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The map label for this gene is pox5 [H]

Identifier: 148653393

GI number: 148653393

Start: 1963927

End: 1965738

Strand: Direct

Name: pox5 [H]

Synonym: PsycPRwf_1595

Alternate gene names: 148653393

Gene position: 1963927-1965738 (Clockwise)

Preceding gene: 148653390

Following gene: 148653403

Centisome position: 65.93

GC content: 47.74

Gene sequence:

>1812_bases
ATGAATAAAATACTAAGTGCAGATGCCATGATGAAGGTATTGAACGATTGGGGAGTTAAGCGGATATATGGCTTACCTGG
CGGCTCTCTTGACTCAACCATGAATGCCATTTATAACTGGCGAGATAAGATTAAATATATCGGTGTTCGTCATGAAGAGG
TCGGTGGTCTGGCCGCGGTGGCTGAGGCAAAGTGGACCGGTAAAATTGCGGTTATGCTAGGCTCTGCAGGCCCAGGTGCT
GCCCATTTATTAAATCCGCTGCATGATGCCGCTTTGGATCATATTCCAGTATTGGCCATTGTCGGTCAGGTACCAAGTGA
TAAGATGAATACCGACTACTTCCAAGAAATGCCTGAAAACCCAATGTTTGCAAGTTCTGCTGTCTATAACCGCACGGTAA
TGACACCCGAACAGCTACCAGAAATCATCGACACTGCCATTCGCAAAGCTTATGAGCTCAGAGGTCCGGCAGTGATTGTT
ATTCCTAAAGATTTTGGCTGGGTGGAGATTGAGGATAATTACATCTCTTCTGCCCAAAAATACAGCACGCCGCAGTGGCA
ACAGCCTGCCAATGAGGAGGATGTCGAAAAGGTATTGGATTTACTTAAGCAGTCAAGTCGCCCTATTATCTATTTTGGCC
GCGGCGCGCAGGGTGCCGCCGATGAGCTGCGTGAGCTTGCTGCTTTATTGAAACTGCCGATGGTATCTAGTTATTTAGCC
AAAGGCATCTTAGAGGGTGACGAAGAGTTTTATATGCTCTCTACTGGACGCGTGGCGACTAAGCCTGGCGTCGATGTCGC
CCGTGCTGCAGACTTTGTGCTCTTTACTGGTACCAATTTTGAATTCCCCATGTTCTCAGAAGAGGCAACCTTTGTGGATG
TCAACCTCAACCCTTCTGTCATTGGCGCCAGACACCAGACTAAGCTTGGTATCTTAGCCGACGTCCCGACATTTTTGCGT
CAATTGCTTAACGCCGCAAAAAAACGTTATGGCGAAGACGGCGCAAACTATGCGTCTGCCCGAGCCCGTCAGCAAGATAG
TGATTATCAGGCTTGGTATACCGCGGCAGTAGAAGACAAAAAACAATGGGATGCATGGCTTGCAAAACGTGCTGAGCGCA
ACACCAATCCAGTTGGCTTTGAAAGCGTATACAAATTCATTAACAAAATGGCAGCGAAAGATGCACTGTTTGGCGTGGAT
GTGGGTAATGTTAATATTGCCGTAGCTCGTCTACTCAGCTTAGGTGGCGGACGTCGTCAGGTGACTTCCCCACTTTATGC
AACGATGGGCTTTGGTATGCCAGCCGCCATTGCCGCAGCGCTAGAGTACCCTGATCGTGAGGTCTGGAGCTTATCAGGAG
ATGGCGGCTTGGCGATGGTGGTACCTGATCTAATCACCCAAGCAGAGCATGAGCTACCCATTATGAACTTGGTATTTACC
AATGAGTCTTTAGGATATATCGAGGCCGAACAAGATGATACCCATCAGCCGCATTCGGGTATTAAACTACAAAATGTTGA
CTTTGCAAAAGTCGCAGAAGGCTTCCAAGTGACTGGCTTTACCGTACACAAAGCTGAAGAGCTTGAATCTGTGTTACAAC
AAGCTCAGCAAGTCACCCGCAGCGGCAAACCGGTACTGGTAGATATAAAAATCACCAATGAGCGATTATTGCCTGTCGAA
CAGTTCCCGCACCGCCGCTCTGGTGAGCCAGATGTGATTGCTGATTTTGATAAATTTGTTGAGCATTTTGAAGCAGAAGC
ACTTGAGCCCTTTGGTGAGATATTAGATCGTCATGGCGTAACAAGCTTTTAG

Upstream 100 bases:

>100_bases
CTTGGTTACAATTTTTTAAAGTATGTCTATATGGTTAGTAACAGTGAGATGCTACTTTTATCCCTAAGATAAGCAAAGAC
CATAAAATAAGGAGATAATC

Downstream 100 bases:

>100_bases
AAGCACCGCTCATCACATCTTTAAAATCACAGCTGAAGCTGAAAATGCCCTACTCAACATCAGCTGCTATAGAAGATACA
ACCTGTAAAACATAGAGCAA

Product: pyruvate oxidase

Products: NA

Alternate protein names: Pyruvic oxidase; POX [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNKILSADAMMKVLNDWGVKRIYGLPGGSLDSTMNAIYNWRDKIKYIGVRHEEVGGLAAVAEAKWTGKIAVMLGSAGPGA
AHLLNPLHDAALDHIPVLAIVGQVPSDKMNTDYFQEMPENPMFASSAVYNRTVMTPEQLPEIIDTAIRKAYELRGPAVIV
IPKDFGWVEIEDNYISSAQKYSTPQWQQPANEEDVEKVLDLLKQSSRPIIYFGRGAQGAADELRELAALLKLPMVSSYLA
KGILEGDEEFYMLSTGRVATKPGVDVARAADFVLFTGTNFEFPMFSEEATFVDVNLNPSVIGARHQTKLGILADVPTFLR
QLLNAAKKRYGEDGANYASARARQQDSDYQAWYTAAVEDKKQWDAWLAKRAERNTNPVGFESVYKFINKMAAKDALFGVD
VGNVNIAVARLLSLGGGRRQVTSPLYATMGFGMPAAIAAALEYPDREVWSLSGDGGLAMVVPDLITQAEHELPIMNLVFT
NESLGYIEAEQDDTHQPHSGIKLQNVDFAKVAEGFQVTGFTVHKAEELESVLQQAQQVTRSGKPVLVDIKITNERLLPVE
QFPHRRSGEPDVIADFDKFVEHFEAEALEPFGEILDRHGVTSF

Sequences:

>Translated_603_residues
MNKILSADAMMKVLNDWGVKRIYGLPGGSLDSTMNAIYNWRDKIKYIGVRHEEVGGLAAVAEAKWTGKIAVMLGSAGPGA
AHLLNPLHDAALDHIPVLAIVGQVPSDKMNTDYFQEMPENPMFASSAVYNRTVMTPEQLPEIIDTAIRKAYELRGPAVIV
IPKDFGWVEIEDNYISSAQKYSTPQWQQPANEEDVEKVLDLLKQSSRPIIYFGRGAQGAADELRELAALLKLPMVSSYLA
KGILEGDEEFYMLSTGRVATKPGVDVARAADFVLFTGTNFEFPMFSEEATFVDVNLNPSVIGARHQTKLGILADVPTFLR
QLLNAAKKRYGEDGANYASARARQQDSDYQAWYTAAVEDKKQWDAWLAKRAERNTNPVGFESVYKFINKMAAKDALFGVD
VGNVNIAVARLLSLGGGRRQVTSPLYATMGFGMPAAIAAALEYPDREVWSLSGDGGLAMVVPDLITQAEHELPIMNLVFT
NESLGYIEAEQDDTHQPHSGIKLQNVDFAKVAEGFQVTGFTVHKAEELESVLQQAQQVTRSGKPVLVDIKITNERLLPVE
QFPHRRSGEPDVIADFDKFVEHFEAEALEPFGEILDRHGVTSF
>Mature_603_residues
MNKILSADAMMKVLNDWGVKRIYGLPGGSLDSTMNAIYNWRDKIKYIGVRHEEVGGLAAVAEAKWTGKIAVMLGSAGPGA
AHLLNPLHDAALDHIPVLAIVGQVPSDKMNTDYFQEMPENPMFASSAVYNRTVMTPEQLPEIIDTAIRKAYELRGPAVIV
IPKDFGWVEIEDNYISSAQKYSTPQWQQPANEEDVEKVLDLLKQSSRPIIYFGRGAQGAADELRELAALLKLPMVSSYLA
KGILEGDEEFYMLSTGRVATKPGVDVARAADFVLFTGTNFEFPMFSEEATFVDVNLNPSVIGARHQTKLGILADVPTFLR
QLLNAAKKRYGEDGANYASARARQQDSDYQAWYTAAVEDKKQWDAWLAKRAERNTNPVGFESVYKFINKMAAKDALFGVD
VGNVNIAVARLLSLGGGRRQVTSPLYATMGFGMPAAIAAALEYPDREVWSLSGDGGLAMVVPDLITQAEHELPIMNLVFT
NESLGYIEAEQDDTHQPHSGIKLQNVDFAKVAEGFQVTGFTVHKAEELESVLQQAQQVTRSGKPVLVDIKITNERLLPVE
QFPHRRSGEPDVIADFDKFVEHFEAEALEPFGEILDRHGVTSF

