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The map label for this gene is accD2 [H]

Identifier: 148660754

GI number: 148660754

Start: 1087064

End: 1088653

Strand: Reverse

Name: accD2 [H]

Synonym: MRA_0981

Alternate gene names: 148660754

Gene position: 1088653-1087064 (Counterclockwise)

Preceding gene: 148660755

Following gene: 148660753

Centisome position: 24.63

GC content: 66.1

Gene sequence:

>1590_bases
GTGCTGCAATCCACACTGGACCCGAACGCTTCCGCCTACGACGAGGCGGCCGCGACGATGAGCGGCAAGCTCGACGAGAT
CAACGCCGAACTGGCCAAGGCGCTCGCCGGCGGTGGCCCCAAATACGTCGACCGGCACCACGCCCGCGGCAACCTGACAC
CACGGGAACGCATCGAGCTGCTCGTCGACCCGGACTCCCCGTTCCTGGAGCTGAGCCCGCTGGCCGCCTACGGCAGCAAC
TTCCAGATCGGCGCCAGCCTGGTCACCGGCATCGGCGCGGTCTGCGGCGTGGAATGCATGATCGTCGCCAACGACCCGAC
GGTCAAGGGCGGCACCAGCAATCCGTGGACGCTTCGAAAGATACTGCGGGCCAACCAGATCGCCTTCGAAAACCGGCTTC
CCGTCATTTCGCTGGTGGAATCCGGCGGGGCCGATCTGCCCACCCAGAAAGAGATTTTCATCCCCGGCGGACAGATGTTC
CGCGACCTGACCCGGCTGTCGGCGGCCGGGATCCCGACCATTGCGCTGGTTTTCGGCAACTCCACCGCGGGCGGTGCCTA
CGTCCCCGGCATGTCCGATCACGTGGTGATGATCAAGGAACGCTCCAAGGTGTTTTTGGCCGGCCCGCCGCTAGTGAAGA
TGGCCACCGGCGAAGAGTCCGACGACGAGTCGCTGGGCGGCGCCGAAATGCACGCCCGCATATCGGGTTTGGCCGACTAT
TTTGCGCTCGACGAGCTCGACGCGATCCGCATCGGACGCCGCATCGTGGCGCGACTGAACTGGATCAAACAGGGACCCGC
ACCCGCTCCGGTGACCGAGCCGCTGTTCGACGCCGAGGAGCTAATCGGCATCGTGCCCCCGGATCTGCGCATCCCATTCG
ACCCGCGCGAGGTGATCGCCCGCATCGTCGATGGCTCCGAGTTCGACGAATTCAAGCCGCTGTACGGGTCGTCTCTGGTG
ACCGGCTGGGCTCGGTTGCACGGCTATCCGCTGGGCATCCTGGCCAACGCCCGCGGCGTGCTGTTCAGCGAGGAATCACA
GAAGGCCACCCAGTTCATCCAGCTGGCCAACCGGGCCGACACGCCGCTGTTGTTCTTACACAACACCACCGGCTACATGG
TGGGCAAGGACTACGAGGAAGGCGGGATGATCAAGCATGGCTCGATGATGATCAACGCCGTGTCCAACTCGACCGTCCCG
CACATCTCGCTGCTGATCGGCGCGTCCTACGGCGCCGGGCACTACGGCATGTGCGGGCGCGCCTACGACCCGCGCTTCCT
ATTCGCCTGGCCCAGCGCCAAGTCCGCGGTGATGGGCGGCGCCCAGCTGTCGGGCGTGCTGTCCATCGTGGCCCGGGCGG
CAGCCGAAGCCCGCGGGCAGCAAGTCGACGAAGCCGCCGACGCGGCGATGCGGGCCGCCGTCGAGGGCCAGATCGAAGCC
GAGTCGCTACCGTTGGTGCTGTCCGGGATGCTTTACGACGACGGGGTGATCGACCCGCGCGACACCCGCACCGTGCTGGG
AATGTGTTTGTCCGCCATCGCCAATGGCCCGATCAAGGGGACGTCGAACTTCGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
AACGCCAATACCGGGACATGCGAATCCTCGGTATCGGAGGCGGCACCACCGAAATACTGACCGCTTTGGCCGCCAAAACC
CTGGGGTATCAATCGTGACC

Downstream 100 bases:

>100_bases
TGCTGATGGGAATCACTCGAGTATTGGTTGCTAACCGCGGCGAGATCGCCCGGCGGGTGTTCGCCACCTGCCGCCGGCTG
GGGCTCGGCACCGTCGCCGT

Product: propionyl-CoA carboxylase subunit beta AccD2

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM

Sequences:

>Translated_529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
>Mature_529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=531, Percent_Identity=49.5291902071563, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=31.1154598825832, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=30.1318267419962, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI310133460, Length=138, Percent_Identity=47.1014492753623, Blast_Score=104, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17552936, Length=535, Percent_Identity=46.7289719626168, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI25147362, Length=510, Percent_Identity=30.3921568627451, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI25147359, Length=513, Percent_Identity=30.2144249512671, Blast_Score=218, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24586065, Length=552, Percent_Identity=47.1014492753623, Blast_Score=510, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56257; Mature: 56257

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIEL
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCEEE
LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
EECCCCCCEEECCHHHCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECC
STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
CCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHH
RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD
HHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCC
TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR
CCEEEEECCCCEEECCCCCCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCC
AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
CCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
CCCCEEEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
>Mature Secondary Structure
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGNLTPRERIEL
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCEEE
LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
EECCCCCCEEECCHHHCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECC
STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
CCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHH
RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD
HHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCC
TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR
CCEEEEECCCCEEECCCCCCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCC
AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
CCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
CCCCEEEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]