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The map label for this gene is erg3 [H]

Identifier: 148823027

GI number: 148823027

Start: 2064731

End: 2065675

Strand: Direct

Name: erg3 [H]

Synonym: TBFG_11844

Alternate gene names: 148823027

Gene position: 2064731-2065675 (Clockwise)

Preceding gene: 148823024

Following gene: 148823028

Centisome position: 46.67

GC content: 61.48

Gene sequence:

>945_bases
GTGGATGCCGTCGCCGGATTCTTCTCAGCGCTGCCCGAGGAAATGCGGGACCCGGTACTGTTCGCCATTCCATGTTTTCT
ATTGCTGCTGATTCTCGAATGGACGGCGGCCCGCAAGCTGGAAAGCATCGAGACCGCTGCTACCGGGCAGCCACGGCCCG
CCTCGGGCGCTTACCTCACCCGCGACTCGGTGGCCAGCATCTCGATGGGGCTGGTTTCGATAGCCACCACCGCCGGCTGG
AAGTCCCTTGCCCTGCTCGGTTATGCCGCAATCTATGCCTACCTTGCCCCCTGGCAGCTGTCCGCCCACCGGTGGTACAC
CTGGGTGATCGCGATCGTTGGTGTCGATCTGCTGTACTACTCCTATCACCGCATCGCCCACCGAGTTCGGCTGATCTGGG
CTACCCACCAGGCGCATCACTCCAGCGAATACTTCAACTTCGCCACCGCGCTGCGCCAGAAGTGGAACAACAGCGGCGAG
ATTCTCATGTGGGTTCCGCTGCCACTGATGGGGCTTCCCCCTTGGATGGTGTTCTGCAGTTGGTCGCTGAACTTGATCTA
CCAGTTCTGGGTGCACACCGAGCGGATCGACAGGCTGCCGCGGTGGTTCGAATTCGTCTTCAATACCCCGTCGCACCACC
GGGTCCACCACGGAATGGACCCGGTGTATCTGGACAAGAACTATGGCGGCATCCTCATCATCTGGGACCGCCTGTTCGGT
AGCTTTCAGCCGGAGCTATTCCGACCGCATTATGGCCTGACCAAGCGGGTCGACACGTTCAACATCTGGAAGCTGCAGAC
CCGCGAGTACGTGGCGATCGTGCGTGACTGGCGGTCGGCAACACGTCTGCGGGATCGGCTGGGCTACGTCTTCGGACCGC
CGGGCTGGGAACCGCGCACCATCGATAAATCCAATGCCGCCGCCTCCCTGGTCACGTCTCGGTAA

Upstream 100 bases:

>100_bases
CTCTAACAGCACCGACCGGATAGGGAACAACGGCCTTCGGGCAAGCGGCTTCACTGTCAAGTCGTCACCTGTCACGCATG
CGAGTCGTAGCCTGTCTGAT

Downstream 100 bases:

>100_bases
CGTCGCGACCCGACATTGCGAAAGTATTACCGTCGGGTTTTGGTACGCCTTAGCCGTAACCGGCGGCGGGCGATGCGCTT
GGCCCCGACGGATGGGAGTT

Product: membrane-bound C-5 sterol desaturase erg3 (sterol-c5-desaturase)

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MDAVAGFFSALPEEMRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGW
KSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGE
ILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFG
SFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR

Sequences:

>Translated_314_residues
MDAVAGFFSALPEEMRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGW
KSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGE
ILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFG
SFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR
>Mature_314_residues
MDAVAGFFSALPEEMRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLTRDSVASISMGLVSIATTAGW
KSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGE
ILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFG
SFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRTIDKSNAAASLVTSR

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=287, Percent_Identity=37.9790940766551, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25144659, Length=249, Percent_Identity=33.7349397590361, Blast_Score=147, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 36348; Mature: 36348

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVAGFFSALPEEMRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLT
CCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
RDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCS
HHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
WSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCEEEEHHHHCC
SFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRT
CCCCHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
IDKSNAAASLVTSR
CCCCCCHHHHHCCC
>Mature Secondary Structure
MDAVAGFFSALPEEMRDPVLFAIPCFLLLLILEWTAARKLESIETAATGQPRPASGAYLT
CCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
RDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYY
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SYHRIAHRVRLIWATHQAHHSSEYFNFATALRQKWNNSGEILMWVPLPLMGLPPWMVFCS
HHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
WSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCCCEEEEHHHHCC
SFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFGPPGWEPRT
CCCCHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCC
IDKSNAAASLVTSR
CCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]