Specific function: Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=579, Percent_Identity=23.8341968911917, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI21361361, Length=592, Percent_Identity=23.3108108108108, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787096, Length=551, Percent_Identity=32.6678765880218, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1790104, Length=570, Percent_Identity=27.8947368421053, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87081685, Length=579, Percent_Identity=25.0431778929188, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786717, Length=582, Percent_Identity=25.4295532646048, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788716, Length=559, Percent_Identity=21.2880143112701, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17542570, Length=595, Percent_Identity=23.6974789915966, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17531299, Length=537, Percent_Identity=22.1601489757914, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531301, Length=537, Percent_Identity=22.1601489757914, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323755, Length=605, Percent_Identity=24.6280991735537, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320816, Length=577, Percent_Identity=23.050259965338, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922626, Length=580, Percent_Identity=24.1379310344828, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014092
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.3.3 [H]

Molecular weight: Translated: 66528; Mature: 66528

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILSADAMMKVLNDWGVKRIYGLPGGSLDSTMNAIYNWRDKIKYIGVRHEEVGGLAAV
CCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHEECCCHHHHCCCHHH
AEAKWTGKIAVMLGSAGPGAAHLLNPLHDAALDHIPVLAIVGQVPSDKMNTDYFQEMPEN
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHCCCC
PMFASSAVYNRTVMTPEQLPEIIDTAIRKAYELRGPAVIVIPKDFGWVEIEDNYISSAQK
CCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHH
YSTPQWQQPANEEDVEKVLDLLKQSSRPIIYFGRGAQGAADELRELAALLKLPMVSSYLA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KGILEGDEEFYMLSTGRVATKPGVDVARAADFVLFTGTNFEFPMFSEEATFVDVNLNPSV
HHHHCCCCCEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCCE
IGARHQTKLGILADVPTFLRQLLNAAKKRYGEDGANYASARARQQDSDYQAWYTAAVEDK
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHEEEHHHHHH
KQWDAWLAKRAERNTNPVGFESVYKFINKMAAKDALFGVDVGNVNIAVARLLSLGGGRRQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCHH
VTSPLYATMGFGMPAAIAAALEYPDREVWSLSGDGGLAMVVPDLITQAEHELPIMNLVFT
HCCHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEHHHHHHHHHCCCCEEEEEEE
NESLGYIEAEQDDTHQPHSGIKLQNVDFAKVAEGFQVTGFTVHKAEELESVLQQAQQVTR
CCCCCEEECCCCCCCCCCCCCEECCCCHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHH
SGKPVLVDIKITNERLLPVEQFPHRRSGEPDVIADFDKFVEHFEAEALEPFGEILDRHGV
CCCCEEEEEEECCCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
TSF
CCC
>Mature Secondary Structure
MNKILSADAMMKVLNDWGVKRIYGLPGGSLDSTMNAIYNWRDKIKYIGVRHEEVGGLAAV
CCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHEECCCHHHHCCCHHH
AEAKWTGKIAVMLGSAGPGAAHLLNPLHDAALDHIPVLAIVGQVPSDKMNTDYFQEMPEN
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHCCCC
PMFASSAVYNRTVMTPEQLPEIIDTAIRKAYELRGPAVIVIPKDFGWVEIEDNYISSAQK
CCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHH
YSTPQWQQPANEEDVEKVLDLLKQSSRPIIYFGRGAQGAADELRELAALLKLPMVSSYLA
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KGILEGDEEFYMLSTGRVATKPGVDVARAADFVLFTGTNFEFPMFSEEATFVDVNLNPSV
HHHHCCCCCEEEEECCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCCEEEEECCCCCE
IGARHQTKLGILADVPTFLRQLLNAAKKRYGEDGANYASARARQQDSDYQAWYTAAVEDK
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHEEEHHHHHH
KQWDAWLAKRAERNTNPVGFESVYKFINKMAAKDALFGVDVGNVNIAVARLLSLGGGRRQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCHH
VTSPLYATMGFGMPAAIAAALEYPDREVWSLSGDGGLAMVVPDLITQAEHELPIMNLVFT
HCCHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCEEEEHHHHHHHHHCCCCEEEEEEE
NESLGYIEAEQDDTHQPHSGIKLQNVDFAKVAEGFQVTGFTVHKAEELESVLQQAQQVTR
CCCCCEEECCCCCCCCCCCCCEECCCCHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHHH
SGKPVLVDIKITNERLLPVEQFPHRRSGEPDVIADFDKFVEHFEAEALEPFGEILDRHGV
CCCCEEEEEEECCCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
TSF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566; 8145244; 8438155 [H]