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The map label for this gene is lip2 [H]

Identifier: 148653796

GI number: 148653796

Start: 2489857

End: 2490915

Strand: Direct

Name: lip2 [H]

Synonym: PsycPRwf_1999

Alternate gene names: 148653796

Gene position: 2489857-2490915 (Clockwise)

Preceding gene: 148653794

Following gene: 148653797

Centisome position: 83.58

GC content: 50.24

Gene sequence:

>1059_bases
ATGACTATTATTAATAAATCCAACCTCCATCAGCTGAGTACAAAAACCCGCAATGCCTTGATGAAAAGCGTGGTGCGCTT
GCCGACAGCAGCCAAACAACAGATAGCAGGTGAGCCTATTGTCATTGATGGGCAAACCTTTGATTTATCCCTACAAGTGA
TGCTACAGCTGTTCGGTCCACCGCCCAATCATCTGCCCAGTGTCACAGAAGCTCGAGCAACCATTGAGGCGCAAAGCCCT
GTGCTCAGTCAGACACCTCTGGACGATATTATCAAAGATGAGTTCCCACTAACGGTATCTGATGGCGAGACGATTCGCTT
GCGCCGCTATCGTCACCGCAATGCGCCACGTGACAATCAGCCAGCTTTGGTGTTTTACCACGGTGGCGGTTATGTTGGTG
GTTCGCTCAACTCTCACGACTTGGTCTGTCAGCATCTGGCCAATGGCGGCGAGTGTACGGTCATTGCTGTCGATTACCGT
CTGGCGCCTGAATACCCCTATCCTACGCCTGTTAACGATGGGTTAACTGCTTATCGCTATATTGCCAGTCATGCGGATAA
ATTCGGGATTGATGCCAATCGTTTGGCAGTCGGTGGTGACAGTGCAGGCGGTAACTTGGCGGCAGTGGTGGCACAGCAAA
CCAAAAATGACACGCATCCGCCCAAGCTGCAATTATTATGGGTGCCTTGGGTCGATATGAGCGGTGAGCATGAGTCCTAT
GAGCTGTTTGCCACAGGCTTTTTGTTAGAGCAAGCTCAGATGCGCTGGTACACCCATCACTATTTGGGTGATACAGATAA
GATTGATACCACAGACCCTATGGTCTCCCCTATATATGGTGACCTGCAAGGCGTGGCACCTGCGGTGGTCATGGTGGCAG
GCTTTGACCCACTGCGTGATGAGGGTGTTGAGTATGCCAATAAATTAACAGCAGCAGGTGTCGATACCACGCTTAAAGTG
TATGACAGCATGCCGCATCTGTTTATGCTTTATGCTGGTGAAATTGATGCCGCCAAAGTGGCTTTTGAGGATGCGGTACA
AGCACTAAAGCGGTTATAA

Upstream 100 bases:

>100_bases
GTGGTGACTTATAGAGCACTTTTGTTTACACCGCCCATCATCTGATATGGTATTAAAAAATATCCCGTTGCATCGTTTTA
AATTAAAAAAGAGGCGTTGA

Downstream 100 bases:

>100_bases
AGCACATAACACCTCTGCTTTTACCACTGGGTTTGTAATCGTTGGTTAATTTTCCGAGCGTTTATATTGCAAAACAAAGC
GTTATCCTCATCTATGAAGT

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTIINKSNLHQLSTKTRNALMKSVVRLPTAAKQQIAGEPIVIDGQTFDLSLQVMLQLFGPPPNHLPSVTEARATIEAQSP
VLSQTPLDDIIKDEFPLTVSDGETIRLRRYRHRNAPRDNQPALVFYHGGGYVGGSLNSHDLVCQHLANGGECTVIAVDYR
LAPEYPYPTPVNDGLTAYRYIASHADKFGIDANRLAVGGDSAGGNLAAVVAQQTKNDTHPPKLQLLWVPWVDMSGEHESY
ELFATGFLLEQAQMRWYTHHYLGDTDKIDTTDPMVSPIYGDLQGVAPAVVMVAGFDPLRDEGVEYANKLTAAGVDTTLKV
YDSMPHLFMLYAGEIDAAKVAFEDAVQALKRL

Sequences:

>Translated_352_residues
MTIINKSNLHQLSTKTRNALMKSVVRLPTAAKQQIAGEPIVIDGQTFDLSLQVMLQLFGPPPNHLPSVTEARATIEAQSP
VLSQTPLDDIIKDEFPLTVSDGETIRLRRYRHRNAPRDNQPALVFYHGGGYVGGSLNSHDLVCQHLANGGECTVIAVDYR
LAPEYPYPTPVNDGLTAYRYIASHADKFGIDANRLAVGGDSAGGNLAAVVAQQTKNDTHPPKLQLLWVPWVDMSGEHESY
ELFATGFLLEQAQMRWYTHHYLGDTDKIDTTDPMVSPIYGDLQGVAPAVVMVAGFDPLRDEGVEYANKLTAAGVDTTLKV
YDSMPHLFMLYAGEIDAAKVAFEDAVQALKRL
>Mature_351_residues
TIINKSNLHQLSTKTRNALMKSVVRLPTAAKQQIAGEPIVIDGQTFDLSLQVMLQLFGPPPNHLPSVTEARATIEAQSPV
LSQTPLDDIIKDEFPLTVSDGETIRLRRYRHRNAPRDNQPALVFYHGGGYVGGSLNSHDLVCQHLANGGECTVIAVDYRL
APEYPYPTPVNDGLTAYRYIASHADKFGIDANRLAVGGDSAGGNLAAVVAQQTKNDTHPPKLQLLWVPWVDMSGEHESYE
LFATGFLLEQAQMRWYTHHYLGDTDKIDTTDPMVSPIYGDLQGVAPAVVMVAGFDPLRDEGVEYANKLTAAGVDTTLKVY
DSMPHLFMLYAGEIDAAKVAFEDAVQALKRL

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=121, Percent_Identity=38.0165289256198, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI206597554, Length=156, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI68051721, Length=307, Percent_Identity=24.1042345276873, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI68299767, Length=125, Percent_Identity=34.4, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI21328446, Length=101, Percent_Identity=36.6336633663366, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI226423947, Length=312, Percent_Identity=23.3974358974359, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI61966717, Length=136, Percent_Identity=28.6764705882353, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI157041237, Length=89, Percent_Identity=35.9550561797753, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786682, Length=238, Percent_Identity=29.8319327731092, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17567059, Length=264, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI72001146, Length=408, Percent_Identity=24.5098039215686, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17540028, Length=170, Percent_Identity=30.5882352941176, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71996133, Length=141, Percent_Identity=32.6241134751773, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115533410, Length=108, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115533412, Length=108, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656084, Length=104, Percent_Identity=38.4615384615385, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24656076, Length=104, Percent_Identity=38.4615384615385, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130169, Length=104, Percent_Identity=38.4615384615385, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 38599; Mature: 38468

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIINKSNLHQLSTKTRNALMKSVVRLPTAAKQQIAGEPIVIDGQTFDLSLQVMLQLFGP
CEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCEECHHHHHHHHHHCC
PPNHLPSVTEARATIEAQSPVLSQTPLDDIIKDEFPLTVSDGETIRLRRYRHRNAPRDNQ
CCCCCCCHHHHHHEEECCCCCCCCCCHHHHHHCCCCEEECCCCEEEEEHHHHCCCCCCCC
PALVFYHGGGYVGGSLNSHDLVCQHLANGGECTVIAVDYRLAPEYPYPTPVNDGLTAYRY
CEEEEECCCEEECCCCCCHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHH
IASHADKFGIDANRLAVGGDSAGGNLAAVVAQQTKNDTHPPKLQLLWVPWVDMSGEHESY
HHHCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCE
ELFATGFLLEQAQMRWYTHHYLGDTDKIDTTDPMVSPIYGDLQGVAPAVVMVAGFDPLRD
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCHHH
EGVEYANKLTAAGVDTTLKVYDSMPHLFMLYAGEIDAAKVAFEDAVQALKRL
HHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIINKSNLHQLSTKTRNALMKSVVRLPTAAKQQIAGEPIVIDGQTFDLSLQVMLQLFGP
EECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCEECHHHHHHHHHHCC
PPNHLPSVTEARATIEAQSPVLSQTPLDDIIKDEFPLTVSDGETIRLRRYRHRNAPRDNQ
CCCCCCCHHHHHHEEECCCCCCCCCCHHHHHHCCCCEEECCCCEEEEEHHHHCCCCCCCC
PALVFYHGGGYVGGSLNSHDLVCQHLANGGECTVIAVDYRLAPEYPYPTPVNDGLTAYRY
CEEEEECCCEEECCCCCCHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHH
IASHADKFGIDANRLAVGGDSAGGNLAAVVAQQTKNDTHPPKLQLLWVPWVDMSGEHESY
HHHCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCE
ELFATGFLLEQAQMRWYTHHYLGDTDKIDTTDPMVSPIYGDLQGVAPAVVMVAGFDPLRD
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCHHH
EGVEYANKLTAAGVDTTLKVYDSMPHLFMLYAGEIDAAKVAFEDAVQALKRL
HHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]