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The map label for this gene is fabR [H]

Identifier: 148653709

GI number: 148653709

Start: 2375362

End: 2376069

Strand: Direct

Name: fabR [H]

Synonym: PsycPRwf_1912

Alternate gene names: 148653709

Gene position: 2375362-2376069 (Clockwise)

Preceding gene: 148653708

Following gene: 148653713

Centisome position: 79.74

GC content: 45.06

Gene sequence:

>708_bases
ATGACCACCCCCAACACCCTTAATTTAAATACCCGCGAACAAAAAAAGATGCAGACCCGACAAGCATTTTTTAACGCGGT
GCTTGATTTGTGTATGATGGGTCAATCCTTTGCCTCCATTAGTTTGCGCCAAGTGACTCGTGAGGTGGGGGTTGTGCCTA
CTGCCTTTTATCGTCATTTTGATGATATGGAAAGCTTGGGCAGAAGCTTAGTAGAAGAAGAGCTTGGTGAAGCCTTATCT
ACCTTACGTAATGGTTTGCAAATGGGGCGCACGCGCAGCTTTGATCGTCAAATTGCCAATAGCATTCAACTATTTTTTGC
CTCAATTGATGAGCACCCTCGCTATTGGCAGTTTTTAGTCAGTGAGCGCTTTGGTGGCTCAGAGTCAGTGCGCAACGCCA
TTGCTGCCCAAATTAAGCTATTTGCTAAAATTATGGGCGAAGATTTAGGCATACAGCCGGCGTTTAGTCATATCAACTCC
GAAGACAGACGCTTGTTGGCTGAGGCTGGGCTCAATTTATTTTTGACGTGGATTATTGATTGGCTGGATCTGACCTATTC
ACAAGCACACGATGAAGAAAGCGACTTAACAGGCGTCAGTGCTAAAAAAGATTTGATGCTTAGACAATGCACACGCCAAG
CACAAATGCTGTTCTATGGTGCAGAGAATTGGCGCTCTAATGAGGCCACCTTGTTGCCTAATGATTAA

Upstream 100 bases:

>100_bases
GCATGATTTTGTTGTTGGCTTTAAGGCGTACCTATTCGTTCAACTAGAGGCAGCTTGCCTCGCCTAACCTTTTGTTTATT
AGCCACGAGAGTGTTTTATC

Downstream 100 bases:

>100_bases
TACCTAATCGGTAAGCGATAATATCTGATAGGTTAGGACATCTGCGATCATCTACCCTGCAAGAAAAAGCCCTTTAATCG
TTAAAGGGCTTTTTTACCGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTTPNTLNLNTREQKKMQTRQAFFNAVLDLCMMGQSFASISLRQVTREVGVVPTAFYRHFDDMESLGRSLVEEELGEALS
TLRNGLQMGRTRSFDRQIANSIQLFFASIDEHPRYWQFLVSERFGGSESVRNAIAAQIKLFAKIMGEDLGIQPAFSHINS
EDRRLLAEAGLNLFLTWIIDWLDLTYSQAHDEESDLTGVSAKKDLMLRQCTRQAQMLFYGAENWRSNEATLLPND

Sequences:

>Translated_235_residues
MTTPNTLNLNTREQKKMQTRQAFFNAVLDLCMMGQSFASISLRQVTREVGVVPTAFYRHFDDMESLGRSLVEEELGEALS
TLRNGLQMGRTRSFDRQIANSIQLFFASIDEHPRYWQFLVSERFGGSESVRNAIAAQIKLFAKIMGEDLGIQPAFSHINS
EDRRLLAEAGLNLFLTWIIDWLDLTYSQAHDEESDLTGVSAKKDLMLRQCTRQAQMLFYGAENWRSNEATLLPND
>Mature_234_residues
TTPNTLNLNTREQKKMQTRQAFFNAVLDLCMMGQSFASISLRQVTREVGVVPTAFYRHFDDMESLGRSLVEEELGEALST
LRNGLQMGRTRSFDRQIANSIQLFFASIDEHPRYWQFLVSERFGGSESVRNAIAAQIKLFAKIMGEDLGIQPAFSHINSE
DRRLLAEAGLNLFLTWIIDWLDLTYSQAHDEESDLTGVSAKKDLMLRQCTRQAQMLFYGAENWRSNEATLLPND

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=232, Percent_Identity=29.3103448275862, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26841; Mature: 26710

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPNTLNLNTREQKKMQTRQAFFNAVLDLCMMGQSFASISLRQVTREVGVVPTAFYRHF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHH
DDMESLGRSLVEEELGEALSTLRNGLQMGRTRSFDRQIANSIQLFFASIDEHPRYWQFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SERFGGSESVRNAIAAQIKLFAKIMGEDLGIQPAFSHINSEDRRLLAEAGLNLFLTWIID
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
WLDLTYSQAHDEESDLTGVSAKKDLMLRQCTRQAQMLFYGAENWRSNEATLLPND
HHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPNTLNLNTREQKKMQTRQAFFNAVLDLCMMGQSFASISLRQVTREVGVVPTAFYRHF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHH
DDMESLGRSLVEEELGEALSTLRNGLQMGRTRSFDRQIANSIQLFFASIDEHPRYWQFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SERFGGSESVRNAIAAQIKLFAKIMGEDLGIQPAFSHINSEDRRLLAEAGLNLFLTWIID
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
WLDLTYSQAHDEESDLTGVSAKKDLMLRQCTRQAQMLFYGAENWRSNEATLLPND
HHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA