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The map label for this gene is nadR [H]

Identifier: 148654010

GI number: 148654010

Start: 2754502

End: 2755542

Strand: Direct

Name: nadR [H]

Synonym: PsycPRwf_2213

Alternate gene names: 148654010

Gene position: 2754502-2755542 (Clockwise)

Preceding gene: 148654003

Following gene: 148654011

Centisome position: 92.46

GC content: 46.11

Gene sequence:

>1041_bases
ATGCAAAAGTCAGGACTTATGATTGGTCACTTTGAACCGCTACATTTAGGTCATATTCGCAGTATTTTGCACGCCTCATC
TATGGTTGAGGTGCTTCACATTGTGATTACTCGCCACCCCAATCCCAATCAAAAGTTCCCGGTTACTTTGCAAGATAAGG
CACGCTGGTTACAGATGGCGTGTAGCGACTTACCTTTTATCAAAATTCACACCTGTGATGATTTTTCGTTCCCAGTTCAC
GACAGCATCGAGGACATTACGATTAATATCGATGGCTATAATGCCAAGATTGACTACATCCAAGATAAATTCAATATGGA
TGAGGACACCGTATTGTTGGTCACTGAAGGCCATCCACTGTCTAAGCCGTCAGTGACTTCTGCGCTAAACACCCAAGTGG
CCACTACCCCGCTACACCCTGAATTTGACAGTACCGCCATTCATTACAACCCCATTGCCAACTGGGATATTATTCATCCT
GAAGCGCGTGGCAACTATACCCGTACTGTCGCTATCGTTGGCGGTGAAAGCTCAGGTAAGACCACATTGTCACACAAGAT
TGCCAACTACTATGGCGCAGACTTAGTACTTGAAATGGGCCGTTTGTATGTGGGCACAGATTTGGGCGGTACTGAAGAGG
GGCTACAATACAGCGACTACGGACCCATTGCGTTAGACCACGCTCAAGCGGTGCGTGAGACCTTATATCAAGCTCAGTCA
CCGGTCACCATTGTTGATACCGATTTTGTCACCACTCAAGCTTTTTGTGAGGAATATGAGGGACGTACCCATCCGTTCGT
CACCGCCTGTATTGAGGAGTTTCGCTTCGATCATACCTTGTTTTTGGCCAATAACACCCCGTGGATAGATGATGGCATGC
GCTCTTTGGGTACCCCAAGCGCCAGAGATCGTTTTGAGAGCAGACTGACTGATATTTTTGCGCGTCATAATATCCAAACT
TATCGTATTGATAGTCCAGATTATTTTGCACGCTATGAGCAGGCCATTGCTTATATCGATCAACATATCTTTGGAAAGTA
G

Upstream 100 bases:

>100_bases
ACGTGACTAAAAACCCATAGATTTTTATCAAAAAAATATTAAGATAAGCTACATTAAATAAAAAAAATATTATCCAATTA
TCATTGTTAAGGAGCAGTAT

Downstream 100 bases:

>100_bases
GCCTGTTTATTGCGCCATAACATCCCGTACACTCAAAAAACCTTACCAGATGACGATAACTCAATCTCACCAATCACATA
ATTAGGACTGATATGCGTAT

Product: nicotinamide-nucleotide adenylyltransferase

Products: NA

Alternate protein names: Transcriptional regulator NadR; Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MQKSGLMIGHFEPLHLGHIRSILHASSMVEVLHIVITRHPNPNQKFPVTLQDKARWLQMACSDLPFIKIHTCDDFSFPVH
DSIEDITINIDGYNAKIDYIQDKFNMDEDTVLLVTEGHPLSKPSVTSALNTQVATTPLHPEFDSTAIHYNPIANWDIIHP
EARGNYTRTVAIVGGESSGKTTLSHKIANYYGADLVLEMGRLYVGTDLGGTEEGLQYSDYGPIALDHAQAVRETLYQAQS
PVTIVDTDFVTTQAFCEEYEGRTHPFVTACIEEFRFDHTLFLANNTPWIDDGMRSLGTPSARDRFESRLTDIFARHNIQT
YRIDSPDYFARYEQAIAYIDQHIFGK

Sequences:

>Translated_346_residues
MQKSGLMIGHFEPLHLGHIRSILHASSMVEVLHIVITRHPNPNQKFPVTLQDKARWLQMACSDLPFIKIHTCDDFSFPVH
DSIEDITINIDGYNAKIDYIQDKFNMDEDTVLLVTEGHPLSKPSVTSALNTQVATTPLHPEFDSTAIHYNPIANWDIIHP
EARGNYTRTVAIVGGESSGKTTLSHKIANYYGADLVLEMGRLYVGTDLGGTEEGLQYSDYGPIALDHAQAVRETLYQAQS
PVTIVDTDFVTTQAFCEEYEGRTHPFVTACIEEFRFDHTLFLANNTPWIDDGMRSLGTPSARDRFESRLTDIFARHNIQT
YRIDSPDYFARYEQAIAYIDQHIFGK
>Mature_346_residues
MQKSGLMIGHFEPLHLGHIRSILHASSMVEVLHIVITRHPNPNQKFPVTLQDKARWLQMACSDLPFIKIHTCDDFSFPVH
DSIEDITINIDGYNAKIDYIQDKFNMDEDTVLLVTEGHPLSKPSVTSALNTQVATTPLHPEFDSTAIHYNPIANWDIIHP
EARGNYTRTVAIVGGESSGKTTLSHKIANYYGADLVLEMGRLYVGTDLGGTEEGLQYSDYGPIALDHAQAVRETLYQAQS
PVTIVDTDFVTTQAFCEEYEGRTHPFVTACIEEFRFDHTLFLANNTPWIDDGMRSLGTPSARDRFESRLTDIFARHNIQT
YRIDSPDYFARYEQAIAYIDQHIFGK

Specific function: This enzyme has three activities:DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082440, Length=350, Percent_Identity=36.2857142857143, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR001387
- InterPro:   IPR010982
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01381 HTH_3 [H]

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 39108; Mature: 39108

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSGLMIGHFEPLHLGHIRSILHASSMVEVLHIVITRHPNPNQKFPVTLQDKARWLQMA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHH
CSDLPFIKIHTCDDFSFPVHDSIEDITINIDGYNAKIDYIQDKFNMDEDTVLLVTEGHPL
HCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCEEEEEECCCCC
SKPSVTSALNTQVATTPLHPEFDSTAIHYNPIANWDIIHPEARGNYTRTVAIVGGESSGK
CCCCHHHHHCCCEEECCCCCCCCCCEEEECCCCCCEEECCCCCCCEEEEEEEEECCCCCC
TTLSHKIANYYGADLVLEMGRLYVGTDLGGTEEGLQYSDYGPIALDHAQAVRETLYQAQS
HHHHHHHHHHHCHHHHHHHCCEEEECCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHCCC
PVTIVDTDFVTTQAFCEEYEGRTHPFVTACIEEFRFDHTLFLANNTPWIDDGMRSLGTPS
CEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCH
ARDRFESRLTDIFARHNIQTYRIDSPDYFARYEQAIAYIDQHIFGK
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKSGLMIGHFEPLHLGHIRSILHASSMVEVLHIVITRHPNPNQKFPVTLQDKARWLQMA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHH
CSDLPFIKIHTCDDFSFPVHDSIEDITINIDGYNAKIDYIQDKFNMDEDTVLLVTEGHPL
HCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEHHCCCCCCCEEEEEECCCCC
SKPSVTSALNTQVATTPLHPEFDSTAIHYNPIANWDIIHPEARGNYTRTVAIVGGESSGK
CCCCHHHHHCCCEEECCCCCCCCCCEEEECCCCCCEEECCCCCCCEEEEEEEEECCCCCC
TTLSHKIANYYGADLVLEMGRLYVGTDLGGTEEGLQYSDYGPIALDHAQAVRETLYQAQS
HHHHHHHHHHHCHHHHHHHCCEEEECCCCCCCCCCEECCCCCEEEHHHHHHHHHHHHCCC
PVTIVDTDFVTTQAFCEEYEGRTHPFVTACIEEFRFDHTLFLANNTPWIDDGMRSLGTPS
CEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCH
ARDRFESRLTDIFARHNIQTYRIDSPDYFARYEQAIAYIDQHIFGK
HHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 1327967 [H]