Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 148653801

GI number: 148653801

Start: 2494634

End: 2495989

Strand: Direct

Name: gor [H]

Synonym: PsycPRwf_2004

Alternate gene names: 148653801

Gene position: 2494634-2495989 (Clockwise)

Preceding gene: 148653800

Following gene: 148653803

Centisome position: 83.74

GC content: 45.21

Gene sequence:

>1356_bases
ATGAGTAGACATTACGACTATATCGCTATTGGGGGCGGTAGCGGCGGTATCGCCTCTATTAACCGCGCGGCCATGTATGG
CAAAAAATGTGCCATTATTGAAGCCAATCACTTAGGCGGCACCTGTGTAAACTTAGGCTGCGTTCCAAAAAAAGTGATGT
GGTATGGCGCCCAAGTGGCCGAGGCCATGCACAAATATGCGCCAGATTATGGTTTTGATGTCGAAGTAAAAGGCTTTGAC
TTTAATAAGCTTGTTGAGACCCGCCAAAAATATATTGCCAATATCCACCGCTCTTATGAGAATAATTTGGCCAAAAATAA
CGTAGAGGTCATCAATGGCTTTGCCAAATTCGTCGATAGCAAAACCGTCGAAGTCAATGGTGAGCACATTACTGCCGATC
ATATCTTAATTGCTACCGGCGGCCGCCCTATCTATCCAGATATTAAAGGCGCTGAGTACGGTATAGACTCTGATGGCTTC
TTTGCTTTGCAACAGCTTCCTAAACGAGTGGCTGTCGTCGGTGCAGGTTATATTGCTGTTGAGATAACAGGCGTGTTGCG
CAGCTTAGGGTCAGAAGTCGATTTATACGTTCGCCAGCATTCTCCTTTGCGCTCTTTTGACCACAGCATCGTTAATGTCT
TGCTTGAAGAGATGGCCAAAGAAGGCATCGAGTTACACACCCATACGGTGATTAAACAGATTGTTAAAAATGAAGATGGC
AGTCTTACTATAGAATTAGAAGATGGTCGCATAAATACTGTAGACTGCCTAATTTGGGCGGTGGGCCGCGAGCCTGCTAC
CGATAAGATTAACTTGGAAGTGACTGGGGTTGAGACCAATTCTATCGGTAAAATCAAAGTTGATAAGTTCCAAAATACCA
ATGTGGCAGGCATTTATGCCGTTGGTGATATTATCGAAAACAGTATCGACCTAACCCCTGTGGCCATAGCTGCCGGTCGC
CGCTTATCTGAACGTTTGTTTAACAATAAGCCAAATGAACATCTTGATTATAGCTTAGTGCCCACAGTGATTTTCACTCA
CCCCCCTATTGGCACTATTGGTATGTCTGAGATGCAGGCCATTGAGCAATATGGTGAAGACGCTATCAAATGCTACACCT
CAAGCTTTACCCCGATGTATAGCGCTGTAACTCAGCACCGCCAAAAATGCACCATGAAGCTGGTATGCTTAGGTGACGAA
GAAAAAGTCATTGGCTTACATGGCATTGGCTTTGGTGTCGATGAAATGATTCAAGGTTTTGCGGTCGCTATCAAGATGGG
GGCTACCAAGGCTGATTTCGATAATACGGTTGCCATCCATCCTACCGGCTCTGAAGAATTTGTGACGATGCGATAA

Upstream 100 bases:

>100_bases
TTTGGATAAAAATCAACGCCAATAACCGTTACAATTATCCGCATCTTGTAAAGTGTTAGTACTGTTAAATTAATACACAC
CAATAAAAAAAGGATCCGTT

Downstream 100 bases:

>100_bases
GTCATTACTATTTTGGGCATTGGTTACTGTTTTATATTTTAGGACGGGACAGCCTACAAAAAAAGGCCACTCTATTTTAG
AGTGGCCTTTTGCTATGCTC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSRHYDYIAIGGGSGGIASINRAAMYGKKCAIIEANHLGGTCVNLGCVPKKVMWYGAQVAEAMHKYAPDYGFDVEVKGFD
FNKLVETRQKYIANIHRSYENNLAKNNVEVINGFAKFVDSKTVEVNGEHITADHILIATGGRPIYPDIKGAEYGIDSDGF
FALQQLPKRVAVVGAGYIAVEITGVLRSLGSEVDLYVRQHSPLRSFDHSIVNVLLEEMAKEGIELHTHTVIKQIVKNEDG
SLTIELEDGRINTVDCLIWAVGREPATDKINLEVTGVETNSIGKIKVDKFQNTNVAGIYAVGDIIENSIDLTPVAIAAGR
RLSERLFNNKPNEHLDYSLVPTVIFTHPPIGTIGMSEMQAIEQYGEDAIKCYTSSFTPMYSAVTQHRQKCTMKLVCLGDE
EKVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_451_residues
MSRHYDYIAIGGGSGGIASINRAAMYGKKCAIIEANHLGGTCVNLGCVPKKVMWYGAQVAEAMHKYAPDYGFDVEVKGFD
FNKLVETRQKYIANIHRSYENNLAKNNVEVINGFAKFVDSKTVEVNGEHITADHILIATGGRPIYPDIKGAEYGIDSDGF
FALQQLPKRVAVVGAGYIAVEITGVLRSLGSEVDLYVRQHSPLRSFDHSIVNVLLEEMAKEGIELHTHTVIKQIVKNEDG
SLTIELEDGRINTVDCLIWAVGREPATDKINLEVTGVETNSIGKIKVDKFQNTNVAGIYAVGDIIENSIDLTPVAIAAGR
RLSERLFNNKPNEHLDYSLVPTVIFTHPPIGTIGMSEMQAIEQYGEDAIKCYTSSFTPMYSAVTQHRQKCTMKLVCLGDE
EKVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_450_residues
SRHYDYIAIGGGSGGIASINRAAMYGKKCAIIEANHLGGTCVNLGCVPKKVMWYGAQVAEAMHKYAPDYGFDVEVKGFDF
NKLVETRQKYIANIHRSYENNLAKNNVEVINGFAKFVDSKTVEVNGEHITADHILIATGGRPIYPDIKGAEYGIDSDGFF
ALQQLPKRVAVVGAGYIAVEITGVLRSLGSEVDLYVRQHSPLRSFDHSIVNVLLEEMAKEGIELHTHTVIKQIVKNEDGS
LTIELEDGRINTVDCLIWAVGREPATDKINLEVTGVETNSIGKIKVDKFQNTNVAGIYAVGDIIENSIDLTPVAIAAGRR
LSERLFNNKPNEHLDYSLVPTVIFTHPPIGTIGMSEMQAIEQYGEDAIKCYTSSFTPMYSAVTQHRQKCTMKLVCLGDEE
KVIGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=52.9284164859002, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=38.6075949367089, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=37.9084967320261, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI148277071, Length=459, Percent_Identity=37.9084967320261, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=37.4727668845316, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=37.4727668845316, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=37.4727668845316, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=35, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI291045268, Length=460, Percent_Identity=31.9565217391304, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=29.247311827957, Blast_Score=169, Evalue=7e-42,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=70.9534368070953, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=448, Percent_Identity=28.7946428571429, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=27.292576419214, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=25.60706401766, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=52.3281596452328, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=52.3281596452328, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=36.0169491525424, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=35.625, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI32565766, Length=468, Percent_Identity=30.1282051282051, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=48.7124463519313, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=27.5053304904051, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=23.4672304439746, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640549, Length=473, Percent_Identity=40.169133192389, Blast_Score=296, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24640553, Length=473, Percent_Identity=40.169133192389, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=40.169133192389, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=37.7118644067797, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=28.6937901498929, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49378; Mature: 49247

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHYDYIAIGGGSGGIASINRAAMYGKKCAIIEANHLGGTCVNLGCVPKKVMWYGAQVA
CCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAMHKYAPDYGFDVEVKGFDFNKLVETRQKYIANIHRSYENNLAKNNVEVINGFAKFVDS
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
KTVEVNGEHITADHILIATGGRPIYPDIKGAEYGIDSDGFFALQQLPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCEEEE
EITGVLRSLGSEVDLYVRQHSPLRSFDHSIVNVLLEEMAKEGIELHTHTVIKQIVKNEDG
EHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCC
SLTIELEDGRINTVDCLIWAVGREPATDKINLEVTGVETNSIGKIKVDKFQNTNVAGIYA
EEEEEECCCCCCEEEEEEEEECCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCEEEEEE
VGDIIENSIDLTPVAIAAGRRLSERLFNNKPNEHLDYSLVPTVIFTHPPIGTIGMSEMQA
EHHHHHCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCCHHHHHH
IEQYGEDAIKCYTSSFTPMYSAVTQHRQKCTMKLVCLGDEEKVIGLHGIGFGVDEMIQGF
HHHHCCHHEEHHHCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
SRHYDYIAIGGGSGGIASINRAAMYGKKCAIIEANHLGGTCVNLGCVPKKVMWYGAQVA
CCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAMHKYAPDYGFDVEVKGFDFNKLVETRQKYIANIHRSYENNLAKNNVEVINGFAKFVDS
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
KTVEVNGEHITADHILIATGGRPIYPDIKGAEYGIDSDGFFALQQLPKRVAVVGAGYIAV
CEEEECCCEEEECEEEEEECCEECCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCEEEE
EITGVLRSLGSEVDLYVRQHSPLRSFDHSIVNVLLEEMAKEGIELHTHTVIKQIVKNEDG
EHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCC
SLTIELEDGRINTVDCLIWAVGREPATDKINLEVTGVETNSIGKIKVDKFQNTNVAGIYA
EEEEEECCCCCCEEEEEEEEECCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCEEEEEE
VGDIIENSIDLTPVAIAAGRRLSERLFNNKPNEHLDYSLVPTVIFTHPPIGTIGMSEMQA
EHHHHHCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCCEEECEEEEECCCCCCCCHHHHHH
IEQYGEDAIKCYTSSFTPMYSAVTQHRQKCTMKLVCLGDEEKVIGLHGIGFGVDEMIQGF
HHHHCCHHEEHHHCCCCHHHHHHHHHHHHCEEEEEEECCCCCEEEEEECCCCHHHHHHHH
AVAIKMGATKADFDNTVAIHPTGSEEFVTMR
EEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]