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The map label for this gene is purC

Identifier: 148653923

GI number: 148653923

Start: 2651472

End: 2652191

Strand: Direct

Name: purC

Synonym: PsycPRwf_2126

Alternate gene names: 148653923

Gene position: 2651472-2652191 (Clockwise)

Preceding gene: 148653922

Following gene: 148653924

Centisome position: 89.01

GC content: 43.33

Gene sequence:

>720_bases
ATGCAGCTTCAAAAACAAGACCTCCTTTACAAAGGCAAAGCCAAATCTGTTTATGAAACAGAGAACTCTGATTATCTGAT
ACTTCATTTCCGTGATGACACCTCAGCTTTTAACGGTGAGCGCATCGAACAGTTAGGCCGTAAAGGACAAGTGAATAACC
GCTTCAATGCGTTTATCATGCAAAAGCTTGCTGAAGCCGGTATTGAAACTCATTTTGAAAAACAGCTTTCTGATGATGAA
GTATTGGTAAAACGCCTAGAGATGATTCCTGTAGAGTGTGTGGTACGTAACTTTGCTGCCGGCAGCTTAGTACGCCGCTT
AGGTCTAGAAGAAGGACAGCCTCTTACACCACCCACTTATGAGCTGTTTTTCAAAGATGATGCGCTAGGTGACCCTATGG
TTAACGAATCATTGTCTGTATCTTTAGGCTGGGCGACACCTGAGCAATTAGCAAAAATGAAAGAGCTTACCTTCAAGGTT
AATGACGTGCTAAAAGAGCTGTTTGATGCAGGCGGTTTGATGTTGGTTGATTTCAAACTTGAATTTGGTGTGTTCCAAGA
CCGCATCGTATTAGGGGATGAGTTCTCTCCAGATGGCTGCCGTATTTGGGACAAAGAAACCAAGAAAAAACTAGACAAAG
ACCGTTTCCGTCAGAGCCTAGGCGACGTTATCGAGTCTTATGAAGAAGTGGCTCAACGTATCGGCGTTCCAATGAACTAA

Upstream 100 bases:

>100_bases
TGCGCCCAGTCGCGCGATTGGTTGCACTCACATTACCCTTTTCAACCCCCTCTTAGCTAAGATACTTATCCCACTTAGCT
ATTTGCATAGGACTTAAATC

Downstream 100 bases:

>100_bases
AAATGACTGCTAATGTGTAAAAAAGGCCGACTATGAGTAATTTATAGTCGGCCTTTTTTTCGCCTTGCACTGTGTGGGGG
CTTCTATAGTTAACAACCCC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQLQKQDLLYKGKAKSVYETENSDYLILHFRDDTSAFNGERIEQLGRKGQVNNRFNAFIMQKLAEAGIETHFEKQLSDDE
VLVKRLEMIPVECVVRNFAAGSLVRRLGLEEGQPLTPPTYELFFKDDALGDPMVNESLSVSLGWATPEQLAKMKELTFKV
NDVLKELFDAGGLMLVDFKLEFGVFQDRIVLGDEFSPDGCRIWDKETKKKLDKDRFRQSLGDVIESYEEVAQRIGVPMN

Sequences:

>Translated_239_residues
MQLQKQDLLYKGKAKSVYETENSDYLILHFRDDTSAFNGERIEQLGRKGQVNNRFNAFIMQKLAEAGIETHFEKQLSDDE
VLVKRLEMIPVECVVRNFAAGSLVRRLGLEEGQPLTPPTYELFFKDDALGDPMVNESLSVSLGWATPEQLAKMKELTFKV
NDVLKELFDAGGLMLVDFKLEFGVFQDRIVLGDEFSPDGCRIWDKETKKKLDKDRFRQSLGDVIESYEEVAQRIGVPMN
>Mature_239_residues
MQLQKQDLLYKGKAKSVYETENSDYLILHFRDDTSAFNGERIEQLGRKGQVNNRFNAFIMQKLAEAGIETHFEKQLSDDE
VLVKRLEMIPVECVVRNFAAGSLVRRLGLEEGQPLTPPTYELFFKDDALGDPMVNESLSVSLGWATPEQLAKMKELTFKV
NDVLKELFDAGGLMLVDFKLEFGVFQDRIVLGDEFSPDGCRIWDKETKKKLDKDRFRQSLGDVIESYEEVAQRIGVPMN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=244, Percent_Identity=33.1967213114754, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI5453539, Length=244, Percent_Identity=33.1967213114754, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI119220559, Length=251, Percent_Identity=31.8725099601594, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=66.6666666666667, Blast_Score=331, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17531275, Length=241, Percent_Identity=31.1203319502075, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18860083, Length=235, Percent_Identity=30.6382978723404, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583917, Length=235, Percent_Identity=28.936170212766, Blast_Score=98, Evalue=4e-21,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PSYWF (A5WHC5)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001281016.1
- ProteinModelPortal:   A5WHC5
- SMR:   A5WHC5
- STRING:   A5WHC5
- GeneID:   5205417
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_2126
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   PSP56811:PSYCPRWF_2126-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27338; Mature: 27338

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLQKQDLLYKGKAKSVYETENSDYLILHFRDDTSAFNGERIEQLGRKGQVNNRFNAFIM
CCCCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHH
QKLAEAGIETHFEKQLSDDEVLVKRLEMIPVECVVRNFAAGSLVRRLGLEEGQPLTPPTY
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
ELFFKDDALGDPMVNESLSVSLGWATPEQLAKMKELTFKVNDVLKELFDAGGLMLVDFKL
EEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
EFGVFQDRIVLGDEFSPDGCRIWDKETKKKLDKDRFRQSLGDVIESYEEVAQRIGVPMN
CCCCCCCEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQLQKQDLLYKGKAKSVYETENSDYLILHFRDDTSAFNGERIEQLGRKGQVNNRFNAFIM
CCCCHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHH
QKLAEAGIETHFEKQLSDDEVLVKRLEMIPVECVVRNFAAGSLVRRLGLEEGQPLTPPTY
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
ELFFKDDALGDPMVNESLSVSLGWATPEQLAKMKELTFKVNDVLKELFDAGGLMLVDFKL
EEEECCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
EFGVFQDRIVLGDEFSPDGCRIWDKETKKKLDKDRFRQSLGDVIESYEEVAQRIGVPMN
CCCCCCCEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA