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The map label for this gene is fhs

Identifier: 148654152

GI number: 148654152

Start: 2933549

End: 2935258

Strand: Direct

Name: fhs

Synonym: PsycPRwf_2355

Alternate gene names: 148654152

Gene position: 2933549-2935258 (Clockwise)

Preceding gene: 148654151

Following gene: 148654153

Centisome position: 98.48

GC content: 49.53

Gene sequence:

>1710_bases
ATGACCGTCCCTAGTGATATTACTATTGCCCAAAATGCCACATTAAGACCTATTGTTGATATTGCTAAAAAAATAGGGCT
TTCAGCAGATAAGATTGAACCTTATGGCTATTACAAAGCCAAGATTAACCCAAATGATGTGTTTGATATGCCCGCTAAGT
CGAGCAATAGCAAACTGGTATTGGTCACCGCCATTAATCCCACCCCAGCCGGTGAAGGTAAGACCACCGTCACCATTGGG
CTGGCCGATGCGCTAAACCGTGTACATCATCAAGACCAAAACGGCAAACGTACTGTTGTGGCGCTACGTGAGCCGTCTGT
GGGTCCTGTGTTCGGCATTAAAGGCGGCGCAGCAGGGGGCGGCTATGCTCAAGTGTTGCCGATGGAGGATATCAATCTAC
ATTTCACTGGCGACTTGCATGCCATTGGTGCGGCCAACAACTTACTTGCCGCCCTAATCGATAACCATATTTATCAAGGC
AACGCGCTCAATATTGACCCAAAGCAAGTGGTGTGGCGCCGAGCGGTGGATATGAATGACCGTCAGCTGCGCAATACGGT
CACTGGTCTGGGCAAGCCTGCCGATGGGGTAATGCGCGAAGATGGCTTCGATATCACTGTGGCCTCAGAGGTCATGGCGA
TTTTTTGTTTGGCCACTGATTTGGCAGATTTAAAGCAGCGCTTGGGCAATATCTTAGTCGCTTATAACCAAGACAAGCAG
CCCATTTATGCTAAGGACCTCAAGGCTCATGGTGCCATGGCCGCCTTGTTAAAAGATGCCATTAAGCCAAACTTGGTACA
GACCATTGAGGGCACGCCAGCCATCTTACACGGTGGCCCTTTTGCCAATATCGCTCATGGCTGTAACTCGGTCATTGCCA
CCCGTACTGCCATGCATTTGGCCGATTACACACTCACAGAAGCAGGCTTCGGTGCTGACTTGGGTGCAGAGAAATTTTGT
GATATTAAATGCCGACTGGCCGGTCTTACCCCCGATGCAGCCGTGGTGGTCGCGACCATTCGTGCCCTTAAATATAATGG
TGGCGCGGCCAAAGATGCACTAAAAAATGAGGATCTAACTGCGCTTGAGCAAGGACTGCCCAATCTAACTAAACACATTG
AGAACCTACAAGAAGTATTCGGTCTGCCTGTGGTGGTCGCGATCAACCAATTTGAAAGCGACACGGCTGCTGAAATCGAG
ATGGTACGCAAAGCCTGTAAACGTCTAAAAGTAGAGGTGGCGTTAACTCAGGTGTGGGAAAAAGGCGGCGCCGGTGGCGA
GGATTTGGCCCGCACCTTGTTAGCGCTGTTAGAGACACATAACGATCAGCCGCAAACCTTTGGGTTTGCGTATGACAGTA
ACAAGCCTATTGTCAATAAAATACGCACTGTCGCCCAGCGCATTTATGGTGCCAATGATGTGGATATCAGTGTGACAGCG
GCAGCGAAGATTAAGCGATTAGAAGCGTTGGGGCTTGATAAAATGCCTATTTGTATCGCCAAGACTCAATACTCGCTCAG
CGATGACGCCAAGCTATTAGGGCGACCCACCGGCTTTAACATTCATGTGCGTGATATCAGTGTGTCTAACGGCGCCGGCT
TTATTGTGGTCATCTGTGGCCCTATCATGAAGATGCCCGGCCTACCAAAATACCCTTCTGCCGAAAACATTGATGTCGAT
GAGAAGGGGAACATTACCGGACTGTTTTAA

Upstream 100 bases:

>100_bases
AAATTAGCGGCTTTTATCACATATAAATAGCGCCTAATTATAAATAACTCCCAATATTTTTTGCTATCTTTAGATGACCC
TTTTTATTTGAGGCCTGATT

Downstream 100 bases:

>100_bases
CCATAACGGCTCCTGTTTATGCCTCCTCTTTGTGAAACCTATGAGCAGCACTTTGGTCTTTACCAATGTGCTGCTTTTTA
GTGATACAACCTAGTTTGCC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MTVPSDITIAQNATLRPIVDIAKKIGLSADKIEPYGYYKAKINPNDVFDMPAKSSNSKLVLVTAINPTPAGEGKTTVTIG
LADALNRVHHQDQNGKRTVVALREPSVGPVFGIKGGAAGGGYAQVLPMEDINLHFTGDLHAIGAANNLLAALIDNHIYQG
NALNIDPKQVVWRRAVDMNDRQLRNTVTGLGKPADGVMREDGFDITVASEVMAIFCLATDLADLKQRLGNILVAYNQDKQ
PIYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAILHGGPFANIAHGCNSVIATRTAMHLADYTLTEAGFGADLGAEKFC
DIKCRLAGLTPDAAVVVATIRALKYNGGAAKDALKNEDLTALEQGLPNLTKHIENLQEVFGLPVVVAINQFESDTAAEIE
MVRKACKRLKVEVALTQVWEKGGAGGEDLARTLLALLETHNDQPQTFGFAYDSNKPIVNKIRTVAQRIYGANDVDISVTA
AAKIKRLEALGLDKMPICIAKTQYSLSDDAKLLGRPTGFNIHVRDISVSNGAGFIVVICGPIMKMPGLPKYPSAENIDVD
EKGNITGLF

Sequences:

>Translated_569_residues
MTVPSDITIAQNATLRPIVDIAKKIGLSADKIEPYGYYKAKINPNDVFDMPAKSSNSKLVLVTAINPTPAGEGKTTVTIG
LADALNRVHHQDQNGKRTVVALREPSVGPVFGIKGGAAGGGYAQVLPMEDINLHFTGDLHAIGAANNLLAALIDNHIYQG
NALNIDPKQVVWRRAVDMNDRQLRNTVTGLGKPADGVMREDGFDITVASEVMAIFCLATDLADLKQRLGNILVAYNQDKQ
PIYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAILHGGPFANIAHGCNSVIATRTAMHLADYTLTEAGFGADLGAEKFC
DIKCRLAGLTPDAAVVVATIRALKYNGGAAKDALKNEDLTALEQGLPNLTKHIENLQEVFGLPVVVAINQFESDTAAEIE
MVRKACKRLKVEVALTQVWEKGGAGGEDLARTLLALLETHNDQPQTFGFAYDSNKPIVNKIRTVAQRIYGANDVDISVTA
AAKIKRLEALGLDKMPICIAKTQYSLSDDAKLLGRPTGFNIHVRDISVSNGAGFIVVICGPIMKMPGLPKYPSAENIDVD
EKGNITGLF
>Mature_568_residues
TVPSDITIAQNATLRPIVDIAKKIGLSADKIEPYGYYKAKINPNDVFDMPAKSSNSKLVLVTAINPTPAGEGKTTVTIGL
ADALNRVHHQDQNGKRTVVALREPSVGPVFGIKGGAAGGGYAQVLPMEDINLHFTGDLHAIGAANNLLAALIDNHIYQGN
ALNIDPKQVVWRRAVDMNDRQLRNTVTGLGKPADGVMREDGFDITVASEVMAIFCLATDLADLKQRLGNILVAYNQDKQP
IYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAILHGGPFANIAHGCNSVIATRTAMHLADYTLTEAGFGADLGAEKFCD
IKCRLAGLTPDAAVVVATIRALKYNGGAAKDALKNEDLTALEQGLPNLTKHIENLQEVFGLPVVVAINQFESDTAAEIEM
VRKACKRLKVEVALTQVWEKGGAGGEDLARTLLALLETHNDQPQTFGFAYDSNKPIVNKIRTVAQRIYGANDVDISVTAA
AKIKRLEALGLDKMPICIAKTQYSLSDDAKLLGRPTGFNIHVRDISVSNGAGFIVVICGPIMKMPGLPKYPSAENIDVDE
KGNITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=631, Percent_Identity=44.3740095087163, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI222136639, Length=631, Percent_Identity=41.838351822504, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=44.7058823529412, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=634, Percent_Identity=40.8517350157729, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568739, Length=634, Percent_Identity=40.8517350157729, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321643, Length=636, Percent_Identity=42.6100628930818, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319558, Length=643, Percent_Identity=41.3685847589425, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI62472483, Length=631, Percent_Identity=43.4231378763867, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45551871, Length=631, Percent_Identity=43.4231378763867, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24645718, Length=631, Percent_Identity=43.4231378763867, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI17137370, Length=631, Percent_Identity=43.4231378763867, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_PSYWF (A5WI04)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001281245.1
- ProteinModelPortal:   A5WI04
- SMR:   A5WI04
- STRING:   A5WI04
- GeneID:   5205124
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_2355
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- ProtClustDB:   PRK13505
- BioCyc:   PSP56811:PSYCPRWF_2355-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60835; Mature: 60703

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPSDITIAQNATLRPIVDIAKKIGLSADKIEPYGYYKAKINPNDVFDMPAKSSNSKLV
CCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
LVTAINPTPAGEGKTTVTIGLADALNRVHHQDQNGKRTVVALREPSVGPVFGIKGGAAGG
EEEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCCCCCC
GYAQVLPMEDINLHFTGDLHAIGAANNLLAALIDNHIYQGNALNIDPKQVVWRRAVDMND
CCEEEEEECCCEEEEECCEEEECCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCCH
RQLRNTVTGLGKPADGVMREDGFDITVASEVMAIFCLATDLADLKQRLGNILVAYNQDKQ
HHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PIYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAILHGGPFANIAHGCNSVIATRTAMHL
CCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
ADYTLTEAGFGADLGAEKFCDIKCRLAGLTPDAAVVVATIRALKYNGGAAKDALKNEDLT
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCHH
ALEQGLPNLTKHIENLQEVFGLPVVVAINQFESDTAAEIEMVRKACKRLKVEVALTQVWE
HHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGAGGEDLARTLLALLETHNDQPQTFGFAYDSNKPIVNKIRTVAQRIYGANDVDISVTA
HCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEH
AAKIKRLEALGLDKMPICIAKTQYSLSDDAKLLGRPTGFNIHVRDISVSNGAGFIVVICG
HHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEECCCCCEEEEEEC
PIMKMPGLPKYPSAENIDVDEKGNITGLF
HHHHCCCCCCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
TVPSDITIAQNATLRPIVDIAKKIGLSADKIEPYGYYKAKINPNDVFDMPAKSSNSKLV
CCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEE
LVTAINPTPAGEGKTTVTIGLADALNRVHHQDQNGKRTVVALREPSVGPVFGIKGGAAGG
EEEEECCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCCCCCC
GYAQVLPMEDINLHFTGDLHAIGAANNLLAALIDNHIYQGNALNIDPKQVVWRRAVDMND
CCEEEEEECCCEEEEECCEEEECCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCCH
RQLRNTVTGLGKPADGVMREDGFDITVASEVMAIFCLATDLADLKQRLGNILVAYNQDKQ
HHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
PIYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAILHGGPFANIAHGCNSVIATRTAMHL
CCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
ADYTLTEAGFGADLGAEKFCDIKCRLAGLTPDAAVVVATIRALKYNGGAAKDALKNEDLT
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCHH
ALEQGLPNLTKHIENLQEVFGLPVVVAINQFESDTAAEIEMVRKACKRLKVEVALTQVWE
HHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGAGGEDLARTLLALLETHNDQPQTFGFAYDSNKPIVNKIRTVAQRIYGANDVDISVTA
HCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEH
AAKIKRLEALGLDKMPICIAKTQYSLSDDAKLLGRPTGFNIHVRDISVSNGAGFIVVICG
HHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCCEEEEEEEEECCCCCEEEEEEC
PIMKMPGLPKYPSAENIDVDEKGNITGLF
HHHHCCCCCCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA