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The map label for this gene is proA

Identifier: 148653876

GI number: 148653876

Start: 2592478

End: 2593776

Strand: Direct

Name: proA

Synonym: PsycPRwf_2079

Alternate gene names: 148653876

Gene position: 2592478-2593776 (Clockwise)

Preceding gene: 148653866

Following gene: 148653877

Centisome position: 87.03

GC content: 48.27

Gene sequence:

>1299_bases
ATGACACAAGCCATCAGTGATATAAAAGCCTATATGCAGCAAGTTGGTAAACACGCAAGAGATGCCTCAAGACAGTTAGC
CGCCGCTAATACCGGTGACAAAAATGCCGCTTTGTTAATTATTTATGAGCAATTAAAACAGGCCAAAGACGAAATATTAG
CCGCCAATAAAATCGATATGGACAAGGGCCGAAGCAACAACTTAGATGCCGCCCTACTTGACCGCTTGGCACTTAATGAA
TCTCGCTTTGAGGCGATGCTACAAGGCCTAAAAGATGTGGCCGCTTTGCCTGACCCTATTGGTGAAGTCACTGACATGAC
TTACCGTCCTTCTGGTATTCAGCTGGGTAAAATGCGGGTCCCTTTGGGCGTGGTGGGCATGATTTATGAGTCTCGTCCCA
ATGTGACGTTAGAGGCCGCTTCTTTGGCACTAAAATCTGGCAATGCCATTATTTTACGCGGCGGCTCAGAAGCTTATGAA
TCAAACCAAGCGATTGCCAAATATATCTTATCTGGTCTAAAACAGGCCGGTCTGCCTGAGCACGGTGTTCAGGTGTTACA
GACCACAGACCGCGCCGCAGTGGGAGAGCTGATTACCTTAACAGAATATGTCGATGTGATTGTGCCACGTGGCGGCAAGG
GCCTTATTGCCCGTATTAGCCAAGATGCGCGCGTGCCGGTTATTAAGCATTTAGATGGCAACTGCCACACCTTTATTGAC
AGTGATGCCGACCCTGAGATTGCTATTAAGGTCAGTGTTAATGCCAAGACGCATCGCTACGGCACCTGTAATACCATGGA
AACCTTATTGGTAGATCAAGCGATTGCTAATGAGCTGTTACCTCAGATAGCCGAGGCCATTGTCGCAGCCGATGACGCCA
TGCAGCTTCGCTTAGATGCCGCCTCAAGAACCATTTTACAAGACAATGCTAAGCTTGGCGGCCACTTAAGTGACGCCACA
GATAGCGACTGGGATACCGAATACTTAGCACCCATCTTAGCGGTCAAAATTATAGACGGCTTAGATGCCGCCATTGACCA
CATCAATACCCATGGCAGCCATCACACTGATGTGATTATCACTAATAACTATAGTAAGTCGCAGCGCTTCATTCGCGAAG
TGGACTCAGCCAGTGTGATGATTAACGCCTCAAGCCGCTTTGCAGATGGCTTTGAATATGGCTTGGGTGCTGAAATTGGC
ATCTCAACTGACAAAATCCATGCCCGTGGCCCCGTCGGACTCAATGGCCTTACCTCTCAAAAATGGATTGTCTATGGTCA
TGGCGAGGTGCGTAGCTAG

Upstream 100 bases:

>100_bases
GTCACTTTACTATTAGCGACATCTGCTTTATGTTAAACCTCATCTTATTTTTATAAAAAACAACCCCAATCAATAAGCAA
AAAAGCATCAGGAGACAACA

Downstream 100 bases:

>100_bases
GCTAGGATTGCCTCGCTCCTTGGCTCAAGGTGGCCATTTTTGGGAGTAATTTGTTTGATAAAAGTGATTATGTTAATCAA
ATACCATCAGACCCTCTATC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTQAISDIKAYMQQVGKHARDASRQLAAANTGDKNAALLIIYEQLKQAKDEILAANKIDMDKGRSNNLDAALLDRLALNE
SRFEAMLQGLKDVAALPDPIGEVTDMTYRPSGIQLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAYE
SNQAIAKYILSGLKQAGLPEHGVQVLQTTDRAAVGELITLTEYVDVIVPRGGKGLIARISQDARVPVIKHLDGNCHTFID
SDADPEIAIKVSVNAKTHRYGTCNTMETLLVDQAIANELLPQIAEAIVAADDAMQLRLDAASRTILQDNAKLGGHLSDAT
DSDWDTEYLAPILAVKIIDGLDAAIDHINTHGSHHTDVIITNNYSKSQRFIREVDSASVMINASSRFADGFEYGLGAEIG
ISTDKIHARGPVGLNGLTSQKWIVYGHGEVRS

Sequences:

>Translated_432_residues
MTQAISDIKAYMQQVGKHARDASRQLAAANTGDKNAALLIIYEQLKQAKDEILAANKIDMDKGRSNNLDAALLDRLALNE
SRFEAMLQGLKDVAALPDPIGEVTDMTYRPSGIQLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAYE
SNQAIAKYILSGLKQAGLPEHGVQVLQTTDRAAVGELITLTEYVDVIVPRGGKGLIARISQDARVPVIKHLDGNCHTFID
SDADPEIAIKVSVNAKTHRYGTCNTMETLLVDQAIANELLPQIAEAIVAADDAMQLRLDAASRTILQDNAKLGGHLSDAT
DSDWDTEYLAPILAVKIIDGLDAAIDHINTHGSHHTDVIITNNYSKSQRFIREVDSASVMINASSRFADGFEYGLGAEIG
ISTDKIHARGPVGLNGLTSQKWIVYGHGEVRS
>Mature_431_residues
TQAISDIKAYMQQVGKHARDASRQLAAANTGDKNAALLIIYEQLKQAKDEILAANKIDMDKGRSNNLDAALLDRLALNES
RFEAMLQGLKDVAALPDPIGEVTDMTYRPSGIQLGKMRVPLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAYES
NQAIAKYILSGLKQAGLPEHGVQVLQTTDRAAVGELITLTEYVDVIVPRGGKGLIARISQDARVPVIKHLDGNCHTFIDS
DADPEIAIKVSVNAKTHRYGTCNTMETLLVDQAIANELLPQIAEAIVAADDAMQLRLDAASRTILQDNAKLGGHLSDATD
SDWDTEYLAPILAVKIIDGLDAAIDHINTHGSHHTDVIITNNYSKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGI
STDKIHARGPVGLNGLTSQKWIVYGHGEVRS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=428, Percent_Identity=36.4485981308411, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI21361368, Length=427, Percent_Identity=36.2997658079625, Blast_Score=255, Evalue=4e-68,
Organism=Escherichia coli, GI1786438, Length=421, Percent_Identity=43.2304038004751, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17569967, Length=427, Percent_Identity=34.192037470726, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17569969, Length=427, Percent_Identity=34.192037470726, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=436, Percent_Identity=38.9908256880734, Blast_Score=296, Evalue=4e-81,
Organism=Drosophila melanogaster, GI21357643, Length=420, Percent_Identity=35.7142857142857, Blast_Score=261, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PSYWF (A5WH78)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001280969.1
- ProteinModelPortal:   A5WH78
- SMR:   A5WH78
- STRING:   A5WH78
- GeneID:   5205203
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_2079
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- ProtClustDB:   PRK00197
- BioCyc:   PSP56811:PSYCPRWF_2079-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46525; Mature: 46394

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAISDIKAYMQQVGKHARDASRQLAAANTGDKNAALLIIYEQLKQAKDEILAANKIDM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCC
DKGRSNNLDAALLDRLALNESRFEAMLQGLKDVAALPDPIGEVTDMTYRPSGIQLGKMRV
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCCCCEECEEEC
PLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAYESNQAIAKYILSGLKQAGLPE
CHHHEEHEEECCCCEEEEEHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCH
HGVQVLQTTDRAAVGELITLTEYVDVIVPRGGKGLIARISQDARVPVIKHLDGNCHTFID
HHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCEECCCCEEEEEC
SDADPEIAIKVSVNAKTHRYGTCNTMETLLVDQAIANELLPQIAEAIVAADDAMQLRLDA
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHH
ASRTILQDNAKLGGHLSDATDSDWDTEYLAPILAVKIIDGLDAAIDHINTHGSHHTDVII
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TNNYSKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGISTDKIHARGPVGLNGLTSQ
ECCCHHHHHHHHHCCCCEEEEECCCCCCCCHHCCCCCEECCCCCCEECCCCCCCCCCCCC
KWIVYGHGEVRS
CEEEEECCCCCC
>Mature Secondary Structure 
TQAISDIKAYMQQVGKHARDASRQLAAANTGDKNAALLIIYEQLKQAKDEILAANKIDM
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCC
DKGRSNNLDAALLDRLALNESRFEAMLQGLKDVAALPDPIGEVTDMTYRPSGIQLGKMRV
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCCCEECCCCCEECEEEC
PLGVVGMIYESRPNVTLEAASLALKSGNAIILRGGSEAYESNQAIAKYILSGLKQAGLPE
CHHHEEHEEECCCCEEEEEHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCH
HGVQVLQTTDRAAVGELITLTEYVDVIVPRGGKGLIARISQDARVPVIKHLDGNCHTFID
HHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCEECCCCEEEEEC
SDADPEIAIKVSVNAKTHRYGTCNTMETLLVDQAIANELLPQIAEAIVAADDAMQLRLDA
CCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHH
ASRTILQDNAKLGGHLSDATDSDWDTEYLAPILAVKIIDGLDAAIDHINTHGSHHTDVII
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
TNNYSKSQRFIREVDSASVMINASSRFADGFEYGLGAEIGISTDKIHARGPVGLNGLTSQ
ECCCHHHHHHHHHCCCCEEEEECCCCCCCCHHCCCCCEECCCCCCEECCCCCCCCCCCCC
KWIVYGHGEVRS
CEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA