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The map label for this gene is 148822476

Identifier: 148822476

GI number: 148822476

Start: 1409848

End: 1411107

Strand: Reverse

Name: 148822476

Synonym: TBFG_11284

Alternate gene names: NA

Gene position: 1411107-1409848 (Counterclockwise)

Preceding gene: 148822478

Following gene: 148822474

Centisome position: 31.89

GC content: 67.14

Gene sequence:

>1260_bases
ATGAGAAACAGCAACCGCGGCCCGGCATTCCTGATCCTGTTCGCAACGCTGATGGCGGCCGCGGGTGATGGCGTCTCGAT
AGTCGCGTTTCCGTGGCTGGTGTTGCAGCGCGAGGGCAGCGCTGGGCAGGCCTCGATCGTGGCCAGTGCGACCATGCTGC
CGCTGTTGTTCGCCACGCTGGTCGCCGGCACCGCGGTCGACTACTTCGGGCGTCGCCGGGTGTCGATGGTGGCCGATGCG
CTGTCGGGTGCGGCGGTGGCCGGCGTCCCCCTGGTGGCGTGGGGGTACGGCGGCGACGCGGTCAACGTGCTGGTGCTGGC
CGTATTGGCCGCCCTGGCGGCCGCCTTCGGCCCGGCAGGCATGACGGCTCGTGACTCGATGCTGCCCGAGGCCGCCGCTC
GGGCAGGCTGGTCGTTGGACCGCATCAACGGCGCCTACGAGGCGATCCTCAACCTGGCCTTTATTGTCGGCCCGGCCATC
GGTGGCTTGATGATCGCGACGGTTGGCGGCATCACCACAATGTGGATTACCGCGACGGCATTCGGGTTGTCCATCCTCGC
GATTGCCGCCCTGCAACTCGAGGGTGCCGGCAAGCCGCACCACACCTCGCGGCCCCAAGGGTTGGTATCCGGGATCGCCG
AGGGGCTGCGCTTCGTCTGGAACCTGCGGGTATTGCGCACCCTCGGGATGATTGACCTGACCGTCACCGCGCTGTATCTG
CCGATGGAGAGCGTGCTGTTCCCGAAATACTTCACCGACCACCAGCAACCGGTGCAGCTGGGTTGGGCGTTGATGGCGAT
CGCCGGCGGCGGCCTGGTGGGAGCGCTGGGGTATGCCGTGTTGGCTATCCGCGTTCCCCGTCGCGTGACCATGTCGACCG
CGGTTCTTACCCTGGGTTTGGCATCGATGGTCATCGCGTTCCTGCCGCCACTGCCGGTCATCATGGTGTTGTGCGCGGTG
GTCGGCCTGGTGTACGGACCCATCCAGCCGATCTATAACTACGTGATACAGACGCGGGCAGCACAGCATCTGCGCGGCCG
GGTAGTCGGGGTGATGACGTCGCTGGCCTACGCCGCCGGCCCGTTGGGTCTGTTGCTGGCCGGTCCACTGACCGACGCCG
CTGGACTGCATGCCACGTTTCTCGCGTTGGCACTGCCCATCGTGTGCACCGGGCTGGTCGCGATCCGGCTGCCCGCGCTG
CGCGAACTGGATCTGGCGCCCCAAGCGGACATCGATCGGCCCGTAGGATCGGCTCAGTGA

Upstream 100 bases:

>100_bases
CGGATGCATGAGCACACGAACATCCTGCATCCGGGCTGCGGCAGCGCAGAAATTCGGTGGCCCCCATACCGGTTTGGCGC
TAGATTCAGCCGCGATATTC

Downstream 100 bases:

>100_bases
ATACCGATGTGCTGGCTGGCCTGATGGCCGAGCTGCCCGAGGGGATGGTGGTCACCGACCCCGCCGTCACCGACGGCTAC
CGGCAAGACCGGGCCTTTGA

Product: integral membrane transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADA
LSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAI
GGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYL
PMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAV
VGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPAL
RELDLAPQADIDRPVGSAQ

Sequences:

>Translated_419_residues
MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADA
LSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAI
GGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYL
PMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAV
VGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPAL
RELDLAPQADIDRPVGSAQ
>Mature_419_residues
MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADA
LSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAI
GGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYL
PMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAV
VGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPAL
RELDLAPQADIDRPVGSAQ

Specific function: Could be involved in tetracycline efflux

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1258_MYCTU (P64783)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   B70753
- RefSeq:   NP_215774.1
- RefSeq:   NP_335741.1
- ProteinModelPortal:   P64783
- EnsemblBacteria:   EBMYCT00000001737
- EnsemblBacteria:   EBMYCT00000069056
- GeneID:   887056
- GeneID:   924773
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1297
- KEGG:   mtu:Rv1258c
- TIGR:   MT1297
- TubercuList:   Rv1258c
- GeneTree:   EBGT00050000014794
- HOGENOM:   HBG565477
- OMA:   HANSVFE
- ProtClustDB:   CLSK871916
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 43288; Mature: 43288

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a119e18)-; HASH(0x1a4a2a68)-; HASH(0x18c7f548)-; HASH(0x1a03160c)-; HASH(0x19eaa2d4)-; HASH(0x18639268)-; HASH(0x19e71e58)-; HASH(0x197fcd7c)-; HASH(0x170d30b8)-; HASH(0x1a140cd4)-; HASH(0x1a1a4398)-; HASH(0x19811770)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATL
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
VAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAG
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
MTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATA
CCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGL
HHHHHHCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAG
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
CHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATL
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
VAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAG
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCC
MTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATA
CCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGL
HHHHHHCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAG
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
CHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036