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The map label for this gene is ydfG [C]

Identifier: 148660724

GI number: 148660724

Start: 1055555

End: 1056316

Strand: Direct

Name: ydfG [C]

Synonym: MRA_0952

Alternate gene names: 148660724

Gene position: 1055555-1056316 (Clockwise)

Preceding gene: 148660723

Following gene: 148660728

Centisome position: 23.88

GC content: 65.62

Gene sequence:

>762_bases
ATGCTCACCGGAGTGACTCGCCAGAAGATCCTGATCACCGGCGCCAGTTCCGGCCTGGGCGCCGGGATGGCCCGATCCTT
CGCCGCCCAGGGCCGCGACCTGGCGCTCTGCGCCCGCCGCACGGATCGGCTGACCGAACTGAAAGCCGAACTGTCGCAAC
GGTATCCCGACATCAAGATCGCTGTCGCGGAGCTGGACGTCAACGACCACGAGCGGGTGCCCAAGGTATTCGCCGAACTC
AGCGATGAGATTGGCGGCATTGACCGTGTGATCGTCAACGCCGGAATCGGCAAGGGTGCCCGGCTGGGCTCGGGCAAGCT
GTGGGCGAACAAGGCAACCATCGAAACCAACCTGGTCGCCGCACTCGTGCAGATCGAAACGGCACTGGACATGTTCAACC
AGCGCGGTTCGGGGCATTTGGTGCTCATCTCCTCAGTGCTCGGCGTCAAAGGGGTGCCGGGCGTCAAAGCCGCGTATGCG
GCAAGCAAAGCCGGTGTGCGCTCGCTAGGCGAATCGCTGCGCGCCGAGTACGCCCAACGCCCCATCAGGGTCACGGTGCT
GGAGCCGGGTTATATCGAGTCGGAGATGACGGCCAAATCGGCGAGCACAATGTTGATGGTGGACAACGCAACTGGCGTCA
AGGCGCTGGTGGCCGCCATCGAGCGCGAGCCCGGACGCGCCGCGGTCCCCTGGTGGCCATGGGCGCCACTGGTGCGGCTG
ATGTGGGTGCTGCCGCCGCGGCTGACCAGACGCTTCGCCTAG

Upstream 100 bases:

>100_bases
TGTCCTTCGCGGACAAGTCTTTTCAGTACTGTCCAACGTGTCAGACCGGTGGCAAGGCGCTGGCCGACCGGCGTATGTCG
CGGCTGCTCAAGTAGTCGAT

Downstream 100 bases:

>100_bases
CGGGCGCTCGGCCACCTAGCCCGCGCGGCCACGTTCGGTGCGGTAGCGGCGCACCAGCCCGTCGGTCGAGCTGTCCGACT
GCGGTGGCGGTGAACCGGCG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKIAVAELDVNDHERVPKVFAEL
SDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYA
ASKAGVRSLGESLRAEYAQRPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRL
MWVLPPRLTRRFA

Sequences:

>Translated_253_residues
MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKIAVAELDVNDHERVPKVFAEL
SDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYA
ASKAGVRSLGESLRAEYAQRPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRL
MWVLPPRLTRRFA
>Mature_253_residues
MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKIAVAELDVNDHERVPKVFAEL
SDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYA
ASKAGVRSLGESLRAEYAQRPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRL
MWVLPPRLTRRFA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI109715829, Length=195, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI157739938, Length=203, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI40254992, Length=186, Percent_Identity=28.494623655914, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI7706318, Length=202, Percent_Identity=29.7029702970297, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI7657478, Length=201, Percent_Identity=31.3432835820896, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI40807363, Length=228, Percent_Identity=28.5087719298246, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4503817, Length=183, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI226371731, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19743808, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI32455239, Length=207, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031765, Length=207, Percent_Identity=27.536231884058, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=32.258064516129, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=32.620320855615, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=34.1836734693878, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786701, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=202, Percent_Identity=27.2277227722772, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=234, Percent_Identity=28.6324786324786, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997402, Length=192, Percent_Identity=28.125, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=248, Percent_Identity=27.4193548387097, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=256, Percent_Identity=26.953125, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=253, Percent_Identity=26.8774703557312, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532725, Length=246, Percent_Identity=25.2032520325203, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358495, Length=212, Percent_Identity=33.0188679245283, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI116007236, Length=195, Percent_Identity=31.2820512820513, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571387, Length=229, Percent_Identity=31.0043668122271, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI116007238, Length=183, Percent_Identity=31.6939890710383, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=28.1407035175879, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641388, Length=203, Percent_Identity=31.5270935960591, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24641232, Length=199, Percent_Identity=29.6482412060301, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI116007234, Length=217, Percent_Identity=29.4930875576037, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644339, Length=195, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648693, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355889, Length=195, Percent_Identity=28.2051282051282, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648944, Length=198, Percent_Identity=29.2929292929293, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=30.6878306878307, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007232, Length=187, Percent_Identity=31.0160427807487, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281364494, Length=199, Percent_Identity=28.643216080402, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): Y945_MYCTU (P71564)

Other databases:

- EMBL:   BX842575
- EMBL:   AE000516
- PIR:   G70715
- RefSeq:   NP_215460.1
- RefSeq:   NP_335405.1
- ProteinModelPortal:   P71564
- SMR:   P71564
- EnsemblBacteria:   EBMYCT00000002852
- EnsemblBacteria:   EBMYCT00000072195
- GeneID:   885629
- GeneID:   926362
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0971
- KEGG:   mtu:Rv0945
- TIGR:   MT0971
- TubercuList:   Rv0945
- GeneTree:   EBGT00070000031746
- HOGENOM:   HBG750976
- OMA:   MVDNETG
- ProtClustDB:   PRK08251
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27139; Mature: 27139

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 159-159 BINDING 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKI
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEE
AVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVA
EEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHH
ALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYAASKAGVRSLGESLRAEYAQR
HHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRL
CEEEEEECCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MWVLPPRLTRRFA
HHHCCHHHHHCCC
>Mature Secondary Structure
MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKI
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEE
AVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVA
EEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCCCHHHHHHH
ALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYAASKAGVRSLGESLRAEYAQR
HHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRL
CEEEEEECCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MWVLPPRLTRRFA
HHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036