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The map label for this gene is cyp144

Identifier: 148661585

GI number: 148661585

Start: 2020588

End: 2021892

Strand: Direct

Name: cyp144

Synonym: MRA_1793

Alternate gene names: 148661585

Gene position: 2020588-2021892 (Clockwise)

Preceding gene: 148661583

Following gene: 148661588

Centisome position: 45.71

GC content: 63.6

Gene sequence:

>1305_bases
GTGAGACGTTCGCCGAAAGGCTCCCCGGGCGCAGTTCTCGACTTGCAGCGACGCGTTGACCAGGCGGTATCCGCCGATCA
CGCTGAACTAATGACAATTGCCAAGGATGCCAACACGTTCTTTGGTGCCGAATCCGTGCAGGACCCCTACCCGCTGTATG
AGCGCATGCGCGCCGCAGGCTCGGTCCACCGGATCGCTAACTCGGACTTCTATGCCGTGTGCGGTTGGGACGCTGTCAAT
GAGGCCATCGGTCGTCCGGAGGACTTCTCCTCGAATTTGACCGCCACGATGACCTATACGGCCGAGGGCACCGCTAAACC
GTTCGAGATGGACCCACTCGGCGGACCCACACACGTGTTGGCCACCGCCGACGATCCTGCCCACGCCGTGCACCGCAAGC
TCGTGCTGCGTCACTTGGCGGCCAAGCGGATCCGCGTTATGGAGCAGTTCACCGTACAGGCTGCCGACCGGCTGTGGGTC
GACGGCATGCAGGATGGGTGCATCGAATGGATGGGCGCCATGGCCAATCGCCTACCGATGATGGTCGTAGCTGAGCTCAT
CGGCCTGCCCGACCCCGACATCGCCCAGCTGGTGAAGTGGGGATACGCGGCCACTCAGCTACTCGAAGGGTTGGTCGAAA
ACGATCAGCTCGTCGCCGCGGGTGTGGCGTTGATGGAGCTCAGCGGTTACATCTTCGAGCAGTTTGACCGTGCCGCGGCC
GATCCGCGGGACAATCTGCTCGGTGAGCTTGCCACCGCCTGCGCATCGGGGGAGCTGGACACTCTCACCGCCCAGGTCAT
GATGGTCACCTTGTTCGCCGCCGGCGGCGAGTCCACGGCGGCGCTGCTGGGCAGCGCGGTATGGATACTGGCGACACGTC
CCGATATCCAGCAACAGGTGCGCGCGAACCCCGAGCTGCTGGGAGCGTTTATCGAAGAGACGCTGCGTTACGAGCCGCCA
TTTCGCGGCCACTACCGCCACGTGCGAAACGCCACCACCTTGGACGGCACGGAACTGCCCGCGGATTCGCACCTGCTGCT
GTTGTGGGGCGCGGCCAACCGCGATCCAGCCCAGTTCGAGGCACCCGGCGAGTTCCGTCTTGACCGTGCAGGAGGCAAAG
GCCACATCAGTTTCGGAAAAGGGGCCCACTTCTGTGTCGGCGCTGCACTGGCACGCTTGGAGGCTCGAATCGTCTTGCGT
CTGCTGCTCGATCGCACCTCGGTAATTGAGGCAGCCGATGTCGGCGGGTGGTTGCCCAGTATCCTGGTGCGCCGCATCGA
GCGGCTAGAGCTAGCTGTACAATAG

Upstream 100 bases:

>100_bases
TGGTCAGGCGCATTTCCATCGAGAGGCGAAGAGCGATTCTTCTCATAGTGAGACACAAGCCTTACTTATTCTCATCGTAG
TTGCAGGTCCGCCTCCCGCG

Downstream 100 bases:

>100_bases
GCGCTCGACGACTCCTATTGCAGCACAACGGATATCAGCAACAGCAGGTGCCAACCGCGGCGATCGGATGCGTGAGAATA
GTGAAAGTGGTTGTCGCGGT

Product: putative cytochrome p450 144 CYP144

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVN
EAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPP
FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLR
LLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ

Sequences:

>Translated_434_residues
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVN
EAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPP
FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLR
LLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
>Mature_434_residues
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVN
EAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPP
FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLR
LLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CP144_MYCTU (O33180)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   B70511
- RefSeq:   NP_216293.1
- RefSeq:   NP_336283.1
- ProteinModelPortal:   O33180
- SMR:   O33180
- EnsemblBacteria:   EBMYCT00000001623
- EnsemblBacteria:   EBMYCT00000072422
- GeneID:   885839
- GeneID:   923821
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1827
- KEGG:   mtu:Rv1777
- TIGR:   MT1827
- TubercuList:   Rv1777
- GeneTree:   EBGT00050000015569
- HOGENOM:   HBG695262
- OMA:   LMWGAAN
- ProtClustDB:   CLSK791388
- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972
- Gene3D:   G3DSA:1.10.630.10
- PANTHER:   PTHR19383
- PRINTS:   PR00359
- PRINTS:   PR00385

Pfam domain/function: PF00067 p450; SSF48264 Cytochrome_P450

EC number: NA

Molecular weight: Translated: 47219; Mature: 47219

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAG
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHH
SVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVL
HHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPM
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
MVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCEEEEEECCCCHHHHH
RANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFE
HCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
APGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPS
CCCCEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ILVRRIERLELAVQ
HHHHHHHHHHHHCC
>Mature Secondary Structure
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAG
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHH
SVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVL
HHHHHCCCCEEEEECHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
ATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPM
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
MVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
DPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCEEEEEECCCCHHHHH
RANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFE
HCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
APGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPS
CCCCEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ILVRRIERLELAVQ
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036