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The map label for this gene is pcp

Identifier: 148660085

GI number: 148660085

Start: 388510

End: 389178

Strand: Direct

Name: pcp

Synonym: MRA_0328

Alternate gene names: 148660085

Gene position: 388510-389178 (Clockwise)

Preceding gene: 148660082

Following gene: 148660086

Centisome position: 8.79

GC content: 65.92

Gene sequence:

>669_bases
ATGTCGAAGGTGCTGGTCACCGGATTCGGACCCTACGGCGTGACGCCGGTAAATCCGGCACAGCTCACCGCCGAAGAGCT
GGATGGTCGCACCATCGCCGGCGCAACGGTCATCTCGCGGATCGTGCCCAACACGTTCTTCGAGTCGATCGCGGCAGCTC
AGCAGGCCATCGCAGAGATCGAGCCAGCATTGGTGATCATGCTGGGCGAATACCCGGGACGCAGCATGATCACCGTCGAG
CGACTCGCGCAAAACGTCAACGACTGCGGGCGGTACGGCCTCGCCGACTGCGCCGGCAGGGTTTTGGTCGGTGAGCCAAC
CGACCCCGCCGGCCCGGTCGCCTACCACGCGACCGTACCGGTTCGCGCGATGGTGCTGGCCATGCGAAAGGCCGGCGTGC
CAGCTGACGTCTCGGACGCGGCGGGCACGTTCGTGTGCAATCACCTCATGTACGGCGTGCTGCACCACCTCGCCCAGAAG
GGTCTGCCCGTCCGCGCCGGTTGGATTCATCTGCCGTGCCTGCCCAGCGTCGCCGCACTGGATCACAACCTCGGTGTTCC
GAGCATGTCGGTCCAGACGGCGGTCGCCGGGGTCACGGCTGGCATCGAGGCAGCCATTCGGCAGTCCGCAGATATCCGCG
AACCGATCCCGTCGCGATTGCAGATCTAG

Upstream 100 bases:

>100_bases
GGTCGAAGATCTCGGCTCGGGCACGCTTGAACATTGTGACGGCTAGTGACAAATGCAGCGACTTTCGGGGAAACGGGCAT
TGAAATAAGGAAGGAACAGC

Downstream 100 bases:

>100_bases
GGCGCAGCTGACGGCGGTCTTCTAGAGATTAGATATTTATTCTTCCGTTATCTTGTCGTAATCTGCTCAGCGTGGGCCGA
CATGAATTAGCTAGGGACCG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVE
RLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQK
GLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI

Sequences:

>Translated_222_residues
MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVE
RLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQK
GLPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI
>Mature_221_residues
SKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEIEPALVIMLGEYPGRSMITVER
LAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVPVRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKG
LPVRAGWIHLPCLPSVAALDHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_MYCBO (P0A5R5)

Other databases:

- EMBL:   U91845
- EMBL:   BX248335
- RefSeq:   NP_853991.1
- ProteinModelPortal:   P0A5R5
- SMR:   P0A5R5
- MEROPS:   C15.001
- EnsemblBacteria:   EBMYCT00000016924
- GeneID:   1091190
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0327
- GeneTree:   EBGT00050000018696
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13195
- BioCyc:   MBOV233413:MB0327-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23193; Mature: 23062

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 146-146 ACT_SITE 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEI
CCCEEEEECCCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVP
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCCCEEEECHHH
VRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLPVRAGWIHLPCLPSVAAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHH
DHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure 
SKVLVTGFGPYGVTPVNPAQLTAEELDGRTIAGATVISRIVPNTFFESIAAAQQAIAEI
CCEEEEECCCCCCCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EPALVIMLGEYPGRSMITVERLAQNVNDCGRYGLADCAGRVLVGEPTDPAGPVAYHATVP
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCCCCCEEEECHHH
VRAMVLAMRKAGVPADVSDAAGTFVCNHLMYGVLHHLAQKGLPVRAGWIHLPCLPSVAAL
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHH
DHNLGVPSMSVQTAVAGVTAGIEAAIRQSADIREPIPSRLQI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972