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The map label for this gene is yebQ [C]

Identifier: 148661429

GI number: 148661429

Start: 1840686

End: 1842101

Strand: Direct

Name: yebQ [C]

Synonym: MRA_1644

Alternate gene names: 148661429

Gene position: 1840686-1842101 (Clockwise)

Preceding gene: 148661428

Following gene: 148661431

Centisome position: 41.64

GC content: 67.02

Gene sequence:

>1416_bases
GTGACCGAAACAGCGAGCGAGACCGGCAGCTGGCGTGAGCTACTGAGCAGGTATCTGGGCACCTCCATAGTGCTGGCCGG
TGGCGTCGCGCTTTACGCCACCAACGAGTTTCTGACAATCAGCCTGCTGCCGAGCACAATCGCCGACATCGGGGGTAGCC
GGCTGTACGCCTGGGTGACAACCCTGTATCTGGTCGGGTCGGTGGTGGCGGCGACCACCGTCAATACGATGTTGCTGCGC
GTCGGGGCGCGCTCGTCGTATCTGATGGGGTTGGCCGTCTTCGGTCTGGCCAGCCTGGTATGTGCGGCGGCGCCGAGCAT
GCAGATTCTGGTGGCCGGGCGTACCTTGCAAGGAATAGCCGGTGGGCTGCTGGCCGGCCTAGGCTACGCGCTGATCAACT
CGACCTTGCCCAAGTCGCTGTGGACCCGTGGCTCAGCACTGGTGTCGGCGATGTGGGGGGTCGCGACGCTGATCGGACCG
GCGACCGGAGGCCTTTTCGCGCAGCTCGGGCTGTGGCGATGGGCGTTCGGCGTGATGACGTTGCTGACCGCGTTGATGGC
CATGTTGGTGCCGGTCGCGCTCGGTGCCGGGGGGGTCGGCCCGGGCGGCGAGACGCCGGTGGGCAGCACACACAAGGTGC
CGGTGTGGTCGCTATTGCTGATGGGGGCCGCCGCACTGGCGATCAGCGTCGCCGCGCTTCCGAACTACCTCGTCCAGACG
GCCGGGCTGCTAGCCGCCGCCGCGCTGCTGGTTGCGGTGTTTGTGGTAGTCGACTGGCGGATACACGCAGCGGTGTTGCC
GCCCAGCGTATTTGGCTCCGGACCGTTGAAATGGATTTACCTGACCATGTCGGTGCAGATGATTGCGGCAATGGTCGATA
CCTACGTGCCGCTGTTCGGTCAGCGACTGGGACACCTGACCCCGGTGGCAGCCGGGTTCTTGGGTGCCGCGCTGGCGGTG
GGCTGGACGGTCGGTGAGGTCGCCAGCGCCTCGTTGAACAGTGCACGAGTTATCGGGCATGTCGTGGCAGCCGCACCGCT
GGTGATGGCGTCGGGGTTGGCGCTAGGCGCCGTCACCCAGCGCGCCGATGCGCCGGTGGGGATCATCGCGCTGTGGGCGC
TGGCGCTGCTGATCATCGGGACCGGCATCGGGATCGCCTGGCCGCATCTAACGGTGCGCGCTATGGATTCTGTCGCCGAC
CCGGCCGAGAGCAGCGCGGCGGCCGCGGCGATCAATGTCGTACAGCTGATCTCCGGTGCTTTCGGCGCCGGGCTGGCCGG
TGTGGTGGTCAACACTGCCAAGGGCGGCGAAGTGGCGGCGGCTCGTGGGCTATACATGGCATTTACGGTGCTGGCCGCCG
CTGGTGTCATCGCCTCCTACCAGGCCACGCACCGCGACCGGCGCTTACCGCGTTGA

Upstream 100 bases:

>100_bases
CGGCCGCGCGCGACCTGCAGTTCGAGCTGGCGGCCCGGTTCCGCGACGAGATCGCCGACCTCAAGCGGGAGCTGCGGGGG
ATGGACGCGGCCGGCCTGAA

Downstream 100 bases:

>100_bases
CTTGACCACCTGCGAGTAGTGGAACTGCCAGCGCTCGACGATGCGGAAGCCGAGGTAGCTCGGGAACCGGTATACGGGCG
TGCGCCCGAAGCCTGTTCCC

Product: putative drug transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLR
VGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGP
ATGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQT
AGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYLTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAV
GWTVGEVASASLNSARVIGHVVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVAD
PAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR

Sequences:

>Translated_471_residues
MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLR
VGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGP
ATGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQT
AGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYLTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAV
GWTVGEVASASLNSARVIGHVVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVAD
PAESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR
>Mature_470_residues
TETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYLVGSVVAATTVNTMLLRV
GARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPA
TGGLFAQLGLWRWAFGVMTLLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQTA
GLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYLTMSVQMIAAMVDTYVPLFGQRLGHLTPVAAGFLGAALAVG
WTVGEVASASLNSARVIGHVVAAAPLVMASGLALGAVTQRADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVADP
AESSAAAAAINVVQLISGAFGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR

Specific function: Could be involved in fluoroquinolones efflux

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily

Homologues:

Organism=Escherichia coli, GI87081983, Length=134, Percent_Identity=30.5970149253731, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1634_MYCTU (O06151)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842577
- PIR:   H70559
- RefSeq:   NP_216150.1
- RefSeq:   NP_336126.1
- ProteinModelPortal:   O06151
- SMR:   O06151
- EnsemblBacteria:   EBMYCT00000002945
- EnsemblBacteria:   EBMYCT00000068989
- GeneID:   885115
- GeneID:   924194
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1670
- KEGG:   mtu:Rv1634
- TIGR:   MT1670
- TubercuList:   Rv1634
- GeneTree:   EBGT00050000014790
- HOGENOM:   HBG649550
- OMA:   YLTTSLL
- ProtClustDB:   CLSK791293
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 47714; Mature: 47583

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e05fd04)-; HASH(0x1d37f868)-; HASH(0x1e95a338)-; HASH(0x1eadd394)-; HASH(0x1eae6a04)-; HASH(0x1ec1e864)-; HASH(0x1ca8eea8)-; HASH(0x1c8f20c0)-; HASH(0x1b2198e4)-; HASH(0x1e3766f4)-; HASH(0x1d480864)-; HASH(0x1b0f3584)-; HASH(0x1ea46e5c)-; HASH(0x1ea2ae18)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVT
CCCCCCCCCHHHHHHHHHHCCHHHHHCCEEEEEECCEEEEEECHHHHHHCCCCHHHHHHH
TLYLVGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
GGLLAGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLGLWRWAFGVMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LLTALMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQT
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLLAAAALLVAVFVVVDWRIHAAVLPPSVFGSGPLKWIYLTMSVQMIAAMVDTYVPLFG
HHHHHHHHHHHHHHHHHHHHHHEEECCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
QRLGHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGHVVAAAPLVMASGLALGAVTQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
RADAPVGIIALWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGA
HCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRLPR
HCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
TETASETGSWRELLSRYLGTSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVT
CCCCCCCCHHHHHHHHHHCCHHHHHCCEEEEEECCEEEEEECHHHHHHCCCCHHHHHHH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HCCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036