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The map label for this gene is pncB1

Identifier: 148661119

GI number: 148661119

Start: 1500523

End: 1501869

Strand: Reverse

Name: pncB1

Synonym: MRA_1338

Alternate gene names: 148661119

Gene position: 1501869-1500523 (Counterclockwise)

Preceding gene: 148661131

Following gene: 148661118

Centisome position: 33.98

GC content: 68.82

Gene sequence:

>1347_bases
GTGGGGCCACCCCCAGCCGCCAGGCGGCGAGAGGGAGAGCCCGACAATCAAGACCCAGCCGGGCTGTTGACCGACAAGTA
CGAGTTGACCATGCTGGCGGCTGCCCTGCGCGACGGCAGCGCCAATCGCCCCACCACATTCGAGGTGTTCGCTCGCCGAC
TCCCCACCGGCCGTCGCTACGGAGTTGTCGCCGGAACCGGCCGGTTGCTGGAAGCGTTGCCGCAGTTCAGGTTCGACGCT
GACGCGTGCGAGTTGCTGGCCCAATTCCTCGACCCGGCCACGGTGCGGTATCTTCGCGAATTCCGGTTCCGCGGCGATAT
CGACGGCTATGCCGAGGGGGAGCTGTATTTTCCCGGGTCACCGGTGCTCTCGGTACGCGGCAGCTTCGCCGAATGCGTCC
TGCTCGAAACGCTGGTGCTGTCAATCTTCAACCACGACACAGCGATCGCCTCGGCAGCGGCGCGCATGGTCAGCGCCGCC
GGGGGGCGCCCACTGATCGAGATGGGCTCGCGGCGCACCCACGAACGCGCCGCGGTGGCAGCGGCCCGGGCGGCGTATAT
CGCCGGTTTCGCCGCGTCATCCAACTTGGCGGCGCAGCGACGCTACGGAGTGCCCGCGCACGGCACCGCGGCACACGCAT
TCACCATGTTGCACGCCCAGCATGGCGGCCCCACCGAACTAGCCGAGCGAGCCGCATTCCGCGCCCAGGTCGAAGCGCTG
GGACCCGGTACCACGCTGCTGGTGGATACCTATGACGTCACGACCGGTGTGGCCAATGCCGTTGCCGCCGCCGGCGCTGA
GCTCGGCGCGATCCGCATCGATTCCGGTGAGCTTGGGGTACTGGCCCGCCAAGCGCGGGAGCAGCTCGACCGGCTAGGAG
CCACCCGGACGCGCATCGTGGTGTCCGGCGACCTTGACGAGTTCAGCATCGCCGCGTTGCGCGGTGAACCCGTCGACAGC
TACGGCGTGGGCACGTCGCTGGTCACCGGGTCGGGCGCGCCGACCGCCAACATGGTCTACAAACTGGTCGAGGTAGACGG
TGTACCGGTGCAAAAGCGCAGCAGCTACAAAGAATCCCCCGGCGGCCGCAAAGAGGCACTGCGGCGCTCCCGTGCGACGG
GCACCATCACCGAGGAGCTCGTGCATCCGGCGGGCCGTCCGCCGGTCATTGTCGAGCCGCACCGGGTTTTGACGCTGCCA
CTGGTCCGCGCCGGGCAACCGGTAGCCGATACCAGCCTGGCCGCGGCACGGCAGCTGGTGGCATCCGGGTTGCGCAGCCT
GCCAGGCGACGGGCTGAAATTGGCACCCGGCGAGCCGGCGATTCCGACACGCACGATCCCGGCCTGA

Upstream 100 bases:

>100_bases
GCCCCAGGATACCCAGCGCACCGTGGCCGCGAGCCGATACCGTGGCGGTGTGAACGACTGGGTCCCAACCGGGCGACGCT
GCGGACCGCGTCGGACCGCT

Downstream 100 bases:

>100_bases
GCGCAAGGATGTGACCACGTCCCGTGTCCGAGTCGGTATCCATGTCTGTGCCTGAGCTGCTTGCCATCGCCGTGGCGGCA
CTTGGCGGCACCCGGCGTCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDA
DACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAA
GGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDS
YGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLP
LVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA

Sequences:

>Translated_448_residues
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDA
DACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAA
GGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDS
YGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLP
LVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA
>Mature_447_residues
GPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDAD
ACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAG
GRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALG
PGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSY
GVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPL
VRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN)

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Homo sapiens, GI194394158, Length=442, Percent_Identity=33.710407239819, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71997947, Length=416, Percent_Identity=31.4903846153846, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71997952, Length=416, Percent_Identity=31.4903846153846, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71997955, Length=200, Percent_Identity=35, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24581587, Length=431, Percent_Identity=31.0904872389791, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI161076680, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581595, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28574709, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581593, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581591, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB1_MYCTU (Q10641)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   F70770
- RefSeq:   NP_215846.2
- RefSeq:   NP_335822.1
- ProteinModelPortal:   Q10641
- SMR:   Q10641
- EnsemblBacteria:   EBMYCT00000000400
- EnsemblBacteria:   EBMYCT00000069774
- GeneID:   886884
- GeneID:   924689
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1372
- KEGG:   mtu:Rv1330c
- TIGR:   MT1372
- TubercuList:   Rv1330c
- GeneTree:   EBGT00050000017207
- HOGENOM:   HBG292386
- OMA:   LSILNHD
- ProtClustDB:   PRK09243
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01513

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 47227; Mature: 47096

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
GVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGS
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVA
CCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHH
AARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV
CCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESP
EECCCCCEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHCCCCCCC
GGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLV
CCHHHHHHHHCCCCCHHHHHHCCCCCCCEEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASGLRSLPGDGLKLAPGEPAIPTRTIPA
HHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEE
GVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGS
EEEECCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
PVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVA
CCEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHH
AARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV
CCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESP
EECCCCCEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCHHHCCCCCCC
GGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLV
CCHHHHHHHHCCCCCHHHHHHCCCCCCCEEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASGLRSLPGDGLKLAPGEPAIPTRTIPA
HHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036