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The map label for this gene is dtd

Identifier: 148823109

GI number: 148823109

Start: 2152667

End: 2153098

Strand: Reverse

Name: dtd

Synonym: TBFG_11926

Alternate gene names: 148823109

Gene position: 2153098-2152667 (Counterclockwise)

Preceding gene: 148823111

Following gene: 148823108

Centisome position: 48.66

GC content: 66.67

Gene sequence:

>432_bases
GTGCGGGTTCTGGTGCAACGGGTCTCATCGGCTGCGGTGAGGGTCGATGGTCGGGTGGTCGGCGCTATCCGGCCGGACGG
GCAGGGCCTGGTCGCGTTCGTCGGTGTCACCCACGGCGACGATCTCGACAAGGCGCGCCGTCTCGCCGAAAAGCTCTGGA
ATTTGCGGGTTCTCGCCGACGAGAAATCCGCCTCCGACATGCACGCACCGATCCTGGTAATCAGCCAGTTCACCCTCTAC
GCAGACACCGCGAAGGGTCGGCGACCGTCCTGGAACGCCGCGGCGCCAGGTGCGGTGGCGCAGCCCCTGATAGCAGCGTT
CGCGGCAGCGCTGCGCCAGTTGGGAGCGCACGTGGAAGCCGGCGTGTTCGGTGCCCACATGCAGGTCGAACTGGTCAACG
ACGGTCCGGTGACCGTAATGCTGGAAGGCTGA

Upstream 100 bases:

>100_bases
CCACGCCCAGCGGGGTGACGGAAAACGCGACCAGCACAGACACACAATGAGCCTACCCAGCCCCAGCGACTGCATAGCCG
GCCTGGCAGCATCGAGGCTC

Downstream 100 bases:

>100_bases
TGAGATGACTACACCTGAGTATGGCTCGCTTCGTTCCGATGACGACCACTGGGACATTGTCAGCAACGTGGGCTACACCG
CGCTACTGGTTGCGGGTTGG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLADEKSASDMHAPILVISQFTLY
ADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG

Sequences:

>Translated_143_residues
MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLADEKSASDMHAPILVISQFTLY
ADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG
>Mature_143_residues
MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLADEKSASDMHAPILVISQFTLY
ADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEAGVFGAHMQVELVNDGPVTVMLEG

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=150, Percent_Identity=37.3333333333333, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1790320, Length=147, Percent_Identity=41.4965986394558, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=37.7483443708609, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319982, Length=151, Percent_Identity=36.4238410596026, Blast_Score=101, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281361569, Length=150, Percent_Identity=38.6666666666667, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_MYCBO (P63996)

Other databases:

- EMBL:   BX248340
- RefSeq:   NP_855583.1
- ProteinModelPortal:   P63996
- SMR:   P63996
- EnsemblBacteria:   EBMYCT00000015201
- GeneID:   1093186
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1932c
- GeneTree:   EBGT00050000016710
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   MBOV233413:MB1932C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15117; Mature: 15117

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: ACT_SITE 78-78

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLAD
CHHHHHHHHHHEEEECCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCEEEEEC
EKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEA
CCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GVFGAHMQVELVNDGPVTVMLEG
CEEECEEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MRVLVQRVSSAAVRVDGRVVGAIRPDGQGLVAFVGVTHGDDLDKARRLAEKLWNLRVLAD
CHHHHHHHHHHEEEECCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHCEEEEEC
EKSASDMHAPILVISQFTLYADTAKGRRPSWNAAAPGAVAQPLIAAFAAALRQLGAHVEA
CCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GVFGAHMQVELVNDGPVTVMLEG
CEEECEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972