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The map label for this gene is fadA2 [H]

Identifier: 148660008

GI number: 148660008

Start: 293533

End: 294855

Strand: Direct

Name: fadA2 [H]

Synonym: MRA_0252

Alternate gene names: 148660008

Gene position: 293533-294855 (Clockwise)

Preceding gene: 148660005

Following gene: 148660010

Centisome position: 6.64

GC content: 67.88

Gene sequence:

>1323_bases
GTGGCCCCTGCTGCTAAGAACACTTCACAGACCAGGCGGCGAGTCGCCGTACTGGGCGGCAACCGCATCCCGTTCGCCAG
ATCGGACGGTGCCTACGCGGATGCGTCCAACCAGGACATGTTCACCGCGGCGCTGAGCGGCTTGGTGGACCGATTCGGAC
TCGCCGGCGAGCGGCTGGACATGGTGGTGGGCGGTGCGGTGCTCAAACACAGCCGCGACTTCAATCTAATGCGCGAATGC
GTGCTGGGCTCCGAACTCTCGCCGTACACGCCGGCGTTCGACCTGCAGCAGGCCTGCGGGACGGGCCTGCAGGCCGCGAT
CGCGGCCGCCGACGGCATTGCCGCCGGGCGGTATGAGGTGGCCGCCGCTGGCGGGGTGGACACCACCTCGGACCCGCCGA
TCGGCCTGGGCGACGACCTGCGCCGCACCCTGCTCAAGCTGCGCCGATCTAGGTCCAACGTGCAACGCCTCAAGCTGGTG
GGCACGCTGCCGGCCAGCCTGGGCGTGGAGATCCCCGCCAACAGCGAGCCGCGCACCGGGCTGTCGATGGGCGAGCACGC
CGCCGTCACCGCCAAGCAGATGGGCATCAAACGCGTAGACCAGGACGAGCTGGCCGCCGCCAGCCATCGCAATATGGCCG
ACGCCTACGACCGGGGTTTCTTCGACGACCTGGTCAGTCCGTTTTTAGGGCTGTACCGAGACGACAATCTGCGGCCTAAC
TCCAGCGTCGAGAAACTGGCCACGCTGCGTCCGGTCTTCGGAGTGAAGGCCGGTGACGCGACGATGACGGCCGGCAATTC
GACTCCGCTGACCGACGGCGCCTCGGTGGCATTGCTGGCCAGCGAACAGTGGGCGGAGGCACACTCGCTGGCTCCGCTGG
CCTATCTCGTGGATGCCGAGACCGCCGCGGTCGACTATGTCAACGGCAACGACGGCCTGTTGATGGCGCCGACCTACGCG
GTACCCCGGCTGCTGGCCCGTAACGGGTTGAGCCTGCAGGACTTCGACTTCTACGAAATCCACGAGGCGTTTGCCTCCGT
GGTGCTCGCGCATCTGGCGGCGTGGGAGTCCGAGGAGTACTGCAAGCGGCGGCTGGGCCTGGACGCCGCGCTGGGGTCGA
TCGATCGGTCCAAGCTCAACGTCAACGGGTCGTCGTTGGCCGCCGGGCACCCCTTCGCGGCGACCGGTGGGCGGATTTTG
GCGCAGACCGCCAAGCAGCTCGCCGAGAAGAAGGCGGCGAAAAAAGGCGGCGGACCGCTGCGCGGGCTGATTTCGATCTG
CGCGGCCGGCGGCCAAGGTGTGGCCGCGATTTTGGAGGCCTGA

Upstream 100 bases:

>100_bases
TACACGTAACCGTATCGAGGACTAACTTACTTCAGAGTAAGAACAGTGGGTAGTATGGCCCTCAACGGCCGATCCCCCGA
ACTGATCAACGGAGAAAACA

Downstream 100 bases:

>100_bases
CGCTGACGGCTCGGTAAGTGCCTCGCGGGAAGTCCCGAGTGGCCGGTGGGCCGCCCAAAGAAATGTGTTGCGGGTGGTTT
GCGCCCTGAGCAGATGGGTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMREC
VLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLV
GTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPN
SSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYA
VPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRIL
AQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA

Sequences:

>Translated_440_residues
MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMREC
VLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLV
GTLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPN
SSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYA
VPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRIL
AQTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA
>Mature_439_residues
APAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLDMVVGGAVLKHSRDFNLMRECV
LGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEVAAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVG
TLPASLGVEIPANSEPRTGLSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPNS
SVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAETAAVDYVNGNDGLLMAPTYAV
PRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEYCKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILA
QTAKQLAEKKAAKKGGGPLRGLISICAAGGQGVAAILEA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=38.2488479262673, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI167614485, Length=439, Percent_Identity=30.0683371298405, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI148539872, Length=434, Percent_Identity=27.4193548387097, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4501853, Length=439, Percent_Identity=27.1070615034169, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557237, Length=437, Percent_Identity=25.858123569794, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1788683, Length=434, Percent_Identity=38.2488479262673, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082165, Length=438, Percent_Identity=29.6803652968037, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788554, Length=436, Percent_Identity=29.8165137614679, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787663, Length=439, Percent_Identity=28.9293849658314, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI48994986, Length=440, Percent_Identity=29.5454545454545, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=35.1851851851852, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI133906874, Length=436, Percent_Identity=27.9816513761468, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17535921, Length=439, Percent_Identity=27.1070615034169, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147385, Length=432, Percent_Identity=25, Blast_Score=128, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=447, Percent_Identity=28.4116331096197, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=439, Percent_Identity=25.9681093394077, Blast_Score=123, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17137578, Length=444, Percent_Identity=38.7387387387387, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17648125, Length=446, Percent_Identity=28.0269058295964, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24640423, Length=448, Percent_Identity=25.6696428571429, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24655093, Length=435, Percent_Identity=26.8965517241379, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46108; Mature: 45976

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLD
CCCCCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
MVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEV
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEE
AAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTG
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCEECCCCCCCCCC
LSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPN
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
SSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAE
CHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCHHHEEEECC
TAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEY
HHEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
CKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKGGGPL
HHHHHCHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
RGLISICAAGGQGVAAILEA
HHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure 
APAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLD
CCCCCCCHHHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
MVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEV
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCEEE
AAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTG
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCHHCCEECCCCCCCCCC
LSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPN
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
SSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAE
CHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCCHHHEEEECC
TAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEY
HHEEEEEECCCCEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
CKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKGGGPL
HHHHHCHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
RGLISICAAGGQGVAAILEA
HHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA