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The map label for this gene is lldD2

Identifier: 148823083

GI number: 148823083

Start: 2130098

End: 2131342

Strand: Reverse

Name: lldD2

Synonym: TBFG_11900

Alternate gene names: 148823083

Gene position: 2131342-2130098 (Counterclockwise)

Preceding gene: 148823091

Following gene: 148823082

Centisome position: 48.17

GC content: 66.27

Gene sequence:

>1245_bases
ATGGCGGTCAACCGGCGAGTGCCCAGAGTGCGCGATCTGGCACCCCTGCTCCAGTTCAACAGGCCGCAGTTCGACACCTC
CAAGCGCCGCCTGGGCGCCGCGCTGACCATCCAGGACCTGCGACGCATTGCCAAACGGCGTACCCCTAGGGCGGCGTTCG
ACTACGCCGACGGGGGTGCCGAGGACGAACTGTCCATCGCGCGTGCTCGACAAGGGTTCCGCGACATCGAGTTTCACCCG
ACAATCCTGCGTGACGTCACCACCGTGTGCGCCGGCTGGAACGTCCTCGGTCAGCCCACCGTCTTGCCATTCGGGATCGC
GCCAACCGGGTTCACCCGCTTGATGCACACCGAGGGCGAGATCGCCGGCGCGCGGGCGGCGGCCGCGGCTGGGATCCCGT
TTTCGCTATCCACCCTGGCCACCTGTGCCATCGAAGACCTCGTCATCGCTGTGCCGCAGGGCCGCAAATGGTTCCAGCTG
TATATGTGGCGTGATCGAGACCGCTCGATGGCATTGGTGCGGCGCGTCGCCGCCGCGGGATTTGACACCATGCTGGTCAC
GGTCGACGTCCCGGTCGCCGGTGCCCGGCTACGCGATGTCCGCAACGGGATGTCCATCCCGCCGGCGCTGACGCTGCGAA
CCGTTCTCGACGCGATGGGACACCCGCGGTGGTGGTTCGACTTGTTGACCACCGAACCGCTGGCCTTCGCTTCACTGGAT
CGCTGGCCTGGCACCGTCGGCGAGTACTTGAACACCGTGTTCGACCCCAGCCTCACCTTCGACGATTTGGCCTGGATCAA
GTCGCAGTGGCCGGGCAAGCTCGTTGTCAAAGGGATCCAAACACTCGACGACGCCCGCGCCGTGGTGGACCGCGGCGTCG
ACGGCATCGTGTTGTCCAATCACGGCGGCCGCCAGCTTGACCGAGCCCCGGTACCCTTCCACCTGTTGCCCCACGTGGCA
CGCGAACTGGGCAAACACACCGAAATCCTGGTGGACACCGGCATCATGTCGGGCGCCGATATCGTCGCGGCGATCGCGTT
GGGGGCACGGTGCACGCTGATCGGGCGGGCCTACCTTTACGGGCTGATGGCCGGTGGTGAGGCGGGCGTCAACCGCGCGA
TCGAGATCCTTCAGACAGGTGTGATCCGGACCATGCGGCTACTGGGCGTGACCTGCCTTGAGGAGCTGTCACCTCGGCAC
GTGACACAACTGCGGCGGCTCGGCCCTATCGGGGCACCAACGTGA

Upstream 100 bases:

>100_bases
CTCGACGACGCTGCGGTAGACCGGAGCCTGCGCGTACACGAAACGCTTCAGGTCGAACGGGTCGCTTGCTGACTTCATAT
CACACTGGTTAGATAAACGG

Downstream 100 bases:

>100_bases
GGCCGCGGCCAGATCGGTAGCGTTGAATGCAGCTATGAATCTCAAGCGGGAATTCGTCCATCGCGTGCAACGGTTCGTGG
TCAATCCAATCGGCCGGCAA

Product: L-lactate dehydrogenase (cytochrome) lldD2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGAEDELSIARARQGFRDIEFHP
TILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQL
YMWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLD
RWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVA
RELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRH
VTQLRRLGPIGAPT

Sequences:

>Translated_414_residues
MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGAEDELSIARARQGFRDIEFHP
TILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQL
YMWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLD
RWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVA
RELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRH
VTQLRRLGPIGAPT
>Mature_413_residues
AVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGAEDELSIARARQGFRDIEFHPT
ILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGEIAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLY
MWRDRDRSMALVRRVAAAGFDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLDR
WPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSNHGGRQLDRAPVPFHLLPHVAR
ELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLYGLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRHV
TQLRRLGPIGAPT

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=33.8935574229692, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=34.2245989304813, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=34.2245989304813, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=37.2654155495979, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI193208036, Length=372, Percent_Identity=34.1397849462366, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=34.2756183745583, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=31.6753926701571, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI78707188, Length=378, Percent_Identity=34.1269841269841, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281363140, Length=378, Percent_Identity=34.1269841269841, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI78707190, Length=378, Percent_Identity=34.1269841269841, Blast_Score=231, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD2_MYCTU (P95143)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   H70667
- RefSeq:   NP_216388.1
- RefSeq:   NP_336378.1
- HSSP:   P05414
- ProteinModelPortal:   P95143
- SMR:   P95143
- EnsemblBacteria:   EBMYCT00000000065
- EnsemblBacteria:   EBMYCT00000070298
- GeneID:   885754
- GeneID:   923667
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1921
- KEGG:   mtu:Rv1872c
- TIGR:   MT1921
- TubercuList:   Rv1872c
- GeneTree:   EBGT00050000016192
- HOGENOM:   HBG517781
- OMA:   WFQLYLW
- ProtClustDB:   CLSK871978
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 45342; Mature: 45211

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 301-301 BINDING 55-55 BINDING 137-137 BINDING 159-159 BINDING 161-161 BINDING 187-187 BINDING 196-196 BINDING 277-277 BINDING 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGA
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHEEHHHHHHHHHHCCCCCCCCCCCCCC
EDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGE
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCC
IAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMWRDRDRSMALVRRVAAAG
HHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCC
FDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLD
CCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHH
RWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSN
CCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLY
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHH
GLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRHVTQLRRLGPIGAPT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGA
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHEEHHHHHHHHHHCCCCCCCCCCCCCC
EDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGE
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCC
IAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMWRDRDRSMALVRRVAAAG
HHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCHHHHHHHHHHHCC
FDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLD
CCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHH
RWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSN
CCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEC
HGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLY
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHH
GLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRHVTQLRRLGPIGAPT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036