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The map label for this gene is sucD [H]

Identifier: 148660731

GI number: 148660731

Start: 1064448

End: 1065359

Strand: Direct

Name: sucD [H]

Synonym: MRA_0959

Alternate gene names: 148660731

Gene position: 1064448-1065359 (Clockwise)

Preceding gene: 148660730

Following gene: 148660733

Centisome position: 24.08

GC content: 62.72

Gene sequence:

>912_bases
ATGACTCACATGTCCATATTTCTGAGCAGGGACAACAAGGTCATTGTGCAGGGCATCACCGGCAGTGAGGCCACCGTCCA
TACCGCGCGAATGCTGCGGGCGGGCACGCAAATCGTCGGCGGTGTGAACGCACGCAAAGCGGGCACCACCGTCACGCATG
AGGATAAGGGCGGCCGGCTGATCAAGCTGCCGGTGTTCGGCAGTGTCGCGGAGGCGATGGAAAAGACCGGCGCCGATGTG
TCGATCATCTTCGTGCCGCCGACGTTCGCCAAGGACGCCATCATCGAGGCCATCGACGCCGAAATTCCGCTGTTGGTTGT
GATCACCGAGGGAATTCCGGTGCAGGACACCGCCTATGCCTGGGCCTACAACCTCGAGGCTGGCCACAAGACCCGCATCA
TTGGCCCCAACTGTCCTGGCATTATCAGTCCCGGTCAGTCGCTGGCCGGTATCACGCCGGCCAACATCACCGGACCCGGT
CCAATTGGTCTGGTGTCCAAGTCGGGGACGTTGACCTACCAGATGATGTTCGAACTGCGCGACCTTGGATTCTCCACGGC
GATCGGCATCGGTGGTGATCCGGTGATTGGCACTACCCACATCGACGCCATCGAGGCCTTCGAGAGGGATCCGGACACCA
AGCTCATCGTGATGATCGGCGAGATCGGTGGTGACGCCGAGGAGCGGGCCGCAGACTTCATCAAGACCAACGTGTCCAAG
CCGGTCGTCGGCTATGTCGCCGGATTTACCGCACCCGAAGGCAAGACGATGGGCCACGCCGGCGCCATCGTCTCCGGCTC
GTCTGGCACAGCGGCGGCCAAGCAAGAGGCCCTGGAGGCCGCCGGTGTGAAGGTCGGCAAGACCCCATCGGCGACCGCGG
CGCTGGCCCGGGAGATCTTGCTCAGTCTCTAG

Upstream 100 bases:

>100_bases
CCTGACCGAGGCCAACCACCCCCTGGTGACACTGGTGGCGACGATGGACGAAGCCGCCGACAAGGCCGCTGAGCTGGCGA
GCGCCTGAGCGAAAGGACCC

Downstream 100 bases:

>100_bases
GGCGAGCAGACGCATAAGCCCCCGCACGCTCGGCGTGTCGGGGGCTTATGCGTCTGCTCGCCCTATACGCAACAGGCCAA
CTTGGCGGCCAGCCGCTCCA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADV
SIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPG
PIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL

Sequences:

>Translated_303_residues
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADV
SIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPG
PIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL
>Mature_302_residues
THMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVS
IIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGP
IGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSKP
VVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=295, Percent_Identity=48.4745762711864, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI38569423, Length=255, Percent_Identity=32.9411764705882, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI38569421, Length=255, Percent_Identity=32.9411764705882, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1786949, Length=283, Percent_Identity=54.7703180212014, Blast_Score=288, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17550194, Length=295, Percent_Identity=51.1864406779661, Blast_Score=257, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17553126, Length=306, Percent_Identity=48.6928104575163, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17557344, Length=245, Percent_Identity=29.3877551020408, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17551266, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=295, Percent_Identity=46.7796610169492, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21356559, Length=308, Percent_Identity=47.4025974025974, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI28574296, Length=295, Percent_Identity=47.7966101694915, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI281363477, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363475, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281363473, Length=253, Percent_Identity=30.8300395256917, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 31229; Mature: 31098

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRL
CCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCCEE
IKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
WAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELR
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEHHHH
DLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
HCCCEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREIL
CEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSL
HCC
>Mature Secondary Structure 
THMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRL
CCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCEEEECCCCCEE
IKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYA
EEECCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCEEE
WAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELR
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEHHHH
DLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSK
HCCCEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREIL
CEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]