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The map label for this gene is gnd1 [H]

Identifier: 148661650

GI number: 148661650

Start: 2103663

End: 2105120

Strand: Reverse

Name: gnd1 [H]

Synonym: MRA_1855

Alternate gene names: 148661650

Gene position: 2105120-2103663 (Counterclockwise)

Preceding gene: 148661651

Following gene: 148661649

Centisome position: 47.63

GC content: 65.23

Gene sequence:

>1458_bases
ATGAGTTCGTCGGAATCGCCAGCCGGCATCGCGCAGATCGGCGTCACTGGCCTGGCCGTGATGGGTTCCAACATCGCCCG
AAACTTCGCCCGGCACGGCTACACCGTGGCAGTGCACAATCGGTCGGTCGCCAAGACCGACGCGCTGCTTAAGGAGCACA
GCTCAGACGGCAAGTTCGTGCGCAGTGAAACGATCCCCGAATTTCTTGCCGCACTGGAAAAACCGCGTCGGGTGCTGATC
ATGGTCAAGGCCGGAGAGGCCACTGACGCTGACGCTGTCATCAACGAACTTGCTGACGCCATGGAACCCGGCGACATCAT
CATCGACGGCGGCAATGCGTTGTACACCGACACCATGCGCCGCGAGAAAGCGATGCGTGAGCGGGGCTTGCACTTCGTCG
GGGCCGGGATCTCCGGCGGCGAAGAGGGCGCGTTGAACGGGCCGTCGATCATGCCCGGCGGACCCGCCGAGTCATACCAA
TCGCTGGGTCCGCTGCTCGAGGAGATCTCCGCGCATGTCGACGGCGTGCCGTGCTGCACCCACATTGGCCCGGACGGCTC
CGGGCACTTCGTCAAGATGGTCCACAACGGCATCGAGTACTCCGACATGCAGCTCATCGGTGAGGCCTACCAGCTGATGC
GCGACGGGCTAGGTCTGACCGCGCCGGCGATCGCCGATGTGTTCACCGAGTGGAACAATGGCGATCTGGACAGCTACCTG
GTCGAGATCACCGCCGAGGTGCTGCGGCAGACCGATGCCAAGACCGGCAAACCGCTCGTCGACGTCATCGTGGACCGGGC
CGAGCAGAAAGGCACCGGCCGTTGGACCGTCAAGTCCGCGCTGGACCTGGGTGTGCCGGTGACCGGCATCGCCGAAGCGG
TGTTTGCCCGCGCTCTCTCGGGATCCGTGGGGCAACGCTCGGCCGCCAGCGGTCTGGCTTCGGGCAAGCTCGGCGAGCAG
CCCGCCGACCCCGCCACGTTCACCGAAGACGTCCGCCAGGCGTTGTACGCCTCCAAGATCGTGGCCTACGCTCAGGGCTT
CAACCAGATCCAGGCCGGCAGCGCCGAATTCGGCTGGGACATCACGCCGGGCGACCTGGCCACCATCTGGCGTGGCGGCT
GCATCATCCGGGCGAAGTTCCTCAACCACATCAAGGAAGCCTTTGACGCCAGCCCGAACCTGGCCAGTCTGATTGTGGCC
CCGTATTTCCGCGGCGCCGTCGAATCGGCGATCGACAGTTGGCGGCGTGTGGTGTCGACGGCGGCCCAACTGGGTATCCC
GACCCCGGGATTCTCGTCGGCCCTGTCGTATTACGACGCGCTGCGCACCGCGCGGCTGCCCGCTGCACTCACCCAGGCCC
AGCGCGACTTCTTCGGCGCACACACCTACGGCCGGATCGACGAACCAGGCAAGTTCCACACACTATGGAGTTCAGACCGC
ACCGAAGTACCGGTGTAG

Upstream 100 bases:

>100_bases
TCCTGGTGGTGCCCACCGTCGCGCTGGCCGTACCGTGGCTCACGCAGCTGCAGCGGCTGTTCATCGCCTAGCGAAGCCGG
GCCCAACTGAAAGGCAGGAC

Downstream 100 bases:

>100_bases
CGGGCTAGAACTAAAAGGGGGTAAAGGGGTAAGTGATGAGATTTCTAGACGGGCACCCACCCGGGTACGACCTGACATAC
AACGACGTGTTCATCGTTCC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLI
MVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQ
SLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYL
VEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQ
PADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVA
PYFRGAVESAIDSWRRVVSTAAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDR
TEVPV

Sequences:

>Translated_485_residues
MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLI
MVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQ
SLGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYL
VEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQ
PADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVA
PYFRGAVESAIDSWRRVVSTAAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDR
TEVPV
>Mature_484_residues
SSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFVRSETIPEFLAALEKPRRVLIM
VKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMRREKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQS
LGPLLEEISAHVDGVPCCTHIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYLV
EITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALSGSVGQRSAASGLASGKLGEQP
ADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWDITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAP
YFRGAVESAIDSWRRVVSTAAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDRT
EVPV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=50.8510638297872, Blast_Score=458, Evalue=1e-129,
Organism=Escherichia coli, GI1788341, Length=466, Percent_Identity=53.6480686695279, Blast_Score=513, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17542558, Length=475, Percent_Identity=47.3684210526316, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6321695, Length=466, Percent_Identity=47.8540772532189, Blast_Score=450, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321977, Length=462, Percent_Identity=49.5670995670996, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24639279, Length=472, Percent_Identity=47.6694915254237, Blast_Score=430, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51548; Mature: 51416

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEE
RSETIPEFLAALEKPRRVLIMVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMR
HHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEHHHHH
REKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCT
HHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEC
HIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYL
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHH
VEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHC
GSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWD
CCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCC
ITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRGAVESAIDSWRRVVST
CCCCHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
TEVPV
CCCCC
>Mature Secondary Structure 
SSSESPAGIAQIGVTGLAVMGSNIARNFARHGYTVAVHNRSVAKTDALLKEHSSDGKFV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCEE
RSETIPEFLAALEKPRRVLIMVKAGEATDADAVINELADAMEPGDIIIDGGNALYTDTMR
HHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEHHHHH
REKAMRERGLHFVGAGISGGEEGALNGPSIMPGGPAESYQSLGPLLEEISAHVDGVPCCT
HHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEC
HIGPDGSGHFVKMVHNGIEYSDMQLIGEAYQLMRDGLGLTAPAIADVFTEWNNGDLDSYL
CCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHH
VEITAEVLRQTDAKTGKPLVDVIVDRAEQKGTGRWTVKSALDLGVPVTGIAEAVFARALS
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHC
GSVGQRSAASGLASGKLGEQPADPATFTEDVRQALYASKIVAYAQGFNQIQAGSAEFGWD
CCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCC
ITPGDLATIWRGGCIIRAKFLNHIKEAFDASPNLASLIVAPYFRGAVESAIDSWRRVVST
CCCCHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAQLGIPTPGFSSALSYYDALRTARLPAALTQAQRDFFGAHTYGRIDEPGKFHTLWSSDR
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
TEVPV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]