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The map label for this gene is pth [H]

Identifier: 148653904

GI number: 148653904

Start: 2629686

End: 2630309

Strand: Direct

Name: pth [H]

Synonym: PsycPRwf_2107

Alternate gene names: 148653904

Gene position: 2629686-2630309 (Clockwise)

Preceding gene: 148653903

Following gene: 148653905

Centisome position: 88.27

GC content: 44.55

Gene sequence:

>624_bases
ATGGGTGGCCCTCCTTACTTACTAGACAGTGAGAACGCTATGTCCCAACTTAAACTTATTGTTGGGCTTGGCAACCCAGG
TCAGCAGTATGTCGAAACCCGACATAATGCTGGCTTTTGGTTTGTGGCCCTGATTGCCGATCAATTTAATATTGAATTGG
CAGCTGACAAGAAGTTCAATGGCTTAACCGGACGCGGACGTATCTTTGGTACCGATGTTCGCCTGTTGTTGCCGATGACT
TTTATGAATAAGTCAGGTCAATCGGTTGTGCCTATGGCGAAATACTATGACATTAAACCTGAAGAGCTCCTTATCGCTCA
TGATGAGCTTGATATTGCGGCAGGTAGTATTAAGCTAAAAACTGGCGGTGGTCATGGCGGTCATAATGGCCTACGTGATA
TCACGCCCCATTTAGGCAATGACTTTCACCGCTTACGTATAGGCATTGGCCATCCCGGTCATAAATCTAAAGTAAGTGGC
CATGTCCTATCTAAACCCTCTCCTGAAGATCAAATTGCTATTGAAGCTGCTTTAGACGCCGCTATGTCCTCATTAAAGTT
GATGGTAACTGGCGATATTGAAAAAGCACGCAGTCAAATTAATGGCTTTAAACTTCCCAATTGA

Upstream 100 bases:

>100_bases
ACGCAGCTGACGTTCCAGCTACCGAACAAGGTAGTGAAGAAGACAAAGGCGAATAATTTTCGCCCGCCACTCACAACCGA
TACGCCTTGTGCTATCAGTT

Downstream 100 bases:

>100_bases
TAGACATTAACTTAAGGCGGCTATTGATTTTTTGATATTTGCCGCTATTAAGTTACTACCCCCGTCTGTATTTTTCTTTT
TGCTAATTTATTCAAAAAAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MGGPPYLLDSENAMSQLKLIVGLGNPGQQYVETRHNAGFWFVALIADQFNIELAADKKFNGLTGRGRIFGTDVRLLLPMT
FMNKSGQSVVPMAKYYDIKPEELLIAHDELDIAAGSIKLKTGGGHGGHNGLRDITPHLGNDFHRLRIGIGHPGHKSKVSG
HVLSKPSPEDQIAIEAALDAAMSSLKLMVTGDIEKARSQINGFKLPN

Sequences:

>Translated_207_residues
MGGPPYLLDSENAMSQLKLIVGLGNPGQQYVETRHNAGFWFVALIADQFNIELAADKKFNGLTGRGRIFGTDVRLLLPMT
FMNKSGQSVVPMAKYYDIKPEELLIAHDELDIAAGSIKLKTGGGHGGHNGLRDITPHLGNDFHRLRIGIGHPGHKSKVSG
HVLSKPSPEDQIAIEAALDAAMSSLKLMVTGDIEKARSQINGFKLPN
>Mature_206_residues
GGPPYLLDSENAMSQLKLIVGLGNPGQQYVETRHNAGFWFVALIADQFNIELAADKKFNGLTGRGRIFGTDVRLLLPMTF
MNKSGQSVVPMAKYYDIKPEELLIAHDELDIAAGSIKLKTGGGHGGHNGLRDITPHLGNDFHRLRIGIGHPGHKSKVSGH
VLSKPSPEDQIAIEAALDAAMSSLKLMVTGDIEKARSQINGFKLPN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=166, Percent_Identity=34.9397590361446, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=53.1578947368421, Blast_Score=179, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321983, Length=183, Percent_Identity=28.4153005464481, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22389; Mature: 22258

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGPPYLLDSENAMSQLKLIVGLGNPGQQYVETRHNAGFWFVALIADQFNIELAADKKFN
CCCCCCEEECCCHHHEEEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCC
GLTGRGRIFGTDVRLLLPMTFMNKSGQSVVPMAKYYDIKPEELLIAHDELDIAAGSIKLK
CCCCCCEEEECCCEEEEEHHHHCCCCCEECCHHHHCCCCCHHEEEEECCCEEEECEEEEE
TGGGHGGHNGLRDITPHLGNDFHRLRIGIGHPGHKSKVSGHVLSKPSPEDQIAIEAALDA
ECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
AMSSLKLMVTGDIEKARSQINGFKLPN
HHHHEEEEEECCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GGPPYLLDSENAMSQLKLIVGLGNPGQQYVETRHNAGFWFVALIADQFNIELAADKKFN
CCCCCEEECCCHHHEEEEEEECCCCHHHHHHHCCCCCEEEEEEEECCCEEEEEECCCCC
GLTGRGRIFGTDVRLLLPMTFMNKSGQSVVPMAKYYDIKPEELLIAHDELDIAAGSIKLK
CCCCCCEEEECCCEEEEEHHHHCCCCCEECCHHHHCCCCCHHEEEEECCCEEEECEEEEE
TGGGHGGHNGLRDITPHLGNDFHRLRIGIGHPGHKSKVSGHVLSKPSPEDQIAIEAALDA
ECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHH
AMSSLKLMVTGDIEKARSQINGFKLPN
HHHHEEEEEECCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA