| Definition | Mycobacterium tuberculosis H37Ra, complete genome. |
|---|---|
| Accession | NC_009525 |
| Length | 4,419,977 |
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The map label for this gene is dacB [H]
Identifier: 148663490
GI number: 148663490
Start: 4074347
End: 4075732
Strand: Reverse
Name: dacB [H]
Synonym: MRA_3663
Alternate gene names: 148663490
Gene position: 4075732-4074347 (Counterclockwise)
Preceding gene: 148663492
Following gene: 148663489
Centisome position: 92.21
GC content: 68.47
Gene sequence:
>1386_bases ATGGGTCCCACACGCTGGCGGAAATCCACGCACGTGGTCGTCGGCGCGGCCGTGCTGGCGTTTGTCGCCGTTGTGGTGGC GGCCGCAGCGCTGGTCACTACTGGTGGTCACCGGGCTGGCGTGCGCGCACCTGCGCCTCCACCGCGGCCACCCACAGTCA AGGCGGGAGTGGTCCCTGTGGCGGACACCGCTGCGACACCGAGTGCCGCTGGCGTGACCGCGGCGCTTGCGGTGGTGGCG GCCGATCCTGATCTGGGCAAGTTAGCAGGTCGGATCACCGATGCCCTGACCGGACAAGAACTTTGGCAGCGGCTAGACGA CGTGCCCTTGGTGCCGGCTTCGACCAACAAAATCCTGACGGCGGCGGCGGCTCTGCTGACACTGGACCGACAGGCCCGGA TCAGCACGCGGGTGGTGGCCGGCGGCCAGAACCCCCAGGGACCTGTCGTGTTGGTGGGCGCGGGCGATCCGACGCTGTCG GCAGCGCCGCCCGGTCAGGACACCTGGTATCACGGCGCGGCTCGCATCGGTGACCTCGTCGAACAAATTCGCCGCAGCGG TGTGACGCCCACCGCCGTGCAGGTGGACGCTTCGGCGTTTAGCGGTCCGACGATGGCGCCGGGTTGGGATCCGGCCGATA TCGACAACGGTGACATCGCGCCGATCGAAGCGGCGATGATCGACGCCGGGCGTATCCAGCCGACCACCGTCAATTCGAGA CGGTCCCGCACCCCGGCGCTGGATGCCGGTCGGGAGTTGGCCAAAGCCCTTGGCCTGGACCCCGCGGCGGTGACGATCGC ATCGGCTCCGGCCGGCGCGCGGCAGCTGGCCGTGGTGCAGTCGGCGCCGTTGATCCAGCGACTGTCTCAGATGATGAACG CCTCCGACAATGTGATGGCCGAGTGCATCGGCCGCGAGGTAGCGGTCGCGATCAACCGGCCGCAGAGCTTTAGTGGCGCG GTCGACGCGGTGACCAGCCGATTGAACACCGCACACATCGACACCGCCGGCGCTGCGCTGGTGGATTCTAGTGGATTGTC GCTCGACAACCGCCTGACCGCTCGGACGCTCGATGCAACGATGCAGGCCGCGGCTGGACCCGACCAGCCCGCGTTGCGGC CGCTGCTGGATCTGCTACCGATCGCCGGTGGCAGTGGCACGCTGGGCGAGCGCTTCCTCGACGCGGCCACCGACCAGGGT CCGGCCGGGTGGTTGCGGGCCAAGACCGGCTCGCTGACCGCGATCAACTCGCTAGTCGGGGTGCTCACCGACCGTAGCGG CCGAGTGCTCACCTTCGCGTTCATCTCCAACGAAGCCGGTCCCAACGGTCGCAACGCGATGGACGCTCTGGCCACTAAGT TGTGGTTCTGCGGGTGCACGACGTGA
Upstream 100 bases:
>100_bases GGCAGGTCCAATGCGTCCGTGGACACCCTAGTCGAGCCGGTACCGTGGCAGCGTCGCCCGGCCGGTTCGGCAGAATGGGA CCGGAAAGGCAGGAGAGCTC
Downstream 100 bases:
>100_bases CCGGAGCGTCCGAGCTGACACTGGGGAACACGGTCGATTGGGAATTTGCGGCCAGCGTCGGGGAGCGGCTGGCCCGGCCC GCTCCGCCGTCCACCGAATA
Product: D-alanyl-D-alanine carboxypeptidase
Products: NA
Alternate protein names: DD-carboxypeptidase; DD-peptidase; D-alanyl-D-alanine endopeptidase; DD-endopeptidase; Penicillin-binding protein 4; PBP-4 [H]
Number of amino acids: Translated: 461; Mature: 460
Protein sequence:
>461_residues MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVA ADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLS AAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSR RSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGA VDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQG PAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT
Sequences:
>Translated_461_residues MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVA ADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLS AAPPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSR RSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGA VDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQG PAGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT >Mature_460_residues GPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPVADTAATPSAAGVTAALAVVAA DPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILTAAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSA APPGQDTWYHGAARIGDLVEQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSRR SRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMAECIGREVAVAINRPQSFSGAV DAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDATMQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGP AGWLRAKTGSLTAINSLVGVLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT
Specific function: Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction [H]
COG id: COG2027
COG function: function code M; D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)
Gene ontology:
Cell location: Periplasm (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase S13 family [H]
Homologues:
Organism=Escherichia coli, GI1789573, Length=156, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR000667 [H]
Pfam domain/function: PF02113 Peptidase_S13 [H]
EC number: =3.4.16.4 [H]
Molecular weight: Translated: 46835; Mature: 46704
Theoretical pI: Translated: 7.52; Mature: 7.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPV CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEC ADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILT CCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH AAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLV HHHHHHHHCHHHHHEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH EQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSR HHHHHCCCCCCEEEEECHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC RSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMA CCCCCCHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHH ECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDAT HHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHH MQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVG HHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH VLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT HHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC >Mature Secondary Structure GPTRWRKSTHVVVGAAVLAFVAVVVAAAALVTTGGHRAGVRAPAPPPRPPTVKAGVVPV CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEC ADTAATPSAAGVTAALAVVAADPDLGKLAGRITDALTGQELWQRLDDVPLVPASTNKILT CCCCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH AAAALLTLDRQARISTRVVAGGQNPQGPVVLVGAGDPTLSAAPPGQDTWYHGAARIGDLV HHHHHHHHCHHHHHEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH EQIRRSGVTPTAVQVDASAFSGPTMAPGWDPADIDNGDIAPIEAAMIDAGRIQPTTVNSR HHHHHCCCCCCEEEEECHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC RSRTPALDAGRELAKALGLDPAAVTIASAPAGARQLAVVQSAPLIQRLSQMMNASDNVMA CCCCCCHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHHH ECIGREVAVAINRPQSFSGAVDAVTSRLNTAHIDTAGAALVDSSGLSLDNRLTARTLDAT HHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCHHHHHHHHH MQAAAGPDQPALRPLLDLLPIAGGSGTLGERFLDAATDQGPAGWLRAKTGSLTAINSLVG HHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHH VLTDRSGRVLTFAFISNEAGPNGRNAMDALATKLWFCGCTT HHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2040429; 9278503; 2046551 [H]