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The map label for this gene is htrA [H]

Identifier: 148661010

GI number: 148661010

Start: 1367185

End: 1368771

Strand: Direct

Name: htrA [H]

Synonym: MRA_1232

Alternate gene names: 148661010

Gene position: 1367185-1368771 (Clockwise)

Preceding gene: 148661009

Following gene: 148661011

Centisome position: 30.93

GC content: 64.97

Gene sequence:

>1587_bases
GTGGATACTAGGGTGGACACGGACAACGCGATGCCTGCACGTTTTAGCGCCCAGATTCAGAATGAGGATGAGGTGACCTC
CGACCAAGGCAACAACGGCGGCCCGAACGGCGGAGGCCGCCTGGCGCCGCGCCCGGTTTTTCGGCCACCGGTCGACCCGG
CGTCGCGTCAAGCGTTCGGGCGTCCGTCCGGGGTCCAAGGGTCCTTTGTGGCCGAGCGTGTGCGCCCGCAGAAGTACCAG
GACCAGTCTGACTTCACACCGAACGATCAGCTTGCTGACCCGGTGCTTCAGGAGGCGTTCGGTCGTCCGTTCGCGGGCGC
CGAATCGCTGCAGCGCCATCCCATCGATGCCGGAGCGCTGGCAGCTGAGAAAGACGGTGCCGGCCCCGACGAGCCCGACG
ATCCGTGGCGCGACCCCGCGGCCGCGGCCGCGCTGGGGACGCCAGCGCTAGCCGCGCCGGCACCGCACGGTGCGCTGGCC
GGCAGCGGCAAGCTGGGTGTGCGCGACGTGCTGTTTGGCGGCAAGGTGTCCTACTTGGCGCTGGGCATCTTGGTCGCTAT
CGCACTGGTGATCGGCGGCATCGGCGGTGTCATCGGCCGCAAGACCGCGGAAGTAGTCGATGCGTTCACCACGTCGAAGG
TGACCCTGTCGACCACTGGCAATGCCCAGGAACCGGCCGGCCGGTTCACCAAGGTGGCGGCCGCCGTGGCCGATTCGGTG
GTGACCATTGAGTCGGTCAGCGACCAGGAGGGCATGCAAGGTTCCGGCGTCATCGTCGATGGCCGCGGCTACATCGTCAC
CAACAATCACGTGATCTCTGAGGCGGCCAACAATCCCAGCCAGTTCAAGACGACCGTGGTGTTCAACGACGGCAAGGAGG
TGCCCGCCAATCTGGTGGGTCGTGACCCCAAGACCGACTTGGCCGTCCTCAAGGTCGACAACGTCGACAATCTGACCGTG
GCCCGGCTCGGTGATTCCAGCAAGGTACGGGTCGGTGACGAAGTCCTCGCGGTCGGCGCGCCCCTGGGGCTGCGCAGTAC
GGTGACCCAGGGCATTGTCAGCGCGCTACACCGCCCCGTTCCGTTGTCGGGCGAGGGCTCTGACACCGACACCGTCATTG
ACGCAATTCAGACCGACGCCTCGATCAACCACGGTAACTCCGGCGGTCCGCTAATCGACATGGATGCCCAGGTGATTGGC
ATCAACACCGCCGGTAAGTCACTGTCGGATAGCGCCAGCGGGCTGGGCTTTGCGATCCCGGTCAACGAGATGAAATTGGT
GGCAAATTCTCTGATCAAAGACGGAAAGATCGTGCATCCGACGTTGGGCATCAGCACCCGGTCAGTAAGCAACGCGATCG
CGTCGGGCGCGCAGGTGGCCAATGTAAAGGCGGGAAGTCCCGCGCAGAAGGGCGGGATCTTGGAGAACGATGTGATCGTC
AAGGTCGGTAACCGCGCGGTCGCCGACTCCGACGAGTTCGTCGTCGCCGTGCGCCAGTTGGCTATCGGCCAGGACGCTCC
GATAGAGGTGGTCCGCGAGGGTCGGCATGTGACGCTGACGGTGAAACCGGACCCCGATAGCACCTAG

Upstream 100 bases:

>100_bases
GAATCGGGGCCGGCAATCGCGGGTGCGTCGCTAGCCGGTGAGCCACTTGTCGCAGCGCATGGCGGGGTTGCTGCGAGTTC
ATGGCGAGTGGTCGCGATCC

Downstream 100 bases:

>100_bases
AGTGTTCGCCAACATCGGTTGGTGGGAAATGCTCGTCCTCGTCATGGTCGGGCTGGTGGTGCTTGGCCCGGAGCGGCTCC
CGGGTGCCATCCGCTGGGCG

Product: heat shock protein HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQ
DQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALA
GSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTV
ARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIG
INTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST

Sequences:

>Translated_528_residues
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQ
DQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALA
GSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTV
ARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIG
INTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
>Mature_528_residues
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQ
DQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALA
GSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTV
ARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIG
INTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=294, Percent_Identity=35.0340136054422, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=33.9041095890411, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI24308541, Length=290, Percent_Identity=32.0689655172414, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI7019477, Length=302, Percent_Identity=31.7880794701987, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=35.9712230215827, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1789629, Length=284, Percent_Identity=38.0281690140845, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789630, Length=279, Percent_Identity=37.2759856630824, Blast_Score=149, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646839, Length=361, Percent_Identity=30.7479224376731, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 54190; Mature: 54190

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFG
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
RPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGAL
CCCCCCHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCE
AAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLA
EECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
LGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCE
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVG
EEEECCCCCCCCCCCCEEECCCEEEEECCEEEECCCCCCCCEEEEEEEECCCCCCHHHCC
RDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPV
CCCCCCEEEEEECCCCCEEEEECCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHCCCC
PLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEEC
VNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
HHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCEEE
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
EECCEEECCCCHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCC
>Mature Secondary Structure
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFG
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
RPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGAL
CCCCCCHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCE
AAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLA
EECCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
LGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCE
VTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVG
EEEECCCCCCCCCCCCEEECCCEEEEECCEEEECCCCCCCCEEEEEEEECCCCCCHHHCC
RDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPV
CCCCCCEEEEEECCCCCEEEEECCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHCCCC
PLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIP
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCEEEEC
VNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIV
HHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCEEE
KVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
EECCEEECCCCHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]