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The map label for this gene is fadD1 [H]

Identifier: 148661549

GI number: 148661549

Start: 1979487

End: 1981085

Strand: Reverse

Name: fadD1 [H]

Synonym: MRA_1761

Alternate gene names: 148661549

Gene position: 1981085-1979487 (Counterclockwise)

Preceding gene: 148661552

Following gene: 148661548

Centisome position: 44.82

GC content: 62.91

Gene sequence:

>1599_bases
ATGACCGACACGATTCAATCGCTCTTGCGCCAGCACGTATCCGATCCAACGATTGCCGTGAAATACGGTGGTCTGCAATG
GACTTGGAGTCAGTACCTGGCGGAGTCGGCGGCCCGCGCGGCGGCCCTCATCACAATCGCCGATCCGCAACGTCCGACGC
ATATCGGCTCTCTGCTGGGGAATACGCCCGAGATGCTGGCCCAGCTGGCTGCGGCCGGGTTGGGCGGCTATGTGCTGTGT
GGCCTGAACACAACGCGACGTGGCGATGCACTGGCCGCTGACGTCAGGCGAGCCGATTGCCAGATCGTGGTGACCGATGC
CGACCACCGAGCGCTGTTGGACGGTTTAGACCTCGCGGGCGCGCGGATCCTTGATACCTCGACACCGCGGTGGGCTGAAT
TGGTGGCTGGTGACGGCGCCTTTGTCCCCTATCGAGAAGTCGACACGATGGATCCGTTCATGATGATCTTCACGTCCGGC
ACCAGCGGAAATCCCAAAGCGGTACCGGTGTCACACCTAATGGCCACGTTCGCCGGGCGTAGCCTCACCGAGCGCTTCGG
GCTCACCGAACAGGACACCTGCTATGTATCCATGCCGCTGTTTCACTCCAACGCGGTGGTCGCGGGATGGGCGCCAGCGG
TGGTCTCCGGTGCCGCGATCGCGCCGGCGACGTTTTCGGCGACCGGCTTCCTCGACGACGTCCGCCGATACCACGCCACT
TATATGAACTACGTCGGCAAGCCGCTCGCCTATATCCTTGCCACCCCCGAACGCGACGACGATGCCGACAATCCGCTGCG
GGTGGCTTTCGGCAACGAGGCCAATGACAAAGACATCGAGGAATTCTCACGCCGCTTCGGAGTCCAGGTCGAGGACGGCT
TTGGCTCGACCGAGAACGCGGTCATCGTGATCCGCGAACCCGGCACGCCACCGGGCTCGATCGGCCGGGGAGCCCACGGG
GTCGCGGTGTACAACGGCGAAACCGTCACCGAGTGCGCCGTCGCGCGGTTCGACGCTCACGGAGCACTCACCAACGCCGA
TGAAGCCATAGGTGAGTTGGTCAACACGACGGGGTCGGGCTTCTTCACCGGCTACTACAATGACCCCGAAGCCAACGCCG
AGCGCATGCGCCACGGCATGTACTGGTCTGGAGACCTCGCATACCGGGACTCTGAAGGCTGGATCTACCTTGCTGGCCGC
ACCGCCGACTGGATGCGGGTAGACGGCGAGAACCTGACAGCGGCACCAATCGAGCGAATTCTATTACGATACAAGGCTAT
TAACCGTGTCGCGGTGTATGCCGTCCCGGACGAATACGTCGGCGATCAGGTGATGGCGGCGTTGGTCTTGCGAGCAGGTG
ACACCTTCGACCCTGACGCGTTCGAAGCATTTCTGGACGCCCAGCCTGACCTATCCACTAAAGCCCGGCCACGATACATC
CGCATCGCGGCCGACCTTCCCAGCACCGCCACACACAAGGTGCTCAAGCGCCAGTTGATCGACGAGGGAACCGCGGTCGG
CAAAGCGGACACCCTGTGGGTGCGCGAACCACGAGGCAGCGCTTACCACCACGCGTCCGGACCGGCAAAAGCGATATGA

Upstream 100 bases:

>100_bases
TTGTCATGTCGCGACCTCCTGGCCATTGATGGCATCGTGGCGATCATGCTGGATGACAGCGTCGCGGCCAAAGCCCGCGA
CTCGACATGGGAGCGAATTC

Downstream 100 bases:

>100_bases
AGTACGGAAAGGTCCGCTCCCCCATTACTCGGCCGGCGTTCTCGGGACGCCCGCAACAGCGGTGAGCGCCAGCCCGTCCG
CTAGTGTTGCGTGCGGTCAA

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLC
GLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSG
TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHAT
YMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHG
VAVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGR
TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYI
RIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI

Sequences:

>Translated_532_residues
MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLC
GLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSG
TSGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHAT
YMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHG
VAVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGR
TADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYI
RIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI
>Mature_531_residues
TDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLGNTPEMLAQLAAAGLGGYVLCG
LNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAGARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGT
SGNPKAVPVSHLMATFAGRSLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHATY
MNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENAVIVIREPGTPPGSIGRGAHGV
AVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSGFFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRT
ADWMRVDGENLTAAPIERILLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYIR
IAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=381, Percent_Identity=29.9212598425197, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI13325057, Length=396, Percent_Identity=29.040404040404, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI62865631, Length=527, Percent_Identity=24.2884250474383, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI13325055, Length=527, Percent_Identity=24.2884250474383, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI13236579, Length=374, Percent_Identity=28.0748663101604, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI38524616, Length=386, Percent_Identity=28.2383419689119, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI40807357, Length=375, Percent_Identity=27.2, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI156151445, Length=364, Percent_Identity=25.2747252747253, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI227499621, Length=311, Percent_Identity=28.2958199356913, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI122937307, Length=381, Percent_Identity=24.1469816272966, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI115511026, Length=380, Percent_Identity=24.2105263157895, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38505220, Length=437, Percent_Identity=24.2562929061785, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI42544132, Length=518, Percent_Identity=22.7799227799228, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI58082049, Length=368, Percent_Identity=24.1847826086957, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI157311624, Length=379, Percent_Identity=23.2189973614776, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI157311622, Length=379, Percent_Identity=23.2189973614776, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI221142682, Length=491, Percent_Identity=24.4399185336049, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=351, Percent_Identity=27.9202279202279, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1786810, Length=518, Percent_Identity=24.9034749034749, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788107, Length=161, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534440, Length=389, Percent_Identity=27.7634961439589, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551278, Length=375, Percent_Identity=28, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=362, Percent_Identity=23.7569060773481, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=402, Percent_Identity=22.8855721393035, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=501, Percent_Identity=21.7564870259481, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=369, Percent_Identity=22.7642276422764, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71983001, Length=558, Percent_Identity=22.7598566308244, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=558, Percent_Identity=22.7598566308244, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=347, Percent_Identity=26.5129682997118, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319515, Length=330, Percent_Identity=23.6363636363636, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=403, Percent_Identity=23.5732009925558, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550496, Length=534, Percent_Identity=25.2808988764045, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552801, Length=534, Percent_Identity=25.6554307116105, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24583465, Length=514, Percent_Identity=25.875486381323, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24583463, Length=514, Percent_Identity=25.875486381323, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI281364798, Length=514, Percent_Identity=25.875486381323, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28573631, Length=378, Percent_Identity=26.984126984127, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI20130353, Length=378, Percent_Identity=26.984126984127, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI18859661, Length=502, Percent_Identity=24.9003984063745, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355181, Length=359, Percent_Identity=24.7910863509749, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648260, Length=477, Percent_Identity=23.8993710691824, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24648257, Length=355, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356947, Length=378, Percent_Identity=24.8677248677249, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356441, Length=384, Percent_Identity=23.4375, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653035, Length=354, Percent_Identity=22.0338983050847, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648253, Length=483, Percent_Identity=23.1884057971014, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 57414; Mature: 57283

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLG
CCHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHC
NTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAG
CCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHCCCCCC
ARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGR
CEEEECCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCC
SLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHAT
HHHHHCCCCCCCCEEEEECEEECCEEEECCCHHHHCCCEECCCCCCCHHHHHHHHHHHHH
YMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENA
HHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEECCCCCCCCE
VIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSG
EEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
FFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTADWMRVDGENLTAAPIERI
EEEEECCCCCCCHHHHHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHH
LLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYI
HHHHHHHCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEE
RIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLG
CHHHHHHHHHHCCCCEEEEEECCEEEHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHC
NTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAG
CCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHCCCCCC
ARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGR
CEEEECCCCCHHHHEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCC
SLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHAT
HHHHHCCCCCCCCEEEEECEEECCEEEECCCHHHHCCCEECCCCCCCHHHHHHHHHHHHH
YMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENA
HHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEECCCCCCCCE
VIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSG
EEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
FFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTADWMRVDGENLTAAPIERI
EEEEECCCCCCCHHHHHCCCEECCCEEEECCCCEEEEECCCCCEEEECCCCCCHHHHHHH
LLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYI
HHHHHHHCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEE
RIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI
EEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA