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The map label for this gene is 148661049

Identifier: 148661049

GI number: 148661049

Start: 1411248

End: 1411682

Strand: Reverse

Name: 148661049

Synonym: MRA_1270

Alternate gene names: NA

Gene position: 1411682-1411248 (Counterclockwise)

Preceding gene: 148661053

Following gene: 148661048

Centisome position: 31.94

GC content: 67.13

Gene sequence:

>435_bases
ATGCCCTGCGTGTTCTGTGCGATCATCGCCGGGGAGGCTCCGGCCATCCGGATCTACGAGGACGGCGGCTATCTCGCGAT
CCTCGACATCCGCCCGTTCACCCGCGGCCACACGCTGGTGCTGCCCAAGCGACACACCGTTGACCTCACCGACACCCCGC
CGGAGGCGTTGGCTGACATGGTCGCCATCGGCCAACGCATCGCGCGGGCGGCCCGCGCCACGAAGTTGGCTGACGCGACA
CACATCGCCATCAACGACGGCCGTGCCGCTTTTCAGACGGTGTTCCACGTTCACTTGCACGTATTACCGCCGCGCAACGG
CGACAAGCTGTCGGTCGCCAAGGGAATGATGCTGCGCCGCGACCCGGACCGGGAAGCCACCGGACGGATCCTGCGGGAGG
CGCTGGCGCAACAGGATGCCGCTGCGCAAGACTGA

Upstream 100 bases:

>100_bases
CTGTGCCGCGGCACCGGCGAAGGCCAGGTCAGTAGGGTCCACGGCGGCAGCGTATCCCGTTCACTTGGGCGGTCTCCGAG
AGGTCCAGTACCGTAGCGAC

Downstream 100 bases:

>100_bases
CCCCATGGACATTTCCCGATGGCTTGAGCGCCACGTAGGCGTGCAGCTGCTCAGGCTGCACGACGCGATCTACCGAGGCA
CTAACGGTCGGATCGGACAC

Product: HIT family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADMVAIGQRIARAARATKLADAT
HIAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD

Sequences:

>Translated_144_residues
MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADMVAIGQRIARAARATKLADAT
HIAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD
>Mature_143_residues
PCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADMVAIGQRIARAARATKLADATH
IAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain

Homologues:

Organism=Saccharomyces cerevisiae, GI6320078, Length=139, Percent_Identity=34.5323741007194, Blast_Score=91, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YHI2_MYCTU (Q11066)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   F70753
- RefSeq:   NP_215778.1
- RefSeq:   NP_335745.1
- ProteinModelPortal:   Q11066
- SMR:   Q11066
- EnsemblBacteria:   EBMYCT00000003819
- EnsemblBacteria:   EBMYCT00000071256
- GeneID:   887036
- GeneID:   923190
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1300
- KEGG:   mtu:Rv1262c
- TIGR:   MT1300
- TubercuList:   Rv1262c
- GeneTree:   EBGT00050000015503
- HOGENOM:   HBG743217
- OMA:   NEELAGQ
- ProtClustDB:   CLSK791059
- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310
- Gene3D:   G3DSA:3.30.428.10
- PANTHER:   PTHR23089
- PRINTS:   PR00332

Pfam domain/function: PF01230 HIT; SSF54197 His_triad-like_motif

EC number: NA

Molecular weight: Translated: 15681; Mature: 15550

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00892 HIT_1; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADM
CCEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCEEEECCCCEEECCCCCHHHHHHH
VAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRR
HHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHEEEEEEEEECCCCCCEEHHHHCCCCCC
DPDREATGRILREALAQQDAAAQD
CCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADM
CEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCEEEECCCCEEECCCCCHHHHHHH
VAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRR
HHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHEEEEEEEEECCCCCCEEHHHHCCCCCC
DPDREATGRILREALAQQDAAAQD
CCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036