGCAGCGTCGAACTCGCCCAGGCTGCGCGCGACGAGGTCGGCGTTGGCGGTCTATCGGTCGCAGC
CTCGGTCGGGCCATACGGCGCCGCGCTGGCTGACGGATCCGAATACCGCGGATGCTACGGCCTGTCCGTCGCAGCCTTGA
TGAAGTGGCATCTGCCACGGCTCGAGGTGCTAGTCGATGCCGGCGCTGACATGCTCGCCCTGGAAACCATCCCCGATATC
GACGAAGCCGAAGCGCTGGTCAACCTGGTGCGGCGGTTGGCTACGCCGGCCTGGCTCAGCTACACGATCAACGGGACGCG
GACTCGCGCCGGGCAACCGCTCACCGACGCGTTTGCGGTGGCCGCAGGAGTTCCCGAGATCGTCGCCGTCGGCGTCAACT
GCTGCGCACCCGACGACGTGTTGCCGGCCATCGCTTTCGCCGTCGCCCACACAGGCAAACCGGTGATCGTGTACCCGAAC
AGCGGTGAGGGTTGGGATGGTCGGCGCCGCGCCTGGGTAGGTCCGCGGCGGTTTTCCGGATCTTCCGGGCAGCTTGCGCG
GGAATGGGTTGCGGCGGGCGCGCGCATCGTGGGCGGATGCTGCCGAGTACGGCCGATCGATATTGCCGAAATCGGGCGAG
CGCTGACCACCGCGCCGCCCCGAGGCTGA

Upstream 100 bases:

>100_bases
TCCGTGTCTCTGGCGTGTCGCGGTCGTAACCCCACCGAGGCCCGCGCGTCGCGGACCCGGCAGCGGCCCGACCGCCAGCT
GACCACCCTACAGTGGCGTT

Downstream 100 bases:

>100_bases
AAGCGAAAATTGCCTCTACTGCCTCATCGAGGCGTTACCTAGGGTTAGTTCTTGTGACCGCGAAGCCCGGCTACGCATGA
GTAAGAACCGCATTATGGGC

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDA
TVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDI
DEAEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN
SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG

Sequences:

>Translated_302_residues
MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDA
TVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDI
DEAEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN
SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG
>Mature_302_residues
MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATTASYQASFEGFAARGIGHDDA
TVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGSEYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDI
DEAEALVNLVRRLATPAWLSYTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN
SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPPRG

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=336, Percent_Identity=25.8928571428571, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786456, Length=298, Percent_Identity=47.6510067114094, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1790450, Length=334, Percent_Identity=25.1497005988024, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535405, Length=336, Percent_Identity=25, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324982, Length=316, Percent_Identity=26.8987341772152, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322966, Length=312, Percent_Identity=27.5641025641026, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6323983, Length=94, Percent_Identity=32.9787234042553, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585077, Length=315, Percent_Identity=33.968253968254, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI20129603, Length=318, Percent_Identity=35.2201257861635, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 31533; Mature: 31533

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT
CCCCCCCEEEECCCCEEEHHHCCCCCCCCHHHCEEEEECCHHHHHHHHHHHHCCCCEEEE
ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS
CHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCCC
EYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN
EEECCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECC
SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCHHCCCCCCHHHHHHHHCCCCC
RG
CC
>Mature Secondary Structure
MELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT
CCCCCCCEEEECCCCEEEHHHCCCCCCCCHHHCEEEEECCHHHHHHHHHHHHCCCCEEEE
ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS
CHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHCCCC
EYRGCYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEE
YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN
EEECCCCCCCCCCHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECC
SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCHHCCCCCCHHHHHHHHCCCCC
RG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]