Click here to switch to the map view.

The map label for this gene is uppS [C]

Identifier: 148660871

GI number: 148660871

Start: 1211904

End: 1212692

Strand: Direct

Name: uppS [C]

Synonym: MRA_1096

Alternate gene names: 148660871

Gene position: 1211904-1212692 (Clockwise)

Preceding gene: 148660869

Following gene: 148660872

Centisome position: 27.42

GC content: 65.02

Gene sequence:

>789_bases
GTGGAGATCATCCCGCCGCGGCTCAAAGAGCCGTTGTACCGGCTCTACGAGCTGCGCCTGCGGCAGGGCTTGGCCGCCTC
GAAATCCGACCTGCCCCGGCACATAGCCGTGCTGTGCGACGGCAACCGGCGATGGGCGCGCAGCGCGGGCTACGACGACG
TCAGCTACGGCTACCGGATGGGTGCGGCCAAGATCGCCGAAATGCTGCGGTGGTGCCACGAAGCCGGCATCGAACTGGCC
ACCGTCTATCTGCTGTCCACCGAAAACCTGCAGCGCGATCCCGACGAGCTTGCAGCACTCATCGAGATCATCACCGATGT
CGTGGAAGAGATCTGCGCACCGGCCAACCACTGGAGTGTGCGGACGGTCGGGGATCTGGGGTTGATCGGCGAGGAACCGG
CCCGGCGGCTGCGCGGTGCGGTGGAATCCACCCCGGAGGTGGCCTCGTTTCATGTCAACGTTGCTGTTGGCTACGGCGGG
CGCCGCGAGATCGTCGACGCTGTGCGCGCGTTGTTGAGCAAGGAACTCGCCAACGGGGCCACCGCGGAGGAACTCGTCGA
CGCGGTGACCGTCGAGGGTATCTCGGAAAACCTGTACACCTCAGGCCAACCCGACCCCGATTTGGTGATACGCACCTCCG
GCGAGCAACGCTTGTCCGGGTTCTTGCTGTGGCAAAGCGCCTACTCGGAGATGTGGTTCACCGAGGCGCACTGGCCGGCG
TTTCGCCACGTCGATTTTCTACGCGCGCTGCGTGACTACAGTGCGAGGCATCGCAGCTACGGCAGGTGA

Upstream 100 bases:

>100_bases
GCCTCGTCTTGTGCTTGCCGGTGGGTGTCGTCGAACACAGTAGTCGGGCCAGGTAGCGGACATCTGACTCGACGTCTGGG
TCACAGTAGTCTGGGTATCT

Downstream 100 bases:

>100_bases
ATCCGGCGCAGGACGCCTATGTTGCGCTGTTCGGCTGCCTGCGCAGAGTGCACATTAGCCGGCTCGTCATGCTGTGCAAT
CTGCCCAGGTGAAACCCGGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRSYGR

Sequences:

>Translated_262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRSYGR
>Mature_262_residues
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELA
TVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGG
RREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
FRHVDFLRALRDYSARHRSYGR

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=234, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI45580742, Length=234, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=2e-31,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=33.7662337662338, Blast_Score=131, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=28.755364806867, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=237, Percent_Identity=32.0675105485232, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=247, Percent_Identity=23.8866396761134, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=34.4827586206897, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 29411; Mature: 29411

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHH
GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA
EECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
FRHVDFLRALRDYSARHRSYGR
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRM
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCHHHHHHH
GAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSV
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
RTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGA
EECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAHWPA
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCH
FRHVDFLRALRDYSARHRSYGR
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]