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The map label for this gene is uvrC [C]

Identifier: 148823398

GI number: 148823398

Start: 2466022

End: 2467959

Strand: Direct

Name: uvrC [C]

Synonym: TBFG_12219

Alternate gene names: 148823398

Gene position: 2466022-2467959 (Clockwise)

Preceding gene: 148823394

Following gene: 148823400

Centisome position: 55.74

GC content: 69.66

Gene sequence:

>1938_bases
GTGCAGGGGCCTAACGTCGCGGCCATGGGTGCAACCGGTGGGACTCAGCTGAGTTTCGCCGACCTGGCACACGCCCAGGG
GGCAGCCTGGACCCCAGCCGACGAGATGTCCCTGCGCGAGACCACCTTCGTCGTGGTCGACCTGGAAACCACAGGTGGGC
GCACGACGGGTAACGACGCAACACCGCCGGACGCGATCACCGAAATCGGGGCGGTCAAGGTATGCGGCGGCGCGGTGCTC
GGTGAATTCGCCACCCTGGTAAACCCGCAACACAGCATTCCGCCCCAGATCGTGCGGCTCACCGGTATCACTACGGCGAT
GGTGGGTAATGCCCCGACGATCGACGCCGTCCTGCCGATGTTCTTCGAGTTCGCCGGCGACTCGGTGCTCGTGGCCCACA
ACGCTGGGTTCGATATCGGATTCCTGCGCGCCGCCGCGAGGCGGTGCGATATCACCTGGCCCCAACCACAGGTGTTGTGC
ACGATGCGGCTGGCCCGGCGGGTGCTGAGCCGAGACGAAGCCCCTAGCGTGCGTCTGGCCGCGCTAGCGCGGCTGTTCGC
CGTCGCCAGCAACCCCACCCACCGCGCCCTCGACGACGCTCGCGCCACCGTCGACGTGCTGCACGCACTCATCGAGCGAG
TGGGCAACCAGGGCGTGCACACCTATGCCGAGCTGCGCTCGTATCTGCCCAACGTGACCCAGGCGCAGCGCTGCAAACGG
GTACTGGCGGAAACACTGCCGCACCGGCCGGGGGTGTACCTGTTCCGCGGACCGTCGGGCGAGGTGCTCTATGTCGGCAC
CGCGGCGGACTTGCGCCGCCGGGTAAGCCAGTACTTCAACGGCACCGACCGCCGCAAGCGGATGACGGAGATGGTCATGC
TGGCCAGCTCGATCGATCATGTCGAATGCGCGCACCCCCTGGAGGCCGGTGTCCGTGAGCTGCGGATGCTGTCGACGCAT
GCCCCGCCGTATAACCGCAGGTCGAAGTTCCCATACCGGTGGTGGTGGGTGGCGCTCACCGATGAAGCATTTCCACGCCT
GTCGGTCATCCGGGCCCCGCGACACGACCGCGTCGTCGGCCCGTTCCGATCCCGCTCCAAGGCCGCCGAGACGGCAGCGC
TGCTGGCACGCTGCACGGGACTGCGAACCTGCACCACTCGGCTGACACGTTCCGCCCGGCACGGACCCGCCTGCCCCGAG
CTGGAAGTGTCGGCCTGCCCGGCCGCCCGCGACGTCACGGCCGCGCAATACGCCGAGGCGGTACTGCGCGCGGCGGCCTT
GATCGGCGGATTGGACAACGCCGCGCTGGCCGCGGCCGTTCAACAGGTCACTGAGCTCGCCGAGCGCCGTCGCTATGAGA
GCGCTGCCCGACTGCGTGACCACCTCGCCACCGCCATCGAGGCGTTGTGGCATGGCCAACGATTGCGAGCACTGGCCGCG
CTGCCCGAGTTGATCGCCGCCAAGCCGGACGGCCCCAGGGAGGGCGGCTACCAACTGGCCGTCATTCGCCACGGCCAACT
CGCCGCTGCCGGCAGGGCACCGCGCGGGGTTCCTCCGATGCCTGTGGTCGACGCCATCCGCCGCGGCGCTCAGGCGATCC
TGCCTACGCCGGCACCGCTCGGCGGGGCACTGGTGGAGGAGATCGCGCTCATCGCCCGCTGGCTGGCCGAGCCGGGAGTG
CGCATCGTCGGGGTCTCGAACGACGCCGCAGGGTTGGCCTCCCCAGTGCGCTCGGCCGGCCCGTGGGCAGCGTGGGCGGC
AACGGCGCGCTCGGCCCAGTTGGCCGGCGAGCAGCTCAGCAGAGGTTGGCAGTCAGATCTGCCGACCGAACCGCACCCAT
CGCGCGAGCAACTGTTCGGCCGCACCGGTGTCGATTGCCGCACTGGCCCGCCGCAACCCCTCCTCCCAGGCCGGCAGCCA
TTCAGCACGGCTGGATAA

Upstream 100 bases:

>100_bases
CCTCTCGGCTTGGCTCATGAGGTCGTCCGAACGCTAATCGCGAGCACCGACATCCGTTGCCGCCGCGTGCGCGCTCGGCG
TAGGGAGCGTTTGCGTGTCA

Downstream 100 bases:

>100_bases
TCCGGCGTGGGCGACGATCGCACCGGCGGCGTTGAGCACCACAGCGTCCCGGACCGGGCCCCTGGCACCGCCCAACACCG
CGCGCACCGCGGCCGCGTTG

Product: hypothetical protein

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVL
GEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLC
TMRLARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKR
VLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTH
APPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPE
LEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAA
LPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGV
RIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQP
FSTAG

Sequences:

>Translated_645_residues
MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVL
GEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLC
TMRLARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKR
VLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTH
APPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPE
LEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAA
LPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGV
RIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQP
FSTAG
>Mature_645_residues
MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDATPPDAITEIGAVKVCGGAVL
GEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPMFFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLC
TMRLARRVLSRDEAPSVRLAALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKR
VLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDHVECAHPLEAGVRELRMLSTH
APPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVGPFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPE
LEVSACPAARDVTAAQYAEAVLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAA
LPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPLGGALVEEIALIARWLAEPGV
RIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLSRGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQP
FSTAG

Specific function: The Uvrabc Repair System Catalyzes The Recognition And Processing Of DNA Lesions. Uvrc Both Incises The 5' And 3' Sides Of The Lesion. The N-Terminal Half Is Responsible For The 3' Incision And The C-Terminal Half Is Responsible For The 5' Incision. [C]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081999, Length=228, Percent_Identity=26.7543859649123, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788149, Length=178, Percent_Identity=31.4606741573034, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2191_MYCTU (Q10384)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   H70783
- RefSeq:   NP_216707.1
- RefSeq:   NP_336719.1
- ProteinModelPortal:   Q10384
- EnsemblBacteria:   EBMYCT00000000128
- EnsemblBacteria:   EBMYCT00000072423
- GeneID:   887265
- GeneID:   924179
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2247
- KEGG:   mtu:Rv2191
- TIGR:   MT2247
- TubercuList:   Rv2191
- GeneTree:   EBGT00050000016419
- HOGENOM:   HBG668323
- OMA:   PYNRRSR
- ProtClustDB:   PRK07883
- GO:   GO:0005829
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305
- SMART:   SM00479
- SMART:   SM00465
- TIGRFAMs:   TIGR00573

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG; SSF53098 RNaseH_fold; SSF82771 UvrC_N

EC number: 2.7.7.7

Molecular weight: Translated: 69181; Mature: 69181

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDA
CCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCHHHCCCCEEEEEEEEEECCCCCCCCCCC
TPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPM
CCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHCHHHHHCCCCCCHHHHHHH
FFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLCTMRLARRVLSRDEAPSVRLA
HHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
ALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
VLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDH
HHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
VECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVG
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHCCCCCCCCCC
PFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPELEVSACPAARDVTAAQYAEA
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPL
HHHHHHCCCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCHHHHHHHCCCCEECCCCCCC
GGALVEEIALIARWLAEPGVRIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLS
CHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQPFSTAG
CCHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQGPNVAAMGATGGTQLSFADLAHAQGAAWTPADEMSLRETTFVVVDLETTGGRTTGNDA
CCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCHHHCCCCEEEEEEEEEECCCCCCCCCCC
TPPDAITEIGAVKVCGGAVLGEFATLVNPQHSIPPQIVRLTGITTAMVGNAPTIDAVLPM
CCCHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHCHHHHHCCCCCCHHHHHHH
FFEFAGDSVLVAHNAGFDIGFLRAAARRCDITWPQPQVLCTMRLARRVLSRDEAPSVRLA
HHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
ALARLFAVASNPTHRALDDARATVDVLHALIERVGNQGVHTYAELRSYLPNVTQAQRCKR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
VLAETLPHRPGVYLFRGPSGEVLYVGTAADLRRRVSQYFNGTDRRKRMTEMVMLASSIDH
HHHHHCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
VECAHPLEAGVRELRMLSTHAPPYNRRSKFPYRWWWVALTDEAFPRLSVIRAPRHDRVVG
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHCCCCCCCCCC
PFRSRSKAAETAALLARCTGLRTCTTRLTRSARHGPACPELEVSACPAARDVTAAQYAEA
CHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VLRAAALIGGLDNAALAAAVQQVTELAERRRYESAARLRDHLATAIEALWHGQRLRALAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPELIAAKPDGPREGGYQLAVIRHGQLAAAGRAPRGVPPMPVVDAIRRGAQAILPTPAPL
HHHHHHCCCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCHHHHHHHCCCCEECCCCCCC
GGALVEEIALIARWLAEPGVRIVGVSNDAAGLASPVRSAGPWAAWAATARSAQLAGEQLS
CHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RGWQSDLPTEPHPSREQLFGRTGVDCRTGPPQPLLPGRQPFSTAG
CCHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036