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The map label for this gene is tesB1 [H]

Identifier: 148661413

GI number: 148661413

Start: 1819133

End: 1820035

Strand: Direct

Name: tesB1 [H]

Synonym: MRA_1628

Alternate gene names: 148661413

Gene position: 1819133-1820035 (Clockwise)

Preceding gene: 148661412

Following gene: 148661414

Centisome position: 41.16

GC content: 62.24

Gene sequence:

>903_bases
GTGCCGGACGGTAAACCCATGTCCGACTTCGATGAACTACTGGCGGTATTGGACCTCAACGCCGTCGCAAGCGACCTGTT
CACCGGATCCCACCCCAGCAAAAACCCGCTCCGGACATTTGGTGGCCAGCTCATGGCGCAGTCATTCGTCGCGAGCAGCC
GAACGCTAACCCGCCACCACCTACCGCCCAGCGCATTCTCGGTGCACTTCATCAACGGCGGTGACACGGCCAAGGACATC
GAGTTCCAGGTGATACGACTGCGCGATGAGCGGCGCTTCGCCAACCGGCGCGTCGATGCGGTACAGGACGGCACGTTGCT
GTCCTCGGCGATGGTGTCTTACATGGCCGGTGGTCGCGGGCACGAGCATGCGCTGGATCCGCCGCAGGTGGCCGAGCCTC
ATACCCGGCCGCCGATCGGTGAGCTGTTGCGCGGTTACGAGGAGACCGTCCCGCATTTTGTCAACGCGCTGCAACCGATC
GAATGGCGCTACGCCAACGACCCGGCCTGGATAATGCGGGACAAGGGCGATCGGCTTGCCTACAACCGGGTCTGGGTCAA
GGCACTAGGGGAGATGCCCGACGACCCGGTGCTGCACACGGCGACACTGTTGTACTCCTCGGACACCACCGTGCTGGACT
CGGTCATTACCACCCATGGTCTGTCCTGGGGCTTCGATCGCATCTTTGCGGCCTCTGCCAACCACTCGGTGTGGTTTCAC
CGGCAGGTCAACTTCGATGATTGGGTGCTCTACTCGACGTCGTCACCGGTGGCCGCCGATTCACGTGGGTTGGGTTCGGG
GCACTTTTTTGATCGCTCGGGGAAGCTCATCGCAACTGTGGTGCAGGAAGGTGTGTTGAAGTATTTTCCCGCCACCCCTG
ACAGTGCGGCAGGACGCTCGTAG

Upstream 100 bases:

>100_bases
GACTTGGTGGTCATCGTCGCGGGTGCGCCGCCAGGCACAGTGGGTTCGACCAACCTGATCCACGTGCACCGGATCGGGGA
AGATGACGTCTAGCCGGGTC

Downstream 100 bases:

>100_bases
GATTCCGGGTCAGCACGGCTGTGATCAGGCGTAACGTTCCTGGTAGCCAGATGACCGATGGTGGCAGCGGCCGGCGAGCC
GCTGAATTGCCAGCGAGCGA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDI
EFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRGHEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPI
EWRYANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGFDRIFAASANHSVWFH
RQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVVQEGVLKYFPATPDSAAGRS

Sequences:

>Translated_300_residues
MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDI
EFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRGHEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPI
EWRYANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGFDRIFAASANHSVWFH
RQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVVQEGVLKYFPATPDSAAGRS
>Mature_299_residues
PDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLMAQSFVASSRTLTRHHLPPSAFSVHFINGGDTAKDIE
FQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRGHEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIE
WRYANDPAWIMRDKGDRLAYNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGFDRIFAASANHSVWFHR
QVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVVQEGVLKYFPATPDSAAGRS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=307, Percent_Identity=28.9902280130293, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=31.25, Blast_Score=134, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=27.4914089347079, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558508, Length=316, Percent_Identity=27.5316455696203, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17531889, Length=312, Percent_Identity=27.8846153846154, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532456, Length=312, Percent_Identity=27.8846153846154, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17531885, Length=312, Percent_Identity=27.8846153846154, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33173; Mature: 33041

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLMAQSFVASSRTLTRHH
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHC
LPPSAFSVHFINGGDTAKDIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRG
CCCCCEEEEEECCCCCCCCCEEEEEEEEHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCC
HEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDKGDRLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCEEH
YNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGFDRIFAASANHSVWFH
HHHHHHHHHHCCCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCCCHHHEEECCCCCEEEE
RQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVVQEGVLKYFPATPDSAAGRS
EECCCCCEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PDGKPMSDFDELLAVLDLNAVASDLFTGSHPSKNPLRTFGGQLMAQSFVASSRTLTRHH
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHC
LPPSAFSVHFINGGDTAKDIEFQVIRLRDERRFANRRVDAVQDGTLLSSAMVSYMAGGRG
CCCCCEEEEEECCCCCCCCCEEEEEEEEHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCC
HEHALDPPQVAEPHTRPPIGELLRGYEETVPHFVNALQPIEWRYANDPAWIMRDKGDRLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCEEH
YNRVWVKALGEMPDDPVLHTATLLYSSDTTVLDSVITTHGLSWGFDRIFAASANHSVWFH
HHHHHHHHHHCCCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCCCHHHEEECCCCCEEEE
RQVNFDDWVLYSTSSPVAADSRGLGSGHFFDRSGKLIATVVQEGVLKYFPATPDSAAGRS
EECCCCCEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]