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The map label for this gene is wecA

Identifier: 148822520

GI number: 148822520

Start: 1462062

End: 1463276

Strand: Direct

Name: wecA

Synonym: TBFG_11329

Alternate gene names: 148822520

Gene position: 1462062-1463276 (Clockwise)

Preceding gene: 148822519

Following gene: 148822521

Centisome position: 33.05

GC content: 65.1

Gene sequence:

>1215_bases
GTGCAGTACGGTCTCGAGGTGTCCAGCGATGTGGCCGGCGTTGCCGGTGGCTTGCTCGCCCTGTCCTATCGCGGCGCCGG
TGTCCCGCTGCGTGAGCTTGCGCTGGTCGGGCTGACCGCGGCGATCATCACCTATTTTGCGACCGGTCCGGTGCGGATGC
TGGCCAGTCGCCTGGGAGCCGTCGCCTACCCGCGGGAGCGAGATGTGCACGTCACGCCTACCCCTCGGATGGGTGGGTTG
GCGATGTTCCTGGGCATTGTCGGCGCCGTCTTTCTTGCCTCCCAGCTTCCGGCACTCACCCGGGGGTTCGTCTATTCCAC
CGGCATGCCCGCGGTGCTGGTGGCCGGTGCGGTGATCATGGGCATCGGCCTGATCGATGATCGTTGGGGTCTGGATGCAC
TGACGAAGTTCGCCGGCCAGATCACGGCGGCGAGCGTTCTGGTCACCATGGGTGTCGCCTGGAGTGTCCTGTACATCCCG
GTGGGTGGTGTGGGCACCATCGTCTTGGACCAGGCTTCCTCGATCCTGCTTACCCTGGCGCTGACCGTTTCGATCGTCAA
CGCGATGAACTTTGTCGACGGTCTCGACGGGCTGGCCGCCGGCCTGGGCCTGATAACGGCGCTGGCAATCTGCATGTTCT
CGGTGGGTTTGCTTCGTGACCACGGTGGTGACGTTTTGTACTACCCGCCGGCGGTGATTTCGGTGGTCCTGGCCGGGGCC
TGCCTGGGCTTTCTGCCACACAACTTCCACCGGGCCAAGATCTTCATGGGCGATTCCGGGTCGATGCTGATCGGCCTGAT
GCTGGCCGCCGCTTCCACCACCGCGGCCGGGCCGATCTCGCAGAACGCCTACGGCGCTCGTGATGTATTTGCTTTGCTGT
CGCCGTTCCTGCTGGTGGTGGCGGTCATGTTTGTGCCAATGCTCGACCTGCTGCTAGCGATCGTCCGTCGCACCCGCGCC
GGCCGCAGCGCGTTTAGCCCGGACAAAATGCACCTGCATCACCGGCTGCTGCAGATCGGTCATTCCCATCGGCGCGTGGT
CCTGATCATCTACCTGTGGGTGGGCATCGTTGCCTTCGGCGCCGCGAGCTCGATCTTCTTTAACCCGCGCGACACCGCGG
CGGTGATGCTGGGCGCGATCGTGGTCGCCGGCGTCGCGACACTGATCCCCCTGTTGCGCCGCGGCGACGACTACTACGAC
CCGGACCTGGACTAG

Upstream 100 bases:

>100_bases
CCAGCTTGTTCGGCTAGCCGCCGAACGTGCACGCACTGCGAAGATTCGGCCAATTGTTCGCAGCTGTTGCACGTTCGGCG
AGTGTTCAGCTCTCAGGTTG

Downstream 100 bases:

>100_bases
CCCGGAGCCGAGAACTACGACAAGGAGTAGTAGTGGTGTCTACCTTGTGGTACGGTGCGGCTAGAACCCCGAAGGAGACC
TCGCGGGTTGCCGGCCCCCG

Product: undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase rfe

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGL
AMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIP
VGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGA
CLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRA
GRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYD
PDLD

Sequences:

>Translated_404_residues
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGL
AMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIP
VGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGA
CLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRA
GRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYD
PDLD
>Mature_404_residues
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGL
AMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIP
VGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGA
CLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRA
GRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYD
PDLD

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily

Homologues:

Organism=Escherichia coli, GI1790218, Length=313, Percent_Identity=29.073482428115, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECA_MYCTU (Q10606)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   B70774
- RefSeq:   NP_215818.1
- RefSeq:   NP_335789.1
- EnsemblBacteria:   EBMYCT00000000921
- EnsemblBacteria:   EBMYCT00000070363
- GeneID:   886947
- GeneID:   924729
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1341
- KEGG:   mtu:Rv1302
- TIGR:   MT1341
- TubercuList:   Rv1302
- GeneTree:   EBGT00050000016928
- HOGENOM:   HBG708263
- OMA:   LWIISIT
- ProtClustDB:   CLSK791089
- BioCyc:   MetaCyc:MONOMER-15252
- InterPro:   IPR000715
- PANTHER:   PTHR22926

Pfam domain/function: PF00953 Glycos_transf_4

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42258; Mature: 42258

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x40da04e0)-; HASH(0x1a18acd8)-; HASH(0x1a13773c)-; HASH(0x1a197330)-; HASH(0x1a4b689c)-; HASH(0x19820644)-; HASH(0x40d8dd54)-; HASH(0x1a3518f4)-; HASH(0x19bfefe4)-; HASH(0x19e432c8)-; HASH(0x19eaf3c0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGA
CCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
VAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIM
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCHHCCCCHHHHHHHHHHH
GIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGGVGTIVLDQASSILLTLA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHH
LTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
CLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVV
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
AASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYDPDLD
CHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGA
CCCCCCCCCCHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
VAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIM
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCHHCCCCHHHHHHHHHHH
GIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGGVGTIVLDQASSILLTLA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHHHHH
LTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
CLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVV
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
AASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYDPDLD
CHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036