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The map label for this gene is arsB1 [C]

Identifier: 148662526

GI number: 148662526

Start: 3013951

End: 3015237

Strand: Direct

Name: arsB1 [C]

Synonym: MRA_2713

Alternate gene names: 148662526

Gene position: 3013951-3015237 (Clockwise)

Preceding gene: 148662525

Following gene: 148662532

Centisome position: 68.19

GC content: 64.1

Gene sequence:

>1287_bases
ATGAGCATCATCGCCATCACGGTGTTCGTAGCCGGCTATGCACTTATCGCAAGCGACCGAGTCAGCAAGACCCGGGTGGC
ACTGACGTGCGCGGCGATCATGGTCGGCGCCGGGATCGTCGGATCGGACGACGTGTTCTACTCGCACGAAGCCGGAATCG
ATTGGGACGTCATCTTTCTGCTCTTGGGCATGATGATCATCGTCAGCGTGCTTCGGCACACCGGCGTCTTCGAATACGTC
GCGATTTGGGCCGTCAAACGCGCAAACGCCGCGCCGTTGCGCATCATGATCCTGCTGGTGCTGGTGACCGCGCTGGGGTC
GGCCCTGCTGGACAACGTCACCACGGTGTTGTTGATCGCGCCGGTGACGCTACTGGTATGTGATCGACTGGGGGTCAATT
CCACGCCGTTTTTGGTGGCCGAAGTCTTCGCGTCCAATGTCGGCGGCGCGGCCACGCTGGTCGGCGACCCGCCGAACATC
ATCATCGCCAGCCGGGCGGGACTGACGTTCAACGACTTCCTGATCCACATGGCCCCGGCCGTGCTCGTCGTCATGATCGC
CCTGATCGGTCTGCTGCCCTGGCTGCTGGGCTCCGTCACTGCCGAGCCCGACCGAGTTGCCGACGTGCTGTCGCTCAACG
AGCGCGAAGCCATCCACGATCGCGGGCTGCTCATCAAGTGCGGTGTCGTCTTGGTGCTGGTGTTTGCGGCCTTCATCGCT
CATCCGGTGCTGCACATCCAGCCGTCTCTGGTGGCGCTGCTGGGCGCCGGTGTGCTCGTACGGTTCTCGGGGCTGGAGCG
ATCCGACTACCTGTCCAGCGTCGAGTGGGACACCCTGCTGTTCTTCGCCGGGCTGTTCGTCATGGTGGGGGCCCTGGTGA
AGACCGGTGTCGTCGAGCAACTGGCGCGGGCAGCAACCGAGCTGACCGGCGGCAACGAGTTACTCACAGTCGGTTTGATT
CTCGGCATCTCGGCACCGGTGTCCGGCATCATCGACAACATCCCCTACGTCGCCACGATGACGCCCATCGTGACCGAACT
GGTCGCCGCGATGCCGGGCCACGTCCACCCCGACACGTTCTGGTGGGCACTGGCGCTAAGCGCCGACTTCGGCGGCAACC
TGACCGCCGTGGCAGCCAGCGCCAATGTCGTCATGCTCGGAATCGCCCGGCGCTCGGGCACTCCCATCTCGTTCTGGAAG
TTCACCCGCAAGGGCGCGGTGGTGACCGCGGTCTCGCTCGTGTTGTCGGCGGTCTACCTGTGGCTGCGGTACTTCGTGTT
CGGCTAA

Upstream 100 bases:

>100_bases
TACTTCGTGTTGTTGCACTGACCATCTGTATTGCCGACAGACCTGTAGCACCAGACGACGCCGCGATGAGCGGCCTACGA
GAAGATTCGGAGGATGGCCG

Downstream 100 bases:

>100_bases
GCGCCAACGCTCACGCGTGCTTAGCGCGAAAGCGCCGAAACAGCACCCAGACGATGGCCAGGTTGTAGACGGCACCCCCG
ACGAGATACGGCCACCAGGT

Product: putative arsenic-transport integral membrane protein ArsB1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDDVFYSHEAGIDWDVIFLLLGMMIIVSVLRHTGVFEYV
AIWAVKRANAAPLRIMILLVLVTALGSALLDNVTTVLLIAPVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNI
IIASRAGLTFNDFLIHMAPAVLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAIHDRGLLIKCGVVLVLVFAAFIA
HPVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEWDTLLFFAGLFVMVGALVKTGVVEQLARAATELTGGNELLTVGLI
LGISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTFWWALALSADFGGNLTAVAASANVVMLGIARRSGTPISFWK
FTRKGAVVTAVSLVLSAVYLWLRYFVFG

Sequences:

>Translated_428_residues
MSIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDDVFYSHEAGIDWDVIFLLLGMMIIVSVLRHTGVFEYV
AIWAVKRANAAPLRIMILLVLVTALGSALLDNVTTVLLIAPVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNI
IIASRAGLTFNDFLIHMAPAVLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAIHDRGLLIKCGVVLVLVFAAFIA
HPVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEWDTLLFFAGLFVMVGALVKTGVVEQLARAATELTGGNELLTVGLI
LGISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTFWWALALSADFGGNLTAVAASANVVMLGIARRSGTPISFWK
FTRKGAVVTAVSLVLSAVYLWLRYFVFG
>Mature_427_residues
SIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDDVFYSHEAGIDWDVIFLLLGMMIIVSVLRHTGVFEYVA
IWAVKRANAAPLRIMILLVLVTALGSALLDNVTTVLLIAPVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNII
IASRAGLTFNDFLIHMAPAVLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAIHDRGLLIKCGVVLVLVFAAFIAH
PVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEWDTLLFFAGLFVMVGALVKTGVVEQLARAATELTGGNELLTVGLIL
GISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTFWWALALSADFGGNLTAVAASANVVMLGIARRSGTPISFWKF
TRKGAVVTAVSLVLSAVYLWLRYFVFG

Specific function: Unknown

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family

Homologues:

Organism=Homo sapiens, GI157266326, Length=215, Percent_Identity=37.2093023255814, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1787039, Length=132, Percent_Identity=31.8181818181818, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550608, Length=486, Percent_Identity=30.6584362139918, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI85724998, Length=470, Percent_Identity=25.531914893617, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574683, Length=191, Percent_Identity=40.8376963350785, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574681, Length=191, Percent_Identity=40.8376963350785, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574685, Length=191, Percent_Identity=40.8376963350785, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574678, Length=191, Percent_Identity=40.8376963350785, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI62484377, Length=470, Percent_Identity=25.1063829787234, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24581759, Length=191, Percent_Identity=40.8376963350785, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19920704, Length=191, Percent_Identity=40.8376963350785, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24656008, Length=478, Percent_Identity=24.6861924686192, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221472711, Length=227, Percent_Identity=29.0748898678414, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24581764, Length=227, Percent_Identity=29.0748898678414, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2685_MYCTU (O07187)

Other databases:

- EMBL:   BX842580
- EMBL:   AE000516
- PIR:   H70528
- RefSeq:   NP_337260.1
- RefSeq:   YP_177899.1
- ProteinModelPortal:   O07187
- EnsemblBacteria:   EBMYCT00000003088
- EnsemblBacteria:   EBMYCT00000069827
- GeneID:   888150
- GeneID:   925539
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2759
- KEGG:   mtu:Rv2685
- TIGR:   MT2759
- TubercuList:   Rv2685
- GeneTree:   EBGT00050000016378
- HOGENOM:   HBG727257
- OMA:   NKLKTTP
- ProtClustDB:   CLSK792003
- InterPro:   IPR000802
- InterPro:   IPR004680
- PRINTS:   PR00758

Pfam domain/function: PF03600 CitMHS

EC number: NA

Molecular weight: Translated: 45238; Mature: 45107

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20ac371c)-; HASH(0x2046670c)-; HASH(0x20582eb8)-; HASH(0x20582bac)-; HASH(0x20888358)-; HASH(0x209e2238)-; HASH(0x20473a54)-; HASH(0x209e18b4)-; HASH(0x20a00f78)-; HASH(0x20897850)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDDVFYSHEAGIDWDVIFL
CCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHH
LLGMMIIVSVLRHTGVFEYVAIWAVKRANAAPLRIMILLVLVTALGSALLDNVTTVLLIA
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNIIIASRAGLTFNDFLIHMAPA
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHH
VLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAIHDRGLLIKCGVVLVLVFAAFIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
HPVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEWDTLLFFAGLFVMVGALVKTGVVEQ
CCHHHCCHHHHHHHCCCHHEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LARAATELTGGNELLTVGLILGISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTF
HHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
WWALALSADFGGNLTAVAASANVVMLGIARRSGTPISFWKFTRKGAVVTAVSLVLSAVYL
EEEEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
WLRYFVFG
HHHHHHCH
>Mature Secondary Structure 
SIIAITVFVAGYALIASDRVSKTRVALTCAAIMVGAGIVGSDDVFYSHEAGIDWDVIFL
CEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHH
LLGMMIIVSVLRHTGVFEYVAIWAVKRANAAPLRIMILLVLVTALGSALLDNVTTVLLIA
HHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVTLLVCDRLGVNSTPFLVAEVFASNVGGAATLVGDPPNIIIASRAGLTFNDFLIHMAPA
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHH
VLVVMIALIGLLPWLLGSVTAEPDRVADVLSLNEREAIHDRGLLIKCGVVLVLVFAAFIA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
HPVLHIQPSLVALLGAGVLVRFSGLERSDYLSSVEWDTLLFFAGLFVMVGALVKTGVVEQ
CCHHHCCHHHHHHHCCCHHEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LARAATELTGGNELLTVGLILGISAPVSGIIDNIPYVATMTPIVTELVAAMPGHVHPDTF
HHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
WWALALSADFGGNLTAVAASANVVMLGIARRSGTPISFWKFTRKGAVVTAVSLVLSAVYL
EEEEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHH
WLRYFVFG
HHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036