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The map label for this gene is 148661154

Identifier: 148661154

GI number: 148661154

Start: 1536993

End: 1538954

Strand: Reverse

Name: 148661154

Synonym: MRA_1373

Alternate gene names: NA

Gene position: 1538954-1536993 (Counterclockwise)

Preceding gene: 148661155

Following gene: 148661153

Centisome position: 34.82

GC content: 65.44

Gene sequence:

>1962_bases
ATGGCGGCCGAAATGGACTGGGACAAAACGGTCGGTGCGGCCGAGGATGTACGACGCATTTTCGAGCACATCCCTGCGAT
TCTGGTTGGCCTCGAGGGGCCTGACCATCGCTTTGTCGCAGTGAACGCGGCCTATCGCGGCTTCAGTCCATTGCTTGACA
CCGTGGGACAGCCCGCTCGGGAGGTCTATCCCGAACTGGAGGGTCAGCAGATCTACGAAATGTTGGACCGGGTCTATCAA
ACCGGTGAGCCGCAATCAGGATCGGAGTGGCGACTACAAACTGATTACGACGGTTCCGGAGTTGAGGAACGATACTTCGA
CTTTGTCGTCACACCGCGCCGCCGGGCGGACGGATCGATCGAGGGCGTGCAGCTCATTGTGGACGACGTCACCAGCCGAG
TGCGAGCCCGGCAGGCGGCCGAGGCGCGCGTGGAGGAACTGTCCGAGCGCTATCGCAATGTGCGCGATTCAGCCACCGTT
ATGCAGCAGGCGTTGCTGGCCGCGTCGGTGCCCGTGGTTCCCGGCGCCGACATAGCCGCCGAGTACCTGGTCGCCGCCGA
GGATACCGCGGCCGGCGGCGACTGGTTCGACGCGCTGGCCCTCGGGGATCGGTTGGTGCTCGTCGTTGGCGACGTCGTGG
GCCACGGCGTGGAGGCCGCAGCGGTCATGTCGCAATTACGTACGGCGTTACGCATGCAGATCTCGGCGGGGTACACGGTC
GTCGAGGCGCTTGAGGCAGTGGACCGCTTCCATAAACAGGTACCTGGATCGAAATCGGCCACCATGTGTGTCGGCTCGCT
CGACTTCACCTCGGGCGAATTCCAGTACTGCACAGCCGGACACCCGCCACCGCTGCTGGTGACCGCGGACGCGAGTGCGC
GGTATGTCGAACCAACCGGCGCGGGTCCGCTCGGCAGCGGAACCGGATTTCCAGTGCGCAGTGAAGTGCTCAACATCGGC
GACGCGATCCTCTTTTACACTGACGGCCTGATCGAGCGGCCCGGTCGGCCGCTCGAGGCCAGCACCGCCGAATTTGCCGA
CCTAGCGGCCAGCATCGCCAGCGGCAGTGGCGGCTTTGTGCTCGACGCCCCGGCACGGCCCATCGACCGACTCTGTTCGG
ACACACTTGAATTGCTGCTGCGGTCCACCGGCTACAACGACGATGTGACCCTGCTTGCGATGCAACGCCGGGCGCCAACG
CCGCCGCTGCACATAACGCTGGATGCGACGATCAACGCGGCACGAACCGTTCGAGCCCAGCTTCGTGAGTGGCTGGCAGA
GATCGGCGCCGACCACTCCGACATCGCCGATATCGTGCACGCGATCTCCGAATTCGTCGAGAACGCGGTCGAACACGGAT
ACGCCACGGACGTCTCCAAGGGCATCGTTGTCGCGGCCGCGCTGGCCGGCGACGGCAACGTGCGGGCATCGGTAATCGAC
CGGGGCCAATGGAAGGACCACCGCGACGGCGCCCGTGGCCGTGGGCGCGGCCTGGCGATGGCCGAGGCCCTAGTGTCGGA
GGCGCGCATCATGCATGGCGCCGGCGGAACGACTGCCACACTTACGCATCGCCTGTCGCGGCCGGCGCGGTTTGTCACCG
ACACGATGGTTCGCCGGGCAGCTTTCCAACAAACCATCGACAGCGAATTCGTCTCCCTAGTTGAATCCGGCCGCATCGTT
GTCCGGGGCGACGTCGATTCGACCACCGCAGCCACATTGGACCGCCAGATCGCCGTCGAAAGCCGTTCTGGCATAGCACC
CGTGACGATCGACCTCAGTGCCGTCACCCACCTTGGTTCGGCCGGCGTCGGCGCCCTCGCTGCCGCTTGTGACCGGGCAC
GCAAACAGGGGACCGAGTGCGTGCTGGTGGCCCCACCCGGCAGCCCGGCGCACCATGTCTTGTCGCTGGTCCAGCTGCCC
GTTGTCGGCGCCGACACCGAGGACATCTTCGCCCAGGAGTAG

Upstream 100 bases:

>100_bases
AAGCTGGTAGGGCACGTTGATAACCTGGTTGCGTTGCCTGGCGAATTGGTCTGCGCACGTTGACCCGTTTGCTACATCGG
TCCGTAGGAGGGACGGCCAA

Downstream 100 bases:

>100_bases
GCGGCTCAACGAGCCTGCACGGGCGTTCCGTCGACCATCGCCTGCACGCGTTCACGACACGACATGGCACAACCGGGAAT
CTTTTGGAGAAACGCTTGGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQ
TGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATV
MQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTV
VEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIG
DAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPT
PPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIV
VRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLP
VVGADTEDIFAQE

Sequences:

>Translated_653_residues
MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQ
TGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATV
MQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTV
VEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIG
DAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPT
PPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIV
VRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLP
VVGADTEDIFAQE
>Mature_652_residues
AAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQT
GEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVM
QQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVV
EALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGD
AILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTP
PLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVIDR
GQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVV
RGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPV
VGADTEDIFAQE

Specific function: Unknown

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1364_MYCTU (Q11034)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   C70742
- RefSeq:   NP_335859.1
- RefSeq:   YP_177802.1
- PDB:   3K3C
- PDB:   3K3D
- PDB:   3KE6
- PDB:   3KX0
- PDBsum:   3K3C
- PDBsum:   3K3D
- PDBsum:   3KE6
- PDBsum:   3KX0
- ProteinModelPortal:   Q11034
- SMR:   Q11034
- IntAct:   Q11034
- EnsemblBacteria:   EBMYCT00000002512
- EnsemblBacteria:   EBMYCT00000070889
- GeneID:   886802
- GeneID:   924592
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1410
- KEGG:   mtu:Rv1364c
- TIGR:   MT1410
- TubercuList:   Rv1364c
- GeneTree:   EBGT00050000014821
- HOGENOM:   HBG579570
- OMA:   DVDSNTA
- ProtClustDB:   CLSK799795
- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR001932
- InterPro:   IPR002645
- InterPro:   IPR010822
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.750.24
- SMART:   SM00387
- SMART:   SM00086
- SMART:   SM00091
- SMART:   SM00331
- TIGRFAMs:   TIGR00229

Pfam domain/function: PF02518 HATPase_c; PF08448 PAS_4; PF07228 SpoIIE; PF01740 STAS; SSF55874 ATP_bd_ATPase; SSF52091 STAS

EC number: NA

Molecular weight: Translated: 69525; Mature: 69394

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50113 PAC; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR
CCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCHHHHHHHCCCCHH
EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSI
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHEEECCCCCCCCCC
EGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTV
HHHEECCCCCCCCCHHHHHHHCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
VEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTG
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEECCCCCEEECCCC
AGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFV
CCCCCCCCCCCHHHHHHHCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEE
LDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQ
ECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHH
LREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEEEECCCCEEEEEEC
RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGS
HHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHEECCCCCCCEEEEEHHHHHHCCC
AGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
CCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCC
>Mature Secondary Structure 
AAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAR
CCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCHHHHHHHCCCCHH
EVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSI
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHEEECCCCCCCCCC
EGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTV
HHHEECCCCCCCCCHHHHHHHCCEEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCCCHHH
VEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTG
HHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEECCCCCEEECCCC
AGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFV
CCCCCCCCCCCHHHHHHHCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEE
LDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQ
ECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHH
LREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEEEEECCCCEEEEEEC
RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
AFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGS
HHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHEECCCCCCCEEEEEHHHHHHCCC
AGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE
CCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036