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The map label for this gene is trpC [H]

Identifier: 148822818

GI number: 148822818

Start: 1805601

End: 1806449

Strand: Direct

Name: trpC [H]

Synonym: TBFG_11627

Alternate gene names: 148822818

Gene position: 1805601-1806449 (Clockwise)

Preceding gene: 148822817

Following gene: 148822819

Centisome position: 40.81

GC content: 66.43

Gene sequence:

>849_bases
GTGGGTGACAGTGGGAAGGGAACGGCAGGCATGAGTCCGGCAACCGTGCTCGACTCCATCCTCGAGGGAGTCCGGGCCGA
CGTTGCCGCGCGTGAAGCCTCGGTGAGCCTGTCGGAGATCAAGGCTGCCGCCGCTGCGGCGCCGCCGCCGCTCGACGTGA
TGGCCGCCCTACGCGAGCCCGGCATCGGCGTCATCGCTGAGGTCAAGCGCGCTAGTCCTTCGGCAGGCGCATTGGCGACC
ATCGCCGACCCGGCAAAGCTGGCCCAGGCCTACCAGGATGGCGGTGCCCGGATCGTCAGCGTGGTGACTGAGCAGCGGCG
TTTTCAGGGATCGCTCGACGACCTCGACGCGGTGCGGGCCTCGGTTTCGATTCCGGTGCTGCGCAAGGACTTTGTGGTGC
AGCCGTACCAGATTCATGAGGCGCGTGCGCACGGCGCCGACATGTTGTTGCTCATCGTCGCCGCATTGGAGCAGTCGGTG
TTGGTGTCGATGTTGGACCGCACCGAATCGTTGGGTATGACAGCACTCGTCGAGGTCCATACCGAGCGGGAAGCCGACCG
AGCGCTGAAGGCCGGGGCCAAGGTGATTGGCGTTAACGCCCGCGACCTCATGACGCTGGACGTGGACCGGGATTGCTTCG
CGCGAATAGCTCCTGGTTTGCCGAGCAGTGTGATCAGGATTGCTGAATCCGGCGTGCGTGGCACCGCTGACCTGCTGGCG
TACGCCGGCGCGGGCGCTGACGCGGTGTTGGTAGGCGAAGGTCTGGTCACCAGCGGCGACCCACGTGCCGCGGTTGCCGA
TCTGGTTACCGCGGGCACCCATCCGTCCTGTCCGAAACCGGCTCGCTAG

Upstream 100 bases:

>100_bases
CGACCGATCGGGAGCAGGAGTCTGACACCGAGGGGCGGTGACGGACCGCGCGCTGACGGTCGCTACCCTTCATGGACGTC
GTCGAAATTGACGAGCGCGT

Downstream 100 bases:

>100_bases
CCGTCGATGAGCCGCTTGCATCTTGAGCCTCGGTGATGACAGATCTATCCACCCCGGATCTTCCGCGCATGAGTGCTGCC
ATCGCCGAACCGACCAGTCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MGDSGKGTAGMSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALAT
IADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSV
LVSMLDRTESLGMTALVEVHTEREADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLA
YAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR

Sequences:

>Translated_282_residues
MGDSGKGTAGMSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALAT
IADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSV
LVSMLDRTESLGMTALVEVHTEREADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLA
YAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
>Mature_281_residues
GDSGKGTAGMSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATI
ADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVL
VSMLDRTESLGMTALVEVHTEREADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAY
AGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=35.0597609561753, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=232, Percent_Identity=40.5172413793103, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28913; Mature: 28782

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSGKGTAGMSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCC
GIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRA
CCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHH
SVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVH
HCCCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEH
TEREADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLA
HHHHHHHHHHCCCEEEECCCHHEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
YAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
HCCCCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
GDSGKGTAGMSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCC
GIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRA
CCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHH
SVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVH
HCCCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEH
TEREADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLA
HHHHHHHHHHCCCEEEECCCHHEEEEECCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
YAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
HCCCCCCEEEECCCCEECCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA