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The map label for this gene is opuE [H]

Identifier: 148653736

GI number: 148653736

Start: 2406062

End: 2407558

Strand: Direct

Name: opuE [H]

Synonym: PsycPRwf_1939

Alternate gene names: 148653736

Gene position: 2406062-2407558 (Clockwise)

Preceding gene: 148653734

Following gene: 148653740

Centisome position: 80.77

GC content: 46.56

Gene sequence:

>1497_bases
ATGAATGGAATTGAACCTGGCGTGCTCATCTCGCTCGCCCTCTACTTTTTACTGATGATTGCCATCGGTATTTGGGCCTA
TTTTAAGGCCGAAAACGACTCAGAAGGCTATATGCTGGGCGGTCGTAACTTAAGCCCAGGGGTTGCCGCCTTATCTGCAG
GCGCCTCGGATATGTCAGGTTGGCTATTATTAGGCCTACCCGGCTACATGTACAGCTCAGGTGTGGTTAGTATCTGGATT
GCTTTAGGCTTAACCCTCGGCGCCTTTGCGAACTATCTCTTAGTGGCCCCAAGACTGCGTGTCTATACAGAAGTCGCTGA
CAACGCCATCACCCTGCCCGATTATTTCGCCAACCGTTTTGAAGACAAGTCTCACCTGCTTCGTGTCATCTCAGCCATCG
TTATTATTTTATTCTTTACCGTGTATACTGCAGCCAGCTTAGCCGGCGGTGGTAAATTATTCGACAGCGCCCTAGGCATG
TCTTATAGCACAGGCCTGTGGGTAACGGCAGGTGTGGTTGTGGCCTATACCTTATTCGGTGGCTTCTTAGCAGTTTCGAC
CACGGATTTTGTGCAAGGCGTCATTATGCTATTGGCGATGATTATTGTACCTGTCGTGGCCTTTACAGATTTAGGCGGTG
TGGGTGCCACAACCACAGCCATTCGCAATATTGACCCCCAAATGCTTAACATCTTTAGCGGCATGAGCTTTTTAGGCATT
TTGTCATTGATGGCATGGGGTTTAGGCTATTTTGGTCAGCCACACATTATCGTACGCTTCATGGCGATTCGTTCAGTAAA
AGACGTGCCAACTGCCCGTAGAATTGGTATGAGCTGGATGATTGTCAGCTTAATCGGGGCATTAATGACAGGCTTTGCTG
GTCGTGCTTATGTCCAAAAAACTGCCATGACCTTAGATGATCCAGAGACCATCTTCTTAGTATTCACTAACTTCTTATTC
CATCCTTTAGTCTCAGGCTTCTTGTTAGCAGCGATTTTAGCCGCCATTATGAGTACCATATCCTCACAGTTACTGGTAGT
GTCAAGCTCTCTAACCCGTGATGTGTATAAATTATTCTTTGATAGACAGGCCCCAGAAGCGCGTCAAGTATTGGTAGGTC
GTATCTCTGTTGTCGTGGTAGCTTTGGTATCTATTTTCTTAGCTTCCGACCCTGACAGCTCAGTATTATCGCTTGTGTCT
AACGCATGGGCAGGCTTTGGTGCTGCCTTTGGTCCGTTGGTTATTATTAGCTTAATGTGGAAACGTATGAACCGTAATGG
TGCGCTAGCAGGTATGATTGTCGGTGCCCTAACCGTGATTATTTGGGTCTATGCAGGCATACAAACTCCTGATGGCGTCG
CTTTAAATGACTGGTTATATGCCATTATCCCAGGCTTTATTTTAAGCTCTATTGCTATTGTGGTTGTCAGCTTGGCCACT
GCTGCACCAAGTGCCAAAATTCAAGCCAAATTTGAAGAGATGGAAACCAATCTATAA

Upstream 100 bases:

>100_bases
GGGCATTTGATGTATAGTGTGATGTGCATTTCACTATTTTATCAATTTCTCAGCCTGTTTTTTTCCCAGCCTACTTTTTG
AACCACCACCGGATTTTGTT

Downstream 100 bases:

>100_bases
CCATAGCCTCACTTCAAACCACACTTCATCAACACCAAAGACCTCGCATGATGCGAGGTTTTTTTGTCTAGAGATAAATG
TATTTTACCTGCCCGCTAGA

Product: sodium/proline symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MNGIEPGVLISLALYFLLMIAIGIWAYFKAENDSEGYMLGGRNLSPGVAALSAGASDMSGWLLLGLPGYMYSSGVVSIWI
ALGLTLGAFANYLLVAPRLRVYTEVADNAITLPDYFANRFEDKSHLLRVISAIVIILFFTVYTAASLAGGGKLFDSALGM
SYSTGLWVTAGVVVAYTLFGGFLAVSTTDFVQGVIMLLAMIIVPVVAFTDLGGVGATTTAIRNIDPQMLNIFSGMSFLGI
LSLMAWGLGYFGQPHIIVRFMAIRSVKDVPTARRIGMSWMIVSLIGALMTGFAGRAYVQKTAMTLDDPETIFLVFTNFLF
HPLVSGFLLAAILAAIMSTISSQLLVVSSSLTRDVYKLFFDRQAPEARQVLVGRISVVVVALVSIFLASDPDSSVLSLVS
NAWAGFGAAFGPLVIISLMWKRMNRNGALAGMIVGALTVIIWVYAGIQTPDGVALNDWLYAIIPGFILSSIAIVVVSLAT
AAPSAKIQAKFEEMETNL

Sequences:

>Translated_498_residues
MNGIEPGVLISLALYFLLMIAIGIWAYFKAENDSEGYMLGGRNLSPGVAALSAGASDMSGWLLLGLPGYMYSSGVVSIWI
ALGLTLGAFANYLLVAPRLRVYTEVADNAITLPDYFANRFEDKSHLLRVISAIVIILFFTVYTAASLAGGGKLFDSALGM
SYSTGLWVTAGVVVAYTLFGGFLAVSTTDFVQGVIMLLAMIIVPVVAFTDLGGVGATTTAIRNIDPQMLNIFSGMSFLGI
LSLMAWGLGYFGQPHIIVRFMAIRSVKDVPTARRIGMSWMIVSLIGALMTGFAGRAYVQKTAMTLDDPETIFLVFTNFLF
HPLVSGFLLAAILAAIMSTISSQLLVVSSSLTRDVYKLFFDRQAPEARQVLVGRISVVVVALVSIFLASDPDSSVLSLVS
NAWAGFGAAFGPLVIISLMWKRMNRNGALAGMIVGALTVIIWVYAGIQTPDGVALNDWLYAIIPGFILSSIAIVVVSLAT
AAPSAKIQAKFEEMETNL
>Mature_498_residues
MNGIEPGVLISLALYFLLMIAIGIWAYFKAENDSEGYMLGGRNLSPGVAALSAGASDMSGWLLLGLPGYMYSSGVVSIWI
ALGLTLGAFANYLLVAPRLRVYTEVADNAITLPDYFANRFEDKSHLLRVISAIVIILFFTVYTAASLAGGGKLFDSALGM
SYSTGLWVTAGVVVAYTLFGGFLAVSTTDFVQGVIMLLAMIIVPVVAFTDLGGVGATTTAIRNIDPQMLNIFSGMSFLGI
LSLMAWGLGYFGQPHIIVRFMAIRSVKDVPTARRIGMSWMIVSLIGALMTGFAGRAYVQKTAMTLDDPETIFLVFTNFLF
HPLVSGFLLAAILAAIMSTISSQLLVVSSSLTRDVYKLFFDRQAPEARQVLVGRISVVVVALVSIFLASDPDSSVLSLVS
NAWAGFGAAFGPLVIISLMWKRMNRNGALAGMIVGALTVIIWVYAGIQTPDGVALNDWLYAIIPGFILSSIAIVVVSLAT
AAPSAKIQAKFEEMETNL

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=491, Percent_Identity=54.5824847250509, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI14140236, Length=473, Percent_Identity=21.7758985200846, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI109659836, Length=494, Percent_Identity=24.0890688259109, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI109659839, Length=510, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI110835708, Length=548, Percent_Identity=22.2627737226277, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4507031, Length=466, Percent_Identity=22.9613733905579, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI11141885, Length=392, Percent_Identity=25.2551020408163, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI17941285, Length=472, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI206597483, Length=462, Percent_Identity=23.5930735930736, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787251, Length=500, Percent_Identity=51.8, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI87082237, Length=450, Percent_Identity=27.7777777777778, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790503, Length=453, Percent_Identity=23.1788079470199, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17539284, Length=419, Percent_Identity=22.673031026253, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24648033, Length=394, Percent_Identity=23.8578680203046, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356865, Length=394, Percent_Identity=23.8578680203046, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645928, Length=377, Percent_Identity=27.3209549071618, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221459584, Length=400, Percent_Identity=24.5, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362918, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24651739, Length=485, Percent_Identity=24.7422680412371, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53199; Mature: 53199

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGIEPGVLISLALYFLLMIAIGIWAYFKAENDSEGYMLGGRNLSPGVAALSAGASDMSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCCCCC
WLLLGLPGYMYSSGVVSIWIALGLTLGAFANYLLVAPRLRVYTEVADNAITLPDYFANRF
EEEECCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCHHHHHHC
EDKSHLLRVISAIVIILFFTVYTAASLAGGGKLFDSALGMSYSTGLWVTAGVVVAYTLFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GFLAVSTTDFVQGVIMLLAMIIVPVVAFTDLGGVGATTTAIRNIDPQMLNIFSGMSFLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
LSLMAWGLGYFGQPHIIVRFMAIRSVKDVPTARRIGMSWMIVSLIGALMTGFAGRAYVQK
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TAMTLDDPETIFLVFTNFLFHPLVSGFLLAAILAAIMSTISSQLLVVSSSLTRDVYKLFF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRQAPEARQVLVGRISVVVVALVSIFLASDPDSSVLSLVSNAWAGFGAAFGPLVIISLMW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KRMNRNGALAGMIVGALTVIIWVYAGIQTPDGVALNDWLYAIIPGFILSSIAIVVVSLAT
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAPSAKIQAKFEEMETNL
CCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNGIEPGVLISLALYFLLMIAIGIWAYFKAENDSEGYMLGGRNLSPGVAALSAGASDMSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCCCCC
WLLLGLPGYMYSSGVVSIWIALGLTLGAFANYLLVAPRLRVYTEVADNAITLPDYFANRF
EEEECCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCHHHHHHC
EDKSHLLRVISAIVIILFFTVYTAASLAGGGKLFDSALGMSYSTGLWVTAGVVVAYTLFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
GFLAVSTTDFVQGVIMLLAMIIVPVVAFTDLGGVGATTTAIRNIDPQMLNIFSGMSFLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
LSLMAWGLGYFGQPHIIVRFMAIRSVKDVPTARRIGMSWMIVSLIGALMTGFAGRAYVQK
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TAMTLDDPETIFLVFTNFLFHPLVSGFLLAAILAAIMSTISSQLLVVSSSLTRDVYKLFF
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRQAPEARQVLVGRISVVVVALVSIFLASDPDSSVLSLVSNAWAGFGAAFGPLVIISLMW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KRMNRNGALAGMIVGALTVIIWVYAGIQTPDGVALNDWLYAIIPGFILSSIAIVVVSLAT
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAPSAKIQAKFEEMETNL
CCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]