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The map label for this gene is nrdA [H]

Identifier: 148653375

GI number: 148653375

Start: 1938073

End: 1940349

Strand: Direct

Name: nrdA [H]

Synonym: PsycPRwf_1577

Alternate gene names: 148653375

Gene position: 1938073-1940349 (Clockwise)

Preceding gene: 148653374

Following gene: 148653376

Centisome position: 65.06

GC content: 46.55

Gene sequence:

>2277_bases
ATGACACATATGGATAATATTAAAGTAATGAAACGAGACGGCCGTCTAGAGCCCATCGATTTAGATAAAATCCATAAGGT
CATTACTTGGGCAGCCGAAGGATTAGACAATGTTTCTGTATCTCAGGTTGAGTTAAAGTCGCACATTCAGTTTTATGATG
GCATCAAAACCCGTGACATTCACGAGACCATCATTAAGGCTGCTGCTGACCTAATCTCTGAGGATACGCCAGATTATCAA
TATCTTGCGGCACGTTTGGCAATCTTCCACTTGCGTAAAATTGCCTACAATCAATTTGAGCCACCTCACCTATTTGACCA
TGTAACCAAATTAACCGAGGCGGGTAAATACGATCAGCACATTTTACAAGACTACTCACGTGAAGAGTTTGATGAGTTAA
ATGACTACATCGACCACTGGCGCGATATGAATCTTGCTTATGCCGCTGCCGAACAAATGGCTGGTAAATACTTAGTACAA
GACCGTGTGACCAAAACCGTTTACGAAAGTCCGCAGTTCTTATATGTACTGGTGGGCATGTGTCTGTTCGCCTCATACGA
TAAGTCTGAGCGCATGCACTATGTGAAGCGTTTTTATGATGCCGCCTCTACGTTCAAAATCTCATTACCCACCCCCATTA
TGTCCGGTGTGCGCACCCCTTCACGTCAATTTAGCTCGTGCGTACTGATTGAATGTGGTGATAGCTTAGACTCAATCAAC
GCCACAACCAGCGCCATTGTACGCTATGTATCGCAGCGTGCTGGTATTGGTATCAATGCCGGTAACATCCGTGCGCTAGG
CAGCCCTATCCGAGGCGGTGAAGCTCAGCACACCGGCTGTATCCCTTTTTATAAGCTGTTCCAAACCGCAGTTAAATGCT
GCTCGCAAGGTGGCGTACGTGGCGGCGCGGCAACCTTATTCTACCCACTGTGGCACTTAGAAGTAGAGTCGCTATTGGTT
CTAAAAAATAACCGCGGCGTAGAAGACAACCGTGTGCGCCATATGGACTATGGCGTACAAATTAACCGCCCCTTATATAC
CCGTTTGATTAAAGGTGAAGACATCGCTTTATTCTCACCTTCAGATGTGCCTGGTCTATATGAAGCCTTCTTCGCTGACC
AAGACAAGTTTGAAGCGCTATACACCAAGTACGAAAAAGACGACAACATCCGCAAACGTCATGTGCCTGCAGCCGATCTA
TTTAGCTTATTGATGCAAGAGCGTGCCAGTACTGGTCGTATCTACATCCAAAACGTGGACCACTGCAACACGCACAGCCC
ATTTGACCCAACTGTCGCCCCTATCCGTCAGTCAAACCTATGTATGGAAATTGCGCTACCAACTAAGCCGCTGGATAATA
TTAATGACGAAGAAGGCGAAATTGCACTGTGCACCCTATCTGCGGTGAACCTTGGCGAAGTCGATAGCTTAGAGGATATC
GAAGAGCCTGCAGAATTAATCGTGCGCGCCTTAGATGCGCTACTTGATTACCAAGATTACCCAGTAAAAGCCGCTGAAAA
TGGCAGCATGAATCGCCGTACGCTGGGTGTGGGTGTGATTAACTATGCTTATTACTTGGCTAAAAATGGTACCCGCTACT
CGGACGGCTCAGCGCTTGGTCTGACGCACCAGACTTTTGAGGCATTGCAGTACTATTTACTAAAAGCCTCGAACAAACTG
GCCAAAGAAAAAGGCGCTTGCCCCGCCTTTAATGAGACCACTTACTCACAAGGTATTTTGCCGATTGATACTTACAAAGC
GGACTTAGATAAGGTGTGCAATGAGCCATTGCGCCTTGATTGGGAAGCGTTACGTCAGGAGATTAAAACCCATGGCCTTC
GCAACTCTACTTTGTCAGCCTTGATGCCTTCTGAGACCTCAAGCCAGATTGCTAACGCCACCAACGGTATTGAGCCACCT
CGTGGTCTGGTATCAGTAAAAGCGTCAAAAGATGGTATCTTAAAGCAAGTGGTGCCCGATATCTTAAACTTAAAAGGCAA
CTACGAGCTATTGTGGCAAATGCCAAATAATGATGGCTATCTAAAGCTGGTGGCCGTGATGCAAAAGTTCATTGACCAAA
GCATCTCCGCCAACACCAACTACGATCCAACCCGCTTCGAGGGCAATCGTGTACCTATGAAGGTATTGCTAAAAGACTTG
CTAACTGCTTATAAACTGGGCGTTAAGACACTTTACTATCACAACACTCGTGATGGTGCTAATGATGCTCAAGCCGATAT
CGATGACGGCTGTGCCAGCGGTGCTTGTAAGCTGTAA

Upstream 100 bases:

>100_bases
TGTGTTTAATATTTTAAGACACACACTATATATTGGGGTATTATTTTTCTGATTGTCAGGTTTTTGACCGGCAATCTGGT
GACAACGAGCGGAGAGAGCA

Downstream 100 bases:

>100_bases
TGCTATAGAATCAGTGTCGCATAAAATGGTTTATTGTATTGAATGCCCCCTTAAATTAAGGGGGTTATTTCGGATATAAA
AACACCATGACCCATTAAGT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Protein B1; Ribonucleoside-diphosphate reductase 1 R1 subunit; Ribonucleotide reductase 1 [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MTHMDNIKVMKRDGRLEPIDLDKIHKVITWAAEGLDNVSVSQVELKSHIQFYDGIKTRDIHETIIKAAADLISEDTPDYQ
YLAARLAIFHLRKIAYNQFEPPHLFDHVTKLTEAGKYDQHILQDYSREEFDELNDYIDHWRDMNLAYAAAEQMAGKYLVQ
DRVTKTVYESPQFLYVLVGMCLFASYDKSERMHYVKRFYDAASTFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
ATTSAIVRYVSQRAGIGINAGNIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLV
LKNNRGVEDNRVRHMDYGVQINRPLYTRLIKGEDIALFSPSDVPGLYEAFFADQDKFEALYTKYEKDDNIRKRHVPAADL
FSLLMQERASTGRIYIQNVDHCNTHSPFDPTVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGEVDSLEDI
EEPAELIVRALDALLDYQDYPVKAAENGSMNRRTLGVGVINYAYYLAKNGTRYSDGSALGLTHQTFEALQYYLLKASNKL
AKEKGACPAFNETTYSQGILPIDTYKADLDKVCNEPLRLDWEALRQEIKTHGLRNSTLSALMPSETSSQIANATNGIEPP
RGLVSVKASKDGILKQVVPDILNLKGNYELLWQMPNNDGYLKLVAVMQKFIDQSISANTNYDPTRFEGNRVPMKVLLKDL
LTAYKLGVKTLYYHNTRDGANDAQADIDDGCASGACKL

Sequences:

>Translated_758_residues
MTHMDNIKVMKRDGRLEPIDLDKIHKVITWAAEGLDNVSVSQVELKSHIQFYDGIKTRDIHETIIKAAADLISEDTPDYQ
YLAARLAIFHLRKIAYNQFEPPHLFDHVTKLTEAGKYDQHILQDYSREEFDELNDYIDHWRDMNLAYAAAEQMAGKYLVQ
DRVTKTVYESPQFLYVLVGMCLFASYDKSERMHYVKRFYDAASTFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
ATTSAIVRYVSQRAGIGINAGNIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLV
LKNNRGVEDNRVRHMDYGVQINRPLYTRLIKGEDIALFSPSDVPGLYEAFFADQDKFEALYTKYEKDDNIRKRHVPAADL
FSLLMQERASTGRIYIQNVDHCNTHSPFDPTVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGEVDSLEDI
EEPAELIVRALDALLDYQDYPVKAAENGSMNRRTLGVGVINYAYYLAKNGTRYSDGSALGLTHQTFEALQYYLLKASNKL
AKEKGACPAFNETTYSQGILPIDTYKADLDKVCNEPLRLDWEALRQEIKTHGLRNSTLSALMPSETSSQIANATNGIEPP
RGLVSVKASKDGILKQVVPDILNLKGNYELLWQMPNNDGYLKLVAVMQKFIDQSISANTNYDPTRFEGNRVPMKVLLKDL
LTAYKLGVKTLYYHNTRDGANDAQADIDDGCASGACKL
>Mature_757_residues
THMDNIKVMKRDGRLEPIDLDKIHKVITWAAEGLDNVSVSQVELKSHIQFYDGIKTRDIHETIIKAAADLISEDTPDYQY
LAARLAIFHLRKIAYNQFEPPHLFDHVTKLTEAGKYDQHILQDYSREEFDELNDYIDHWRDMNLAYAAAEQMAGKYLVQD
RVTKTVYESPQFLYVLVGMCLFASYDKSERMHYVKRFYDAASTFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSINA
TTSAIVRYVSQRAGIGINAGNIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLVL
KNNRGVEDNRVRHMDYGVQINRPLYTRLIKGEDIALFSPSDVPGLYEAFFADQDKFEALYTKYEKDDNIRKRHVPAADLF
SLLMQERASTGRIYIQNVDHCNTHSPFDPTVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGEVDSLEDIE
EPAELIVRALDALLDYQDYPVKAAENGSMNRRTLGVGVINYAYYLAKNGTRYSDGSALGLTHQTFEALQYYLLKASNKLA
KEKGACPAFNETTYSQGILPIDTYKADLDKVCNEPLRLDWEALRQEIKTHGLRNSTLSALMPSETSSQIANATNGIEPPR
GLVSVKASKDGILKQVVPDILNLKGNYELLWQMPNNDGYLKLVAVMQKFIDQSISANTNYDPTRFEGNRVPMKVLLKDLL
TAYKLGVKTLYYHNTRDGANDAQADIDDGCASGACKL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=791, Percent_Identity=27.6864728192162, Blast_Score=238, Evalue=2e-62,
Organism=Escherichia coli, GI2367133, Length=758, Percent_Identity=78.2321899736148, Blast_Score=1261, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=572, Percent_Identity=26.5734265734266, Blast_Score=166, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17555242, Length=804, Percent_Identity=27.1144278606965, Blast_Score=240, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322123, Length=802, Percent_Identity=28.6783042394015, Blast_Score=249, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6320914, Length=804, Percent_Identity=28.2338308457711, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17352481, Length=794, Percent_Identity=27.0780856423174, Blast_Score=239, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85074; Mature: 84943

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHMDNIKVMKRDGRLEPIDLDKIHKVITWAAEGLDNVSVSQVELKSHIQFYDGIKTRDI
CCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHH
HETIIKAAADLISEDTPDYQYLAARLAIFHLRKIAYNQFEPPHLFDHVTKLTEAGKYDQH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHH
ILQDYSREEFDELNDYIDHWRDMNLAYAAAEQMAGKYLVQDRVTKTVYESPQFLYVLVGM
HHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CLFASYDKSERMHYVKRFYDAASTFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
HHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHCH
ATTSAIVRYVSQRAGIGINAGNIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHLEVESLLVLKNNRGVEDNRVRHMDYGVQINRPLYTRLIKGEDIALFSP
CCCHHHHHHHHHHCEEEEEEEECCCCCCCCCEEEEECCEEECCHHHHHHCCCCCEEEECC
SDVPGLYEAFFADQDKFEALYTKYEKDDNIRKRHVPAADLFSLLMQERASTGRIYIQNVD
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDPTVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGEVDSLEDI
CCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EEPAELIVRALDALLDYQDYPVKAAENGSMNRRTLGVGVINYAYYLAKNGTRYSDGSALG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCEEC
LTHQTFEALQYYLLKASNKLAKEKGACPAFNETTYSQGILPIDTYKADLDKVCNEPLRLD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
WEALRQEIKTHGLRNSTLSALMPSETSSQIANATNGIEPPRGLVSVKASKDGILKQVVPD
HHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
ILNLKGNYELLWQMPNNDGYLKLVAVMQKFIDQSISANTNYDPTRFEGNRVPMKVLLKDL
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LTAYKLGVKTLYYHNTRDGANDAQADIDDGCASGACKL
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THMDNIKVMKRDGRLEPIDLDKIHKVITWAAEGLDNVSVSQVELKSHIQFYDGIKTRDI
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHH
HETIIKAAADLISEDTPDYQYLAARLAIFHLRKIAYNQFEPPHLFDHVTKLTEAGKYDQH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHH
ILQDYSREEFDELNDYIDHWRDMNLAYAAAEQMAGKYLVQDRVTKTVYESPQFLYVLVGM
HHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CLFASYDKSERMHYVKRFYDAASTFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
HHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHCH
ATTSAIVRYVSQRAGIGINAGNIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHLEVESLLVLKNNRGVEDNRVRHMDYGVQINRPLYTRLIKGEDIALFSP
CCCHHHHHHHHHHCEEEEEEEECCCCCCCCCEEEEECCEEECCHHHHHHCCCCCEEEECC
SDVPGLYEAFFADQDKFEALYTKYEKDDNIRKRHVPAADLFSLLMQERASTGRIYIQNVD
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDPTVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGEVDSLEDI
CCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EEPAELIVRALDALLDYQDYPVKAAENGSMNRRTLGVGVINYAYYLAKNGTRYSDGSALG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCEEC
LTHQTFEALQYYLLKASNKLAKEKGACPAFNETTYSQGILPIDTYKADLDKVCNEPLRLD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
WEALRQEIKTHGLRNSTLSALMPSETSSQIANATNGIEPPRGLVSVKASKDGILKQVVPD
HHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
ILNLKGNYELLWQMPNNDGYLKLVAVMQKFIDQSISANTNYDPTRFEGNRVPMKVLLKDL
HHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
LTAYKLGVKTLYYHNTRDGANDAQADIDDGCASGACKL
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6087316; 3287341; 9205837; 9278503; 3894026; 2663852; 8702814; 8052308; 9309223; 10493864 [H]