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The map label for this gene is yfhR [C]

Identifier: 148823506

GI number: 148823506

Start: 2588639

End: 2589484

Strand: Reverse

Name: yfhR [C]

Synonym: TBFG_12329

Alternate gene names: 148823506

Gene position: 2589484-2588639 (Counterclockwise)

Preceding gene: 148823507

Following gene: 148823505

Centisome position: 58.53

GC content: 67.61

Gene sequence:

>846_bases
ATGTCGCTAAAGAGGTGTCGCGCGTTGCCGGTGGTCGCTATCGTCGCGCTGGTGGCATCGGGCGTGATTATGTTCATCTG
GTCGCAGCAGCGTCGGCTAATCTACTTCCCGTCTGCGGGTCCGGTGCCATCGGCTTCCTCCGTTTTGCCCGCCGGCCGCG
ATGTCGTGGTCGAAACACAAGATGGAATGCGCTTGGGTGGCTGGTACTTCCCGCATACTTCGGGCGGTAGTGGGCCCGCG
GTGCTGGTGTGCAATGGCAACGCCGGCGACCGGTCGATGCGTGCGGAGCTGGCTGTCGCGCTGCATGGCCTGGGCCTGTC
GGTGTTGCTGTTTGACTATCGCGGCTACGGCGGTAACCCGGGTCGGCCGTCTGAGCAGGGCCTGGCCGCCGACGCTCGGG
CCGCGCAGGAGTGGCTGTCCGGCCAGTCCGACGTCGACCCCGCGCGCATTGCCTATTTCGGCGAATCCCTCGGCGCGGCG
GTGGCGGTCGGGCTGGCCGTGCAACGGCCGCCGGCGGCACTCGTGCTGAGATCTCCGTTCACGTCGCTGGCCGAGGTCGG
CGCGGTGCACTACCCGTGGCTGCCGCTGCGCCGGTTGCTGCTGGACCACTACCCGTCGATCGAGCGCATCGCCTCTGTAC
ACGCGCCGGTGCTGGTCATCGCGGGCGGCAGCGACGACATCGTCCCCGCTACGCTTAGTGAGCGGCTGGTCGCAGCGGCC
GCCGAGCCTAAGCGATACGTGGTGGTTCCCGGTGTGGGTCACAACGACCCGGAACTACTCGATGGGCGGGTGATGCTCGA
TGCGATCCGGCGCTTCTTGACGGAGACGGCGGTGCTCGGACAGTGA

Upstream 100 bases:

>100_bases
CGTTGAATTTCGTGTCGATTTTCTGTTTGGAACGGTGGTTTCGGTAATCCACTGGTCGCGGGGACCCCGCTTTCGATGCG
TCGCACCGGTGCGGGGCTAG

Downstream 100 bases:

>100_bases
ACCGGGCATGACGACGCCCGCCGGTGTCCGGTGACTCGTGTGGCGTTGCTGACTACCGGTCGTGAGCTGAGCCAGGCCGC
ACCGCCGGCGCGGGCGCGCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPA
VLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAA
VAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAA
AEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ

Sequences:

>Translated_281_residues
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPA
VLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAA
VAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAA
AEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ
>Mature_280_residues
SLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAV
LVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAV
AVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAA
EPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ

Specific function: Unknown

COG id: COG1073

COG function: function code R; Hydrolases of the alpha/beta superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To S.pombe bem46 and yeast YNL320w

Homologues:

Organism=Homo sapiens, GI49355781, Length=266, Percent_Identity=29.6992481203008, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI194306564, Length=205, Percent_Identity=34.6341463414634, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194306562, Length=201, Percent_Identity=34.8258706467662, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71051602, Length=225, Percent_Identity=28.4444444444444, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71051600, Length=225, Percent_Identity=28.4444444444444, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI109689718, Length=185, Percent_Identity=34.5945945945946, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI24308097, Length=190, Percent_Identity=33.6842105263158, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI151301175, Length=216, Percent_Identity=32.4074074074074, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI32451492, Length=262, Percent_Identity=29.0076335877863, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI32528310, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI226510965, Length=267, Percent_Identity=31.0861423220974, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71988362, Length=202, Percent_Identity=35.6435643564356, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17566318, Length=309, Percent_Identity=24.2718446601942, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997133, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324009, Length=278, Percent_Identity=29.136690647482, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137566, Length=281, Percent_Identity=32.7402135231317, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281362521, Length=206, Percent_Identity=31.5533980582524, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281362519, Length=206, Percent_Identity=31.5533980582524, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571878, Length=206, Percent_Identity=31.5533980582524, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24655464, Length=187, Percent_Identity=28.8770053475936, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24655467, Length=187, Percent_Identity=28.8770053475936, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2307_MYCTU (Q50658)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   G70734
- RefSeq:   NP_216823.1
- RefSeq:   NP_336836.1
- ProteinModelPortal:   Q50658
- EnsemblBacteria:   EBMYCT00000001656
- EnsemblBacteria:   EBMYCT00000070998
- GeneID:   885277
- GeneID:   924056
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2364
- KEGG:   mtu:Rv2307c
- TIGR:   MT2364
- TubercuList:   Rv2307c
- GeneTree:   EBGT00050000015241
- HOGENOM:   HBG678036
- OMA:   QDDIVPF
- ProtClustDB:   CLSK791768
- InterPro:   IPR002925

Pfam domain/function: PF01738 DLH

EC number: NA

Molecular weight: Translated: 29672; Mature: 29540

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1bd55e28)-; HASH(0x1bd2991c)-; HASH(0x1b1b0524)-; HASH(0x1b200720)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQ
CCHHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEECC
DGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNP
CCCEECCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
GRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPF
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCH
TSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAA
HHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHC
AEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ
CCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQ
CHHHHHCCHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEECC
DGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNP
CCCEECCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
GRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPF
CCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCH
TSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAA
HHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHC
AEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ
CCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036