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The map label for this gene is grcC2 [H]

Identifier: 148660770

GI number: 148660770

Start: 1107713

End: 1108690

Strand: Reverse

Name: grcC2 [H]

Synonym: MRA_0996

Alternate gene names: 148660770

Gene position: 1108690-1107713 (Counterclockwise)

Preceding gene: 148660771

Following gene: 148660766

Centisome position: 25.08

GC content: 64.62

Gene sequence:

>978_bases
ATGATCCCGGCAGTCAGCCTGGGTGACCCGCAATTCACCGCCAACGTCCACGACGGGATTGCCCGGATTACAGAGCTGAT
CAATAGCGAACTCTCCCAGGCCGACGAGGTTATGCGCGACACGGTGGCGCACCTTGTCGACGCCGGCGGCACCCCGTTTA
GACCGCTTTTCACGGTGCTTGCGGCGCAACTGGGCTCCGACCCCGACGGATGGGAGGTCACGGTCGCGGGGGCAGCCATC
GAGTTGATGCACCTGGGGACGCTTTGTCACGACAGAGTCGTGGATGAGTCCGACATGAGCCGCAAGACACCTAGCGACAA
CACACGCTGGACCAACAACTTCGCAATCCTCGCCGGTGACTACCGATTCGCGACGGCCTCACAGCTAGCCTCGCGGCTGG
ACCCCGAGGCCTTCGCGGTCGTCGCCGAGGCGTTCGCCGAGCTGATCACCGGGCAGATGCGCGCGACCCGGGGCCCCGCC
TCGCATATCGACACGATCGAGCATTACCTCCGAGTCGTGCACGAGAAGACCGGCTCTCTCATCGCAGCATCCGGACAGCT
CGGAGCGGCACTCTCCGGCGCCGCCGAAGAGCAGATCCGCCGCGTAGCGCGCTTGGGGCGCATGATCGGTGCTGCGTTTG
AGATCTCGCGCGACATCATCGCCATCTCCGGTGACTCCGCTACGCTATCGGGCGCCGACCTTGGCCAAGCTGTCCACACG
CTGCCGATGCTCTACGCGCTGCGTGAGCAGACACCCGACACAAGCCGGCTGCGTGAGTTGCTGGCCGGACCGATCCACGA
CGACCACGTCGCCGAAGCCCTCACACTGCTGCGTTGCTCACCGGGCATAGGAAAGGCCAAGAATGTGGTAGCCGCCTATG
CCGCACAGGCGCGAGAGGAGCTCCCCTATTTGCCTGACCGCCAACCTCGCCGAGCCCTTGCGACATTGATCGACCACGCG
ATATCTGCGTGCGACTAG

Upstream 100 bases:

>100_bases
TGCGGCGCTGGGTCAGACGGTGACGCTGACCCTGCACTGAACACGCCATACCTTATCTTGTACACGTGTCAATGTTGTGC
GCATGCCTACGGCCACGAGC

Downstream 100 bases:

>100_bases
CGACACACCCCAGCAACTACCTGTTGACACAACGACGAATAAGTACTCTAGGGTTTGCAGCGATATCACAACTGCCCGAC
GACCATTCGAGAGCCTCTAA

Product: polyprenyl-diphosphate synthase GrcC2

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAI
ELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPA
SHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT
LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHA
ISACD

Sequences:

>Translated_325_residues
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAI
ELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPA
SHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT
LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHA
ISACD
>Mature_325_residues
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAI
ELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPA
SHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT
LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHA
ISACD

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=308, Percent_Identity=25, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789578, Length=241, Percent_Identity=31.5352697095436, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=274, Percent_Identity=30.6569343065693, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=27.8523489932886, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651612, Length=226, Percent_Identity=27.8761061946903, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 34758; Mature: 34758

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVL
CCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGD
HHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEECCCEEEEECC
YRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCE
IAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREE
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LPYLPDRQPRRALATLIDHAISACD
CCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVL
CCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGD
HHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCEECCCEEEEECC
YRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSL
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCE
IAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHT
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH
LPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREE
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LPYLPDRQPRRALATLIDHAISACD
CCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